Institute of Life Science 2 Internal Atrium

Professor Karl Hawkins

Professor

Biomedical Sciences

+44 (0) 1792 295058

k.m.hawkins@swansea.ac.uk

Office CNH - 009
Ground Floor
Institute of Life Science 2
Singleton Campus

Available For Postgraduate Supervision

Research Links

https://orcid.org/0000-0003-0174-4151

ResearchGate

About

Professor Karl Hawkins is a Director of the Centre for NanoHealth at SUMS. Karl's research interests include the development of novel biomarkers of blood coagulation through exploitation of advanced rheological techniques.  He is author of over 70 publications in international peer reviewed journals in the fields of fluid mechanics, medical devices and haematology. His research has been funded by EPSRC, MRC, HCRW, ESF, British Council, industrial companies and an RCUK fellowship. He is a Co-Investigator of several EPSRC grants (including the a Platform Grant in Engineering Blood Diagnostics) with a total value in excess of £6M and is the Principal Investigator of an EPSRC first grant award that is aiding the development of novel haemorheological techniques for the measurement of blood coagulation and subsequent breakdown. Karl is active in the rheology community having served as the elected Secretary of the British Society of Rheology and is a Director of the Institute of Non-Newtonian Fluid Mechanics.

Areas Of Expertise

Rheology and bio-rheology
Rheometry
Biopolymer gels
Haemo-compatibility of medical devices

Publications

Research Highlights

Lawrence, M., Obaid, D., Sabra, A., Whitley, J., Whitley, J., Quarry, R., Gopala Pillai, S., Chase, A., Smith, D., Williams, R., Hawkins, K., Morris, R., & Evans, A. (2023). The Impact of Patient Characteristics and Antiplatelet Regimes on Clot Microstructure in Patients Treated for ST Elevation Myocardial Infarction: Clot Microstructure can Evaluate Therapeutic Efficacy. Clinical and Applied Thrombosis/Hemostasis, 29, 107602962211315
https://doi.org/10.1177/10760296221131563, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63236
http://dx.doi.org/10.1177/10760296221131563
Watson, O., ZALDUA, J., Gopala Pillai, S., Whitley, J., Howard, M., Lawrence, M., Hawkins, K., Morris, K., & Evans, A. (2023). The efficacy of low molecular weight heparin is reduced in Covid-19. Clinical Hemorheology and Microcirculation, 84(3), 1-12.
https://doi.org/10.3233/ch-221635, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63235
http://dx.doi.org/10.3233/ch-221635
Watson, O., Gopala Pillai, S., Howard, M., Zaldua, J., Whitley, J., Burgess, B., Lawrence, M., Hawkins, K., Morris, K., & Evans, A. (2022). Impaired fibrinolysis in severe Covid-19 infection is detectable in early stages of the disease. Clinical Hemorheology and Microcirculation, 82(2), 183-191.
https://doi.org/10.3233/ch-221491, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61002
https://pubmed.ncbi.nlm.nih.gov/35694917/
Butcher, L., Zaldua, J., Carnicero, J., Hawkins, K., Whitley, J., Mothukuri, R., Evans, A., Morris, K., Pillai, S., & Erusalimsky, J. (2022). High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone. Respiratory Research, 23(1)
https://doi.org/10.1186/s12931-022-02220-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62071
Evans, V., Lawrence, M., Whitley, J., Johns, C., Gopala Pillai, S., Hawkins, K., Power, K., Morris, K., Williams, R., & Evans, A. (2022). The treatment effect of rivaroxaban on clot characteristics in patients who present acutely with first time deep vein thrombosis. Clinical Hemorheology and Microcirculation, 80(2), 139-151.
https://doi.org/10.3233/ch-201030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56606
Tarassoli, S., Jessop, Z., Jovic, T., Hawkins, K., & Whitaker, I. (2021). Candidate Bioinks for Extrusion 3D Bioprinting—A Systematic Review of the Literature. Frontiers in Bioengineering and Biotechnology, 9
https://doi.org/10.3389/fbioe.2021.616753, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56759
Thomas, B., Hambly, R., Weisel, J., Rauova, L., Badiei, N., Brown, R., Thornton, C., Williams, R., & Hawkins, K. (2020). Abnormal clot microstructure formed in blood containing HIT-like antibodies. Thrombosis Research, 193, 25-30.
https://doi.org/10.1016/j.thromres.2020.05.029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54403
Hawkins, K. & Curtis, D. (2020). Papers from the 2019 Institute of Non-Newtonian Fluid Mechanics Meeting in Lake Vyrnwy, Wales. Physics of Fluids, 32(4), 040401
https://doi.org/10.1063/5.0008256, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54103
Sabra, A., Lawrence, M., Curtis, D., Hawkins, K., Williams, R., & Evans, A. (2020). In vitro clot model to evaluate fibrin-thrombin effects on fractal dimension of incipient blood clot. Clinical Hemorheology and Microcirculation, 74(2), 147-153.
https://doi.org/10.3233/ch-190615, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51304
Jessop, Z., Al-Sabah, A., Gao, N., Kyle, S., Thomas, B., Badiei, N., Hawkins, K., & Whitaker, I. (2019). Printability of pulp derived crystal, fibril and blend nanocellulose-alginate bioinks for extrusion 3D bioprinting. Biofabrication, 11(4), 045006
https://doi.org/10.1088/1758-5090/ab0631, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51247
Kyle, S., Jessop, Z., Al-Sabah, A., Hawkins, K., Lewis, A., Maffeis, T., Charbonneau, C., Gazze, A., Francis, L., Iakovlev, M., Nelson, K., Eichhorn, S., & Whitaker, I. (2018). Characterization of pulp derived nanocellulose hydrogels using AVAP® technology. Carbohydrate Polymers, 198, 270-280.
https://doi.org/10.1016/j.carbpol.2018.06.091, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40840
Holder, A., Badiei, N., Hawkins, K., Wright, C., Williams, R., & Curtis, D. (2018). Control of collagen gel mechanical properties through manipulation of gelation conditions near the sol–gel transition. Soft Matter, 14, 574-580.
https://doi.org/10.1039/C7SM01933E, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36407
Radley, G., Pieper, I., Thomas, B., Hawkins, K., & Thornton, C. (2018). Artificial Shear Stress Effects on Leukocytes at a Biomaterial Interface. Artificial Organs
https://doi.org/10.1111/aor.13409, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49111
Lamer, T., Thomas, B., Curtis, D., Badiei, N., Williams, P., Hawkins, K., Williams, R., Hawkins, K., & Curtis, D. (2017). The application of large amplitude oscillatory stress in a study of fully formed fibrin clots. Physics of Fluids, 29(12), 121606
https://doi.org/10.1063/1.4999991, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35309
Hudson, R., Holder, A., Hawkins, K., Curtis, D., & Williams, R. (2017). An enhanced rheometer inertia correction procedure (ERIC) for the study of gelling systems using combined motor-transducer rheometers. Physics of Fluids, 29(12)
https://doi.org/10.1063/1.4993308, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35940
Hawkins, K. (2017). Preface to Special Topic: Papers from the Institute of Non-Newtonian Fluid Mechanics Meeting, Lake Vyrnwy, 2017. Physics of Fluids, 29(12), 121401
https://doi.org/10.1063/1.5018585, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38182
Jessop, Z., Al-Sabah, A., Gardiner, M., Combellack, E., Hawkins, K., & Whitaker, I. (2017). “3D Bioprinting for Reconstructive Surgery: Principles, Applications and Challenges”. Journal of Plastic, Reconstructive & Aesthetic Surgery
https://doi.org/10.1016/j.bjps.2017.06.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34593
Knowles, R., Lawrence, M., Ferreira, P., Hayman, M., D’Silva, L., Stanford, S., Sabra, A., Tucker, A., Hawkins, K., Williams, P., Warner, T., Evans, P., & Williams, R. (2017). Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties. Platelets, 1-9.
https://doi.org/10.1080/09537104.2017.1306039, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33740
Sabra, A., Lawrence, M., Aubrey, R., Obaid, D., Chase, A., Smith, D., Thomas, P., Storton, S., Davies, G., Hawkins, K., Williams, P., Morris, K., & Evans, A. (2017). Characterisation of clot microstructure properties in stable coronary artery disease. Open Heart, 4(2), e000562
https://doi.org/10.1136/openhrt-2016-000562, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37018
Burke, L., Mortimer, C., Curtis, D., Lewis, A., Williams, R., Hawkins, K., Maffeis, T., Wright, C., & Wright, C. (2017). In-situ synthesis of magnetic iron-oxide nanoparticle-nanofibre composites using electrospinning. Materials Science and Engineering: C, 70, 512-519.
https://doi.org/10.1016/j.msec.2016.09.014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29839
D׳Silva, L., Wilczynska, M., Lewis, K., Lawrence, M., Hawkins, K., Williams, R., Stanford, S., Davidson, S., Morris, K., & Evans, A. (2016). Altered clot microstructure detected in obstructive sleep apnoea hypopnoea syndrome. Sleep Science, 9(1), 14-19.
https://doi.org/10.1016/j.slsci.2016.02.175, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29370
Lawrence, M., Marsden, N., Kaczynski, J., Davies, G., Davies, N., Hawkins, K., Perumal, S., Brown, M., Morris, K., Davidson, S., Williams, P., Evans, P., Brown, R., & Evans, A. (2016). An Investigation Into the Effects of In Vitro Dilution With Different Colloid Resuscitation Fluids on Clot Microstructure Formation. Anesthesia & Analgesia, 1
https://doi.org/10.1213/ANE.0000000000001536, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30371
Davies, N., Llwyd, O., Brugniaux, J., Davies, G., Marley, C., Hodson, D., Lawrence, M., D'Silva, L., Morris, R., Hawkins, K., Williams, R., Bailey, D., & Evans, A. (2016). Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals. Thrombosis Research, 143, 130-136.
https://doi.org/10.1016/j.thromres.2016.05.018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29486
Tassieri, M., Laurati, M., Curtis, D., Auhl, D., Coppola, S., Scalfati, A., Hawkins, K., Williams, R., & Cooper, J. (2016). i-Rheo: Measuring the materials' linear viscoelastic properties “in a step”!. Journal of Rheology, 60(4), 649-660.
https://doi.org/10.1122/1.4953443, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27484
Powell, L., Pritchard, M., Powell, L., Menzies, G., Lewis, P., Hawkins, K., Wright, C., Doull, I., Walsh, T., Onsøyen, E., Dessen, A., Myrvold, R., Rye, P., Myrset, A., Stevens, H., Hodges, L., MacGregor, G., Neilly, J., Hill, K...., & Wright, C. (2016). A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease. Molecular Pharmaceutics, 13(3), 863-872.
https://doi.org/10.1021/acs.molpharmaceut.5b00794, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26822
Lawrence, M., Marsden, N., Mothukuri, R., Morris, R., Davies, G., Hawkins, K., Curtis, D., Brown, M., Williams, P., Evans, P., Williams, R., Brown, R., & Evans, A. (2016). The Effects of Temperature on Clot Microstructure and Strength in Healthy Volunteers. Anesthesia & Analgesia, 122(1), 21-26.
https://doi.org/10.1213/ANE.0000000000000992, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27872
http://www.scopus.com/inward/record.url?eid=2-s2.0-84951567216&partnerID=MN8TOARS
Chan, C., Pieper, I., Hambly, R., Radley, G., Jones, A., Friedmann, Y., Hawkins, K., Westaby, S., Foster, G., & Thornton, C. (2015). The CentriMag Centrifugal Blood Pump as a Benchmark for In Vitro Testing of Hemocompatibility in Implantable Ventricular Assist Devices. Artificial Organs, 39(2), 93-101.
https://doi.org/10.1111/aor.12351, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18432
López-Aguilar, J., Webster, M., Al-Muslimawi, A., Tamaddon Jahromi, H., Williams, R., Hawkins, K., Askill, C., Ch’ng, C., Davies, G., Ebden, P., & Lewis, K. (2015). A computational extensional rheology study of two biofluid systems. Rheologica Acta, 54(4), 287-305.
https://doi.org/10.1007/s00397-014-0830-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29169
Broome, L., Davies, N., Harrison, N., Morris, R., Noble, S., Lawrence, M., D'Silva, L., Broome, L., Brown, R., Hawkins, K., Williams, R., Davidson, S., & Evans, A. (2015). Fractal dimension (df) as a new structural biomarker of clot microstructure in different stages of lung cancer. Thrombosis and Haemostasis, 114(6), 1251-1259.
https://doi.org/10.1160/TH15-04-0357, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22970
Davies, N., Harrison, N., Sabra, A., Lawrence, M., Noble, S., Davidson, S., Evans, V., Morris, R., Hawkins, K., Williams, P., Evans, P., Williams, R., Hawkins, K., Lawrence, M., Evans, A., & Davies, N. (2015). Application of ROTEM to assess hypercoagulability in patients with lung cancer. Thrombosis Research
https://doi.org/10.1016/j.thromres.2015.03.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20596
Stanford, S., Sabra, A., D’Silva, L., Lawrence, M., Morris, R., Storton, S., Brown, M., Evans, V., Hawkins, K., Williams, P., Davidson, S., Wani, M., Potter, J., Evans, P., Williams, R., Brown, R., & Evans, A. (2015). The changes in clot microstructure in patients with ischaemic stroke and the effects of therapeutic intervention: a prospective observational study. BMC Neurology, 15(1)
https://doi.org/10.1186/s12883-015-0289-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20524
González-Sánchez, M., Perni, S., Tommasi, G., Morris, N., Hawkins, K., López-Cabarcos, E., & Prokopovich, P. (2015). Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications. Materials Science and Engineering: C, 50, 332-340.
https://doi.org/10.1016/j.msec.2015.02.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20333
Badiei, N., Sowedan, A., Curtis, D., Brown, R., Lawrence, M., Campbell, A., Sabra, A., Evans, A., Weisel, J., Chernysh, I., Nagaswami, C., Williams, R., & Hawkins, K. (2015). Effects of unidirectional flow shear stresses on the formation, fractal microstructure and rigidity of incipient whole blood clots and fibrin gels. Clinical Hemorheology and Microcirculation, 60(4), 451-464.
https://doi.org/10.3233/ch-151924, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20275
Curtis, D., Holder, A., Badiei, N., Claypole, J., Walters, M., Thomas, B., Barrow, M., Deganello, D., Brown, R., Williams, R., & Hawkins, K. (2015). Validation of Optimal Fourier Rheometry for rapidly gelling materials and its application in the study of collagen gelation. Journal of Non-Newtonian Fluid Mechanics, 222, 253-259.
https://doi.org/10.1016/j.jnnfm.2015.01.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20273
http://dx.doi.org/10.1016/j.jnnfm.2015.01.003
Curtis, D., Badiei, N., Holder, A., Claypole, J., Deganello, D., Brown, R., Lawrence, M., Evans, A., Williams, R., & Hawkins, K. (2015). Assessment of the stress relaxation characteristics of critical gels formed under unidirectional shear flow by controlled stress parallel superposition rheometry. Journal of Non-Newtonian Fluid Mechanics, 222, 227-233.
https://doi.org/10.1016/j.jnnfm.2014.12.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20274
Lawrence, M., Sabra, A., Thomas, P., Obaid, D., D´Silva, L., Morris, R., Hawkins, K., Brown, R., Williams, R., Davidson, S., Chase, A., Smith, D., & Evans, A. (2015). Fractal dimension: A novel clot microstructure biomarker use in ST elevation myocardial infarction patients. Atherosclerosis, 240(2), 402-407.
https://doi.org/10.1016/j.atherosclerosis.2015.04.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27876
Lawrence, M., Sabra, A., Mills, G., Pillai, S., Abdullah, W., Hawkins, K., Morris, R., Davidson, S., D´Silva, L., Curtis, D., Brown, R., Weisel, J., Williams, R., & Evans, A. (2015). A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism. British Journal of Haematology, 168(4), 571-575.
https://doi.org/10.1111/bjh.13173, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27555
Chan, C., Pieper, I., Fleming, S., Friedmann, Y., Foster, G., Hawkins, K., Thornton, C., & Kanamarlapudi, V. (2014). The Effect of Shear Stress on the Size, Structure, and Function of Human von Willebrand Factor. Artificial Organs, 38(9), 741-750.
https://doi.org/10.1111/aor.12382, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18740
Lawrence, M., Kumar, S., Hawkins, K., Boden, S., Rutt, H., Mills