Institute of Life Science 1 internal Atrium view up

Dr Eylan Yutuc

Lecturer - MSc Programmes Manager

Biomedical Sciences

+44 (0) 1792 602851

eylan.yutuc@swansea.ac.uk

Research Office - 038
Ground Floor
Institute of Life Science 1
Singleton Campus

Available For Postgraduate Supervision

Research Links

https://orcid.org/0000-0001-9971-1950

ResearchGate

Google Scholar

ResearcherID

Scopus

About

Dr Eylan Yutuc is a Lecturer in Biomedical Sciences at Swansea University Medical School, where his research spans lipid biochemistry, liquid-chromatography mass spectrometry, MALDI MS, neuroscience, and immunology. He completed his BSc in Biomedical Science at Brunel University London and his PhD in Medical and Health Care Studies at Swansea University, where he trained in sterol analysis and mass spectrometry-based lipid research in the context of immune function.

His work now focuses on how lipid metabolism shapes cell function in the brain and immune system, with particular interest in the microbiome-gut-brain axis, neuronal differentiation, and neurodegenerative disease. Using mass spectrometry and related analytical approaches, he studies lipid remodelling in human and model systems to support biomarker discovery, disease modelling, and deeper mechanistic understanding. His current projects investigate lipidomic changes during dopaminergic neuron development and the effects of gut-derived metabolites on neuronal biology in models relevant to Parkinson’s disease.

He is a Member of the Royal Society of Chemistry and the Royal Society of Biology, and he contributes to undergraduate and postgraduate teaching, and student supervision. More broadly, his research aims to connect analytical chemistry with translational neuroscience, helping to identify lipid-based mechanisms and candidate biomarkers that may ultimately improve understanding of neurodegenerative disease.

Areas Of Expertise

Lipid Biochemistry
Liquid-Chromatography Mass Spectrometry
MALDI MS
Neuroscience
Immunology

Career Highlights

Teaching Interests

Eylan teaches biomedical sciences in a way that helps students connect what they learn in lectures with the kinds of questions researchers are asking now, especially in lipid biochemistry, mass spectrometry, and neuroscience. His background in sterol analysis and lipidomics means he can bring real examples from research into the classroom, showing how analytical methods are used to study cell biology, biomarker discovery, and disease. He is especially interested in helping students understand how laboratory techniques fit into bigger biomedical problems, including the microbiome-gut-brain axis and neurodegenerative diseases. In teaching, he aims to make complex material feel accessible, relevant, and forward looking, so that students can see how scientific skills transfer into research, healthcare, and industry. He is well placed to support students who want a strong grounding in practical analytical science as well as those thinking about postgraduate study or research careers.

Research

Publications

Research Highlights

Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., & Griffiths, W. (2020). Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism. Proceedings of the National Academy of Sciences, 117(11), 5749-5760.
https://doi.org/10.1073/pnas.1917421117, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53792
Zang, R., Case, J., Yutuc, E., Ma, X., Shen, S., Castro, M., Liu, Z., Zeng, Q., Zhao, H., Son, J., Rothlauf, P., Kreutzberger, A., Hou, G., Zhang, H., Bose, S., Wang, X., Vahey, M., Mani, K., Griffiths, W...., & Ding, S. (2020). Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proceedings of the National Academy of Sciences, 117(50), 32105-32113.
https://doi.org/10.1073/pnas.2012197117, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55583
Angelini, R., Yutuc, E., Wyatt, M., Newton, J., YUSUF, F., Griffiths, L., Cooze, B., Assad, D., Frache, G., Rao, W., Allen, L., Korade, Z., Nguyen, T., Rathnayake, R., Cologna, S., Howell, O., Clench, M., Wang, Y., & Griffiths, W. (2021). Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging. Analytical Chemistry, 93(11), 4932-4943.
https://doi.org/10.1021/acs.analchem.0c05399, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56326
http://dx.doi.org/10.1021/acs.analchem.0c05399
Yutuc, E., Dickson, A., Pacciarini, M., Griffiths, L., Baker, P., Connell, L., Öhman, A., Forsgren, L., Trupp, M., Vilarinho, S., Khalil, Y., Clayton, P., Sari, S., Dalgic, B., Höflinger, P., Schöls, L., Griffiths, W., & Wang, Y. (2021). Deep mining of oxysterols and cholestenoic acids in human plasma and cerebrospinal fluid: Quantification using isotope dilution mass spectrometry. Analytica Chimica Acta, 1154, 338259
https://doi.org/10.1016/j.aca.2021.338259, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56163
Griffiths, W., Abdel-Khalik, J., Moore, S., Wijeyekoon, R., Crick, P., Yutuc, E., Farrell, K., Breen, D., Williams-Gray, C., Theofilopoulos, S., Arenas, E., Trupp, M., Barker, R., & Wang, Y. (2021). The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features. Frontiers in Aging Neuroscience, 13, 685594
https://doi.org/10.3389/fnagi.2021.685594, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57043
Wang, Y., Yutuc, E., & Griffiths, W. (2021). Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors. British Journal of Pharmacology, 178(16), 3176-3193.
https://doi.org/10.1111/bph.15191, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54644
Wang, Y., Yutuc, E., & Griffiths, W. (2021). Cholesterol metabolism pathways – are the intermediates more important than the products?. The FEBS Journal, 288(12), 3727-3745.
https://doi.org/10.1111/febs.15727, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56158
Höflinger, P., Hauser, S., Yutuc, E., Hengel, H., Griffiths, L., Radelfahr, F., Howell, O., Wang, Y., Connor, S., Duell, P., DeBarber, A., Martus, P., Lütjohann, D., Griffiths, W., & Schöls, L. (2021). Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis. Journal of Lipid Research, 62, 100078
https://doi.org/10.1016/j.jlr.2021.100078, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56747
Abdel-Khalik, J., Hearn, T., Dickson, A., Crick, P., Yutuc, E., Austin-Muttitt, K., Bigger, B., Morris, A., Shackleton, C., Clayton, P., Iida, T., Sircar, R., Rohatgi, R., Marschall, H., Sjövall, J., Björkhem, I., Mullins, J., Griffiths, W., & Wang, Y. (2021). Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates. The Journal of Steroid Biochemistry and Molecular Biology, 206, 105794
https://doi.org/10.1016/j.jsbmb.2020.105794, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55690
Wang, Y., Yutuc, E., & Griffiths, W. (2020). Standardizing and increasing the utility of lipidomics: a look to the next decade. Expert Review of Proteomics, 17(10), 699-717.
https://doi.org/10.1080/14789450.2020.1847086, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55597
Hudson, N., Reverter, A., Griffiths, W., Yutuc, E., Wang, Y., Jeanes, A., McWilliam, S., Pethick, D., & Greenwood, P. (2020). Gene expression identifies metabolic and functional differences between intramuscular and subcutaneous adipocytes in cattle. BMC Genomics, 21(1)
https://doi.org/10.1186/s12864-020-6505-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53490
Griffiths, W., Yutuc, E., Davies, D., Dickson, A., Angelini, R., Assad, D., Frache, G., & Wang, Y. (2020). CHAPTER 1. Lipidomics Basics. New Developments in Mass Spectrometry (pp. 1-24). Royal Society of Chemistry
https://doi.org/10.1039/9781788013109-00001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53525
Yutuc, E., Griffiths, W., Yutuc, E., Abdel-Khalik, J., Crick, P., Hearn, T., Dickson, A., Bigger, B., Wu, T., Goenka, A., Ghosh, A., Jones, S., Covey, D., Ory, D., & Wang, Y. (2019). Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders. Free Radical Biology and Medicine
https://doi.org/10.1016/j.freeradbiomed.2019.04.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50061
Yutuc, E., Crick, P., Yutuc, E., Abdel-Khalik, J., Saeed, A., Betsholtz, C., Genove, G., Björkhem, I., Wang, Y., & Griffiths, W. (2019). Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse. The Journal of Steroid Biochemistry and Molecular Biology, 195, 105475
https://doi.org/10.1016/j.jsbmb.2019.105475, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51994
Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., & Griffiths, W. (2019). Imaging Sterols and Oxysterols in Mouse Brain Reveals Distinct Spatial Cholesterol Metabolism
https://doi.org/10.1101/450973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53208
Griffiths, W., Abdel-Khalik, J., Yutuc, E., Roman, G., Warner, M., Gustafsson, J., & Wang, Y. (2019). Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients. Free Radical Biology and Medicine, 134, 42-52.
https://doi.org/10.1016/j.freeradbiomed.2018.12.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48010
Meljon, A., Crick, P., Yutuc, E., Yau, J., Seckl, J., Theofilopoulos, S., Arenas, E., Wang, Y., & Griffiths, W. (2019). Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5. Biomolecules, 9(4), 149
https://doi.org/10.3390/biom9040149, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50029
Yutuc, E., Abdel-Khalik, J., Crick, P., Yutuc, E., Wang, Y., & Griffiths, W. (2019). Developing an Enzyme-Assisted Derivatization Method for Analysis of C27 Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry. Molecules, 24(3), 597
https://doi.org/10.3390/molecules24030597, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48910
Theofilopoulos, S., Oliveira, W., Yang, S., Yutuc, E., Saeed, A., Abdel-Khalik, J., Ullgren, A., Cedazo-Minguez, A., Björkhem, I., Wang, Y., Griffiths, W., & Arenas, E. (2019). 24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo. Journal of Biological Chemistry, 294(11), 4169-4176.
https://doi.org/10.1074/jbc.ra118.005639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48277
http://dx.doi.org/10.1074/jbc.ra118.005639
Griffiths, W., Crick, P., Meljon, A., Theofilopoulos, S., Abdel-Khalik, J., Yutuc, E., Parker, J., Kelly, D., Kelly, S., Arenas, E., & Wang, Y. (2019). Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1864(2), 191-211.
https://doi.org/10.1016/j.bbalip.2018.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa46057
http://dx.doi.org/10.1016/j.bbalip.2018.11.006
Abdel-Khalik, J., Crick, P., Yutuc, E., DeBarber, A., Duell, P., Steiner, R., Laina, I., Wang, Y., & Griffiths, W. (2018). Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma. Biochimie
https://doi.org/10.1016/j.biochi.2018.06.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40916
Griffiths, W., Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Howell, O., & Wang, Y. (2018). Imaging Oxysterols in Mouse Brain by On-Tissue Derivatisation-Robotic Liquid Micro-Extraction Surface Analysis-Liquid Chromatography Mass Spectrometry
https://doi.org/10.1101/450973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48402
Griffiths, W., Abdel-Khalik, J., Crick, P., Yutuc, E., Ogundare, M., Bigger, B., Morris, A., Shackleton, C., Clayton, P., Iida, T., Sircar, R., Marschall, H., Sjoval, J., Bjorkhem, I., Rohatgi, R., & Wang, Y. (2018). Bile Acid Biosynthesis Avoiding Cholesterol
https://doi.org/10.1101/385419, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48403
Griffiths, W., Gilmore, I., Yutuc, E., Abdel-Khalik, J., Crick, P., Hearn, T., Dickson, A., Bigger, B., Wu, T., Goenka, A., Ghosh, A., Jones, S., & Wang, Y. (2018). Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation. Journal of Lipid Research, 59(6), 1058-1070.
https://doi.org/10.1194/jlr.d083246, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39367
Griffiths, W., Hearn, T., Crick, P., Abdel-Khalik, J., Dickson, A., Yutuc, E., & Wang, Y. (2017). Charge-tagging liquid chromatography–mass spectrometry methodology targeting oxysterol diastereoisomers. Chemistry and Physics of Lipids, 207, 69-80.
https://doi.org/10.1016/j.chemphyslip.2017.04.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32978
Griffiths, W., Abdel-Khalik, J., Yutuc, E., Morgan, A., Gilmore, I., Hearn, T., & Wang, Y. (2017). Cholesterolomics: An update. Analytical Biochemistry
https://doi.org/10.1016/j.ab.2017.01.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31729
Abdel-Khalik, J., Yutuc, E., Crick, P., Gustafsson, J., Warner, M., Roman, G., Talbot, K., Gray, E., Griffiths, W., Turner, M., & Wang, Y. (2017). Defective cholesterol metabolism in amyotrophic lateral sclerosis. Journal of Lipid Research, jlr.P071639
https://doi.org/10.1194/jlr.P071639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30987
Robertson, K., Hsieh, W., Forster, T., Blanc, M., Lu, H., Crick, P., Yutuc, E., Watterson, S., Martin, K., Griffiths, S., Enright, A., Yamamoto, M., Pradeepa, M., Lennox, K., Behlke, M., Talbot, S., Haas, J., Dölken, L., Griffiths, W...., & Ghazal, P. (2016). An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway. PLOS Biology, 14(3), e1002364
https://doi.org/10.1371/journal.pbio.1002364, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27043
Griffiths, W., Abdel-Khalik, J., Crick, P., Yutuc, E., & Wang, Y. (2016). New methods for analysis of oxysterols and related compounds by LC–MS. The Journal of Steroid Biochemistry and Molecular Biology, 162, 4-26.
https://doi.org/10.1016/j.jsbmb.2015.11.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25192
Griffiths, W., Abdel-Khalik, J., Hearn, T., Yutuc, E., Morgan, A., Wang, Y., Griffiths, W., Wang, Y., Morgan, A., & Yutuc, E. (2016). Current trends in oxysterol research. Biochemical Society Transactions, 44(2), 652-658.
https://doi.org/10.1042/BST20150255, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27117
Angelini, R., Yutuc, E., Wyatt, M., Newton, J., Yusuf, F., Griffiths, L., Cooze, B., Assad, D., Frache, G., Rao, W., Allen, L., Korade, Z., Nguyen, T., Rathnayake, R., Cologna, S., Howell, O., Clench, M., Wang, Y., & Griffiths, W. (2020). Visualising Cholesterol in Brain by On-Tissue Derivatisation and Quantitative Mass Spectrometry Imaging. bioRxiv
https://doi.org/10.1101/2020.11.06.369447, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60125
Hennegan, J., Bryant, A., Griffiths, L., Trigano, M., Bartley, O., Bartlett, J., Minahan, C., Oliveira, W., Yutuc, E., Ntikas, S., Bartsocas, C., Markouri, M., Antoniadou, E., Laina, I., Howell, O., Li, M., Wang, Y., Griffiths, W., Lane, E...., & Theofilopoulos, S. (2024). Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development. iScience, 27(1), 108670
https://doi.org/10.1016/j.isci.2023.108670, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65068
Griffiths, W., Yutuc, E., & Wang, Y. (2023). Mass Spectrometry Imaging of Cholesterol and Oxysterols. Implication of Oxysterols and Phytosterols in Aging and Human Diseases (pp. 73-87). Springer International Publishing
https://doi.org/10.1007/978-3-031-43883-7_5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64898
Griffiths, W., Yutuc, E., Ali Asgari, M., & Wang, Y. (2023). Role of Bile Acid Pathway Intermediates in Pathology of CTX
https://doi.org/10.5281/zenodo.10050199, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64910
Dickson, A., Yutuc, E., Thornton, C., Dunford, J., Oppermann, U., Wang, Y., & Griffiths, W. (2023). HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta. Open Biology, 13(5)
https://doi.org/10.1098/rsob.220313, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61629
http://dx.doi.org/10.1098/rsob.220313
Dickson, A., Yutuc, E., Thornton, C., Wang, Y., & Griffiths, W. (2022). Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry. Frontiers in Endocrinology, 13
https://doi.org/10.3389/fendo.2022.1031013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61630
Haider, A., Zhao, C., Wang, L., Xiao, Z., Rong, J., Xia, X., Chen, Z., Pfister, S., Mast, N., Yutuc, E., Chen, J., Li, Y., Shao, T., Warnock, G., Dawoud, A., Connors, T., Oakley, D., Wei, H., Wang, J...., & Liang, S. (2022). Assessment of cholesterol homeostasis in the living human brain. Science Translational Medicine, 14(665)
https://doi.org/10.1126/scitranslmed.adc9967, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61471
Yutuc, E. (2017). Analysis of Sterols in Human T Helper Cells
https://doi.org/10.23889/SUthesis.60641, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60641
Griffiths, L., Hawkins, K., Yutuc, E., Angelini, R., Fosuah, R., Pacciarini, M., Dickson, A., Robertson, N., Childs, L., Loveless, S., Tallantyre, E., Griffiths, W., Wang, Y., & Howell, O. (2025). Sterol imbalances and cholesterol‐24‐hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis. Brain Pathology, 35(5), e70001
https://doi.org/10.1111/bpa.70001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68901
Griffiths, W., Yutuc, E., Ali Asgari, M., & Wang, Y. (n.d.) Role of Bile Acid Pathway Intermediates in Pathology of Cerebrotendinous Xanthomatosis (CTX). In Antonio Federico, Andrea E. DeBarber, Tzipora C. Falik-Zaccai, Hidde H. Huidekoper, Robert D. Steiner (Ed.), Cerebrotendinous Xanthomatosis: A Treatable Rare Neurometabolic Disorder (pp. 144-155). Springer
https://doi.org/10.1007/978-3-031-92526-9_12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa69494
Ali Asgari, M., Yutuc, E., Abdel-Khalik, J., Crick, P., Morris, A., Jones, S., Ghosh, A., Curnock, R., Hart, C., Schöls, L., Matysik, S., Laina, I., Reid, E., Warner, T., Gonzalez-Herrero, B., Silva, R., Pickrell, O., Moat, S., Griffiths, W., & Wang, Y. (n.d.) Rare Cholesterol Related Disorders – A Sterolomic Library for Diagnosis and Monitoring of Diseases. medRxiv
https://doi.org/10.1101/2025.06.23.25328695, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa69955
Yutuc, E., Ghosh, A., Abdel-Khalik, J., Goenka, A., Ali Asgari, M., Lopez-Castejon, G., Beaman, G., Wynn, R., Newman, W., Jones, S., Griffiths, W., & Wang, Y. (2025). Deletion of CH25H and LIPA Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7α,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant. medRxiv
https://doi.org/10.1101/2025.07.29.25330953, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa70079

All Research

Journal Articles

Griffiths, L., Hawkins, K., Yutuc, E., Angelini, R., Fosuah, R., Pacciarini, M., Dickson, A., Robertson, N., Childs, L., Loveless, S., Tallantyre, E., Griffiths, W., Wang, Y., & Howell, O. (2025). Sterol imbalances and cholesterol‐24‐hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis. Brain Pathology, 35(5), e70001
https://doi.org/10.1111/bpa.70001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68901
Yutuc, E., Ghosh, A., Abdel-Khalik, J., Goenka, A., Ali Asgari, M., Lopez-Castejon, G., Beaman, G., Wynn, R., Newman, W., Jones, S., Griffiths, W., & Wang, Y. (2025). Deletion of CH25H and LIPA Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7α,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant. medRxiv
https://doi.org/10.1101/2025.07.29.25330953, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa70079
Hennegan, J., Bryant, A., Griffiths, L., Trigano, M., Bartley, O., Bartlett, J., Minahan, C., Oliveira, W., Yutuc, E., Ntikas, S., Bartsocas, C., Markouri, M., Antoniadou, E., Laina, I., Howell, O., Li, M., Wang, Y., Griffiths, W., Lane, E...., & Theofilopoulos, S. (2024). Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development. iScience, 27(1), 108670
https://doi.org/10.1016/j.isci.2023.108670, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65068
Dickson, A., Yutuc, E., Thornton, C., Dunford, J., Oppermann, U., Wang, Y., & Griffiths, W. (2023). HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta. Open Biology, 13(5)
https://doi.org/10.1098/rsob.220313, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61629
http://dx.doi.org/10.1098/rsob.220313
Dickson, A., Yutuc, E., Thornton, C., Wang, Y., & Griffiths, W. (2022). Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry. Frontiers in Endocrinology, 13
https://doi.org/10.3389/fendo.2022.1031013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61630
Haider, A., Zhao, C., Wang, L., Xiao, Z., Rong, J., Xia, X., Chen, Z., Pfister, S., Mast, N., Yutuc, E., Chen, J., Li, Y., Shao, T., Warnock, G., Dawoud, A., Connors, T., Oakley, D., Wei, H., Wang, J...., & Liang, S. (2022). Assessment of cholesterol homeostasis in the living human brain. Science Translational Medicine, 14(665)
https://doi.org/10.1126/scitranslmed.adc9967, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61471
Griffiths, W., Abdel-Khalik, J., Moore, S., Wijeyekoon, R., Crick, P., Yutuc, E., Farrell, K., Breen, D., Williams-Gray, C., Theofilopoulos, S., Arenas, E., Trupp, M., Barker, R., & Wang, Y. (2021). The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features. Frontiers in Aging Neuroscience, 13, 685594
https://doi.org/10.3389/fnagi.2021.685594, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57043
Wang, Y., Yutuc, E., & Griffiths, W. (2021). Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors. British Journal of Pharmacology, 178(16), 3176-3193.
https://doi.org/10.1111/bph.15191, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54644
Wang, Y., Yutuc, E., & Griffiths, W. (2021). Cholesterol metabolism pathways – are the intermediates more important than the products?. The FEBS Journal, 288(12), 3727-3745.
https://doi.org/10.1111/febs.15727, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56158
Höflinger, P., Hauser, S., Yutuc, E., Hengel, H., Griffiths, L., Radelfahr, F., Howell, O., Wang, Y., Connor, S., Duell, P., DeBarber, A., Martus, P., Lütjohann, D., Griffiths, W., & Schöls, L. (2021). Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis. Journal of Lipid Research, 62, 100078
https://doi.org/10.1016/j.jlr.2021.100078, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56747
Yutuc, E., Dickson, A., Pacciarini, M., Griffiths, L., Baker, P., Connell, L., Öhman, A., Forsgren, L., Trupp, M., Vilarinho, S., Khalil, Y., Clayton, P., Sari, S., Dalgic, B., Höflinger, P., Schöls, L., Griffiths, W., & Wang, Y. (2021). Deep mining of oxysterols and cholestenoic acids in human plasma and cerebrospinal fluid: Quantification using isotope dilution mass spectrometry. Analytica Chimica Acta, 1154, 338259
https://doi.org/10.1016/j.aca.2021.338259, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56163
Angelini, R., Yutuc, E., Wyatt, M., Newton, J., YUSUF, F., Griffiths, L., Cooze, B., Assad, D., Frache, G., Rao, W., Allen, L., Korade, Z., Nguyen, T., Rathnayake, R., Cologna, S., Howell, O., Clench, M., Wang, Y., & Griffiths, W. (2021). Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging. Analytical Chemistry, 93(11), 4932-4943.
https://doi.org/10.1021/acs.analchem.0c05399, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56326
http://dx.doi.org/10.1021/acs.analchem.0c05399
Abdel-Khalik, J., Hearn, T., Dickson, A., Crick, P., Yutuc, E., Austin-Muttitt, K., Bigger, B., Morris, A., Shackleton, C., Clayton, P., Iida, T., Sircar, R., Rohatgi, R., Marschall, H., Sjövall, J., Björkhem, I., Mullins, J., Griffiths, W., & Wang, Y. (2021). Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates. The Journal of Steroid Biochemistry and Molecular Biology, 206, 105794
https://doi.org/10.1016/j.jsbmb.2020.105794, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55690
Zang, R., Case, J., Yutuc, E., Ma, X., Shen, S., Castro, M., Liu, Z., Zeng, Q., Zhao, H., Son, J., Rothlauf, P., Kreutzberger, A., Hou, G., Zhang, H., Bose, S., Wang, X., Vahey, M., Mani, K., Griffiths, W...., & Ding, S. (2020). Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proceedings of the National Academy of Sciences, 117(50), 32105-32113.
https://doi.org/10.1073/pnas.2012197117, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55583
Wang, Y., Yutuc, E., & Griffiths, W. (2020). Standardizing and increasing the utility of lipidomics: a look to the next decade. Expert Review of Proteomics, 17(10), 699-717.
https://doi.org/10.1080/14789450.2020.1847086, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55597
Hudson, N., Reverter, A., Griffiths, W., Yutuc, E., Wang, Y., Jeanes, A., McWilliam, S., Pethick, D., & Greenwood, P. (2020). Gene expression identifies metabolic and functional differences between intramuscular and subcutaneous adipocytes in cattle. BMC Genomics, 21(1)
https://doi.org/10.1186/s12864-020-6505-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53490
Angelini, R., Yutuc, E., Wyatt, M., Newton, J., Yusuf, F., Griffiths, L., Cooze, B., Assad, D., Frache, G., Rao, W., Allen, L., Korade, Z., Nguyen, T., Rathnayake, R., Cologna, S., Howell, O., Clench, M., Wang, Y., & Griffiths, W. (2020). Visualising Cholesterol in Brain by On-Tissue Derivatisation and Quantitative Mass Spectrometry Imaging. bioRxiv
https://doi.org/10.1101/2020.11.06.369447, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60125
Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., & Griffiths, W. (2020). Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism. Proceedings of the National Academy of Sciences, 117(11), 5749-5760.
https://doi.org/10.1073/pnas.1917421117, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53792
Yutuc, E., Griffiths, W., Yutuc, E., Abdel-Khalik, J., Crick, P., Hearn, T., Dickson, A., Bigger, B., Wu, T., Goenka, A., Ghosh, A., Jones, S., Covey, D., Ory, D., & Wang, Y. (2019). Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders. Free Radical Biology and Medicine
https://doi.org/10.1016/j.freeradbiomed.2019.04.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50061
Yutuc, E., Crick, P., Yutuc, E., Abdel-Khalik, J., Saeed, A., Betsholtz, C., Genove, G., Björkhem, I., Wang, Y., & Griffiths, W. (2019). Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse. The Journal of Steroid Biochemistry and Molecular Biology, 195, 105475
https://doi.org/10.1016/j.jsbmb.2019.105475, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51994
Griffiths, W., Abdel-Khalik, J., Yutuc, E., Roman, G., Warner, M., Gustafsson, J., & Wang, Y. (2019). Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients. Free Radical Biology and Medicine, 134, 42-52.
https://doi.org/10.1016/j.freeradbiomed.2018.12.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48010
Meljon, A., Crick, P., Yutuc, E., Yau, J., Seckl, J., Theofilopoulos, S., Arenas, E., Wang, Y., & Griffiths, W. (2019). Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5. Biomolecules, 9(4), 149
https://doi.org/10.3390/biom9040149, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50029
Yutuc, E., Abdel-Khalik, J., Crick, P., Yutuc, E., Wang, Y., & Griffiths, W. (2019). Developing an Enzyme-Assisted Derivatization Method for Analysis of C27 Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry. Molecules, 24(3), 597
https://doi.org/10.3390/molecules24030597, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48910
Theofilopoulos, S., Oliveira, W., Yang, S., Yutuc, E., Saeed, A., Abdel-Khalik, J., Ullgren, A., Cedazo-Minguez, A., Björkhem, I., Wang, Y., Griffiths, W., & Arenas, E. (2019). 24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo. Journal of Biological Chemistry, 294(11), 4169-4176.
https://doi.org/10.1074/jbc.ra118.005639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48277
http://dx.doi.org/10.1074/jbc.ra118.005639
Griffiths, W., Crick, P., Meljon, A., Theofilopoulos, S., Abdel-Khalik, J., Yutuc, E., Parker, J., Kelly, D., Kelly, S., Arenas, E., & Wang, Y. (2019). Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1864(2), 191-211.
https://doi.org/10.1016/j.bbalip.2018.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa46057
http://dx.doi.org/10.1016/j.bbalip.2018.11.006
Abdel-Khalik, J., Crick, P., Yutuc, E., DeBarber, A., Duell, P., Steiner, R., Laina, I., Wang, Y., & Griffiths, W. (2018). Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma. Biochimie
https://doi.org/10.1016/j.biochi.2018.06.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40916
Griffiths, W., Gilmore, I., Yutuc, E., Abdel-Khalik, J., Crick, P., Hearn, T., Dickson, A., Bigger, B., Wu, T., Goenka, A., Ghosh, A., Jones, S., & Wang, Y. (2018). Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation. Journal of Lipid Research, 59(6), 1058-1070.
https://doi.org/10.1194/jlr.d083246, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39367
Griffiths, W., Hearn, T., Crick, P., Abdel-Khalik, J., Dickson, A., Yutuc, E., & Wang, Y. (2017). Charge-tagging liquid chromatography–mass spectrometry methodology targeting oxysterol diastereoisomers. Chemistry and Physics of Lipids, 207, 69-80.
https://doi.org/10.1016/j.chemphyslip.2017.04.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32978
Griffiths, W., Abdel-Khalik, J., Yutuc, E., Morgan, A., Gilmore, I., Hearn, T., & Wang, Y. (2017). Cholesterolomics: An update. Analytical Biochemistry
https://doi.org/10.1016/j.ab.2017.01.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31729
Abdel-Khalik, J., Yutuc, E., Crick, P., Gustafsson, J., Warner, M., Roman, G., Talbot, K., Gray, E., Griffiths, W., Turner, M., & Wang, Y. (2017). Defective cholesterol metabolism in amyotrophic lateral sclerosis. Journal of Lipid Research, jlr.P071639
https://doi.org/10.1194/jlr.P071639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30987
Robertson, K., Hsieh, W., Forster, T., Blanc, M., Lu, H., Crick, P., Yutuc, E., Watterson, S., Martin, K., Griffiths, S., Enright, A., Yamamoto, M., Pradeepa, M., Lennox, K., Behlke, M., Talbot, S., Haas, J., Dölken, L., Griffiths, W...., & Ghazal, P. (2016). An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway. PLOS Biology, 14(3), e1002364
https://doi.org/10.1371/journal.pbio.1002364, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27043
Griffiths, W., Abdel-Khalik, J., Crick, P., Yutuc, E., & Wang, Y. (2016). New methods for analysis of oxysterols and related compounds by LC–MS. The Journal of Steroid Biochemistry and Molecular Biology, 162, 4-26.
https://doi.org/10.1016/j.jsbmb.2015.11.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25192
Griffiths, W., Abdel-Khalik, J., Hearn, T., Yutuc, E., Morgan, A., Wang, Y., Griffiths, W., Wang, Y., Morgan, A., & Yutuc, E. (2016). Current trends in oxysterol research. Biochemical Society Transactions, 44(2), 652-658.
https://doi.org/10.1042/BST20150255, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27117
Ali Asgari, M., Yutuc, E., Abdel-Khalik, J., Crick, P., Morris, A., Jones, S., Ghosh, A., Curnock, R., Hart, C., Schöls, L., Matysik, S., Laina, I., Reid, E., Warner, T., Gonzalez-Herrero, B., Silva, R., Pickrell, O., Moat, S., Griffiths, W., & Wang, Y. (n.d.) Rare Cholesterol Related Disorders – A Sterolomic Library for Diagnosis and Monitoring of Diseases. medRxiv
https://doi.org/10.1101/2025.06.23.25328695, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa69955

Book Chapters

Griffiths, W., Yutuc, E., & Wang, Y. (2023). Mass Spectrometry Imaging of Cholesterol and Oxysterols. Implication of Oxysterols and Phytosterols in Aging and Human Diseases (pp. 73-87). Springer International Publishing
https://doi.org/10.1007/978-3-031-43883-7_5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64898
Griffiths, W., Yutuc, E., Davies, D., Dickson, A., Angelini, R., Assad, D., Frache, G., & Wang, Y. (2020). CHAPTER 1. Lipidomics Basics. New Developments in Mass Spectrometry (pp. 1-24). Royal Society of Chemistry
https://doi.org/10.1039/9781788013109-00001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53525
Griffiths, W., Yutuc, E., Ali Asgari, M., & Wang, Y. (n.d.) Role of Bile Acid Pathway Intermediates in Pathology of Cerebrotendinous Xanthomatosis (CTX). In Antonio Federico, Andrea E. DeBarber, Tzipora C. Falik-Zaccai, Hidde H. Huidekoper, Robert D. Steiner (Ed.), Cerebrotendinous Xanthomatosis: A Treatable Rare Neurometabolic Disorder (pp. 144-155). Springer
https://doi.org/10.1007/978-3-031-92526-9_12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa69494

Other Research Outputs

Griffiths, W., Yutuc, E., Ali Asgari, M., & Wang, Y. (2023). Role of Bile Acid Pathway Intermediates in Pathology of CTX
https://doi.org/10.5281/zenodo.10050199, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64910
Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Skibinski, D., Howell, O., Wang, Y., & Griffiths, W. (2019). Imaging Sterols and Oxysterols in Mouse Brain Reveals Distinct Spatial Cholesterol Metabolism
https://doi.org/10.1101/450973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53208
Griffiths, W., Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., Clench, M., Howell, O., & Wang, Y. (2018). Imaging Oxysterols in Mouse Brain by On-Tissue Derivatisation-Robotic Liquid Micro-Extraction Surface Analysis-Liquid Chromatography Mass Spectrometry
https://doi.org/10.1101/450973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48402
Griffiths, W., Abdel-Khalik, J., Crick, P., Yutuc, E., Ogundare, M., Bigger, B., Morris, A., Shackleton, C., Clayton, P., Iida, T., Sircar, R., Marschall, H., Sjoval, J., Bjorkhem, I., Rohatgi, R., & Wang, Y. (2018). Bile Acid Biosynthesis Avoiding Cholesterol
https://doi.org/10.1101/385419, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48403
Yutuc, E. (2017). Analysis of Sterols in Human T Helper Cells
https://doi.org/10.23889/SUthesis.60641, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60641

Taught Modules

PM-138 Skills for being a Medical Scientist

The aim of this module is to provide students with an initial experience of what it is to be a modern medical scientist, from the initial experimental planning, to performing experiments within the laboratory with data acquisition and analysis and finally to the communication of scientific findings to a wider audience. Students will develop basic skill sets in the four most important research skill areas of practical laboratory skills, data analysis, collaboration and communication. The module will be both theoretical and applied, where the student will be instructed in methods essential for data acquisition and data analyses but will also actively participate in the laboratory, using broadly applicable experimental techniques. In addition, students will learn about health and safety within a laboratory environment and the current ethics regulations surrounding the use of humans, human tissue and animals within medical research. Furthermore, students will develop their communication skill sets not only through essay writing but also will develop their oral presentation skill set and their collaboration skills through a group presentation and tutorial classes.
PM-138C Sgiliau ar gyfer Gwyddorau Meddygol

Nod y modiwl hwn yw cynnig profiad cychwynnol i fyfyrwyr o waith gwyddonydd meddygol modern, o gamau cychwynnol cynllunio arbrofion, i gynnal arbrofion mewn labordy ynghyd â chasglu a dadansoddi data ac, yn olaf, gyfleu'r canfyddiadau gwyddonol i gynulleidfa ehangach. Bydd myfyrwyr yn datblygu set o sgiliau sylfaenol yn y pedwar maes sgiliau ymchwil pwysicaf sef sgiliau labordy ymarferol, dadansoddi data, cydweithio a chyfathrebu. Bydd y modiwl hwn yn un damcaniaethol a chymhwysol, lle bydd myfyrwyr yn cael eu hyfforddi mewn dulliau sy'n hanfodol ar gyfer casglu a dadansoddi data ond hefyd bydd disgwyl iddynt gymryd rhan yn y labordy, gan ddefnyddio dulliau arbrofol â chymhwysiad eang. Yn ogystal, bydd myfyrwyr yn dysgu am iechyd a diogelwch mewn amgylchedd labordy a'r rheoliadau moeseg presennol o ran y defnydd o bobl, meinwe dynol ac anifeiliaid mewn ymchwil feddygol. Ar ben hynny, bydd myfyrwyr yn datblygu eu set o sgiliau cyfathrebu nid yn unig drwy ysgrifennu traethodau ond byddant hefyd yn datblygu eu sgiliau cyflwyno llafar a'u sgiliau cydweithio drwy gyflwyniad gr¿p a dosbarthiadau tiwtorial.
PM-162 Organic and Analytical Chemistry: an Introduction for Life Sciences

This module covers the fundamentals of organic chemistry, with a focus on stereochemistry and the mechanisms behind organic reactions. Additionally, it introduces analytical chemistry principles, emphasizing key instrumental techniques for both quantitative and qualitative analysis, as well as structure elucidation.
PM-277 Techniques in Molecular Biology

The module will provide a sound theoretical basis to a comprehensive range of biomolecular techniques currently employed in molecular genetics and biochemistry. Particular emphasis is placed on DNA recombinant technology, next generation sequencing, gene expression detection, transcriptomics, proteomics and mass spectrometry.
PM-277C Technegau Bioleg Foleciwlaidd

Bydd y modiwl yn cynnig sylfaen ddamcaniaethol gadarn ar gyfer ystod gynhwysfawr o dechnegau biofoleciwlaidd a ddefnyddir ar hyn o bryd mewn geneteg foleciwlaidd a biocemeg. Rhoddir pwyslais penodol ar dechnoleg ailgyfuno DNA, dilyniannu cenhedlaeth nesaf, canfod mynegiad genynnau, trawsgriptomeg, proteomeg a sbectrometreg màs.
PM-280 Skills for Researchers

The modern scientist graduate is expected to have gained extensive laboratory-based experience and this is certainly essential for any student intent on pursuing a research-based career. Skills for Researchers provides students with the opportunity to acquire the core skills to be able to conduct, analyse, interpret and present scientific experiments. A proportion of the module will be spent in the laboratory gaining hands-on experience. Skills acquired in this module will form the basis for future experimental work, including the final year project. Students will have the opportunity to provide feedback to peers and engage with a variety of online learning materials.
PM-293 Neuroscience & Neurology

This module offers an integrated exploration of the nervous system by drawing on key concepts from cell biology, physiology, and biochemistry. Focusing on the structure and function of the human central and peripheral nervous systems, it bridges foundational neuroscience with clinical neurology. Students will examine both normal neural function and the pathophysiology of common neurological disorders, spanning molecular and cellular mechanisms to whole-system processes. Emphasis is placed on critical engagement with current scientific literature, encouraging students to assess established knowledge alongside emerging research. The module is delivered by a multidisciplinary team of neuroscientists and clinical neurologists, providing both theoretical insight and real-world clinical relevance.
PM-293C Niwrowyddoniaeth a Niwroleg

Mae'r modiwl hwn yn cynnig archwiliad integredig o'r system nerfol gan dynnu ar gysyniadau craidd o fioleg celloedd, ffisioleg a biocemeg. Gan ganolbwyntio ar strwythur a gweithrediad systemau nerfol canolog a pherifferol dynol, mae'n pontio niwrowyddoniaeth sylfaenol a niwroleg glinigol. Bydd myfyrwyr yn archwilio gweithrediad niwral normal a phathoffisioleg cyflyrau niwrolegol cyffredin, sy'n cynnwys mecanweithiau moleciwlaidd a chellol i brosesau system gyfan. Rhoddir pwyslais ar ymgysylltu'n feirniadol â llenyddiaeth wyddonol gyfoes, gan annog myfyrwyr i asesu gwybodaeth sefydledig ochr yn ochr ag ymchwil sydd ar ddod. Mae'r modiwl yn cael ei gyflwyno gan dîm rhyngddisgyblaethol o niwrowyddonwyr a niwrolegwyr clinigol, gan ddarparu gwybodaeth ddamcaniaethol a pherthnasedd clinigol y byd go iawn.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PMLM22 Laboratory Measurement Techniques for Medical Sciences

This module will enable students to understand the basic and advanced concepts of laboratory and measurement techniques used in medical sciences, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.
PMNM19 Diagnostics and Imaging

Nanotechnology may lead to more rapid diagnostic tests, implantable devices, point of care instruments and improved medical imaging. This module will explore the application of nanotechnology to various medical techniques, focusing on novel research devices, pre-clinical tools and emerging technology within hospitals.

Dr Eylan Yutuc

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Taught Modules

PM-138 Skills for being a Medical Scientist

PM-138C Sgiliau ar gyfer Gwyddorau Meddygol

PM-162 Organic and Analytical Chemistry: an Introduction for Life Sciences

PM-277 Techniques in Molecular Biology

PM-277C Technegau Bioleg Foleciwlaidd

PM-280 Skills for Researchers

PM-293 Neuroscience & Neurology

PM-293C Niwrowyddoniaeth a Niwroleg

PM-344 Capstone Project

PMLM22 Laboratory Measurement Techniques for Medical Sciences

PMNM19 Diagnostics and Imaging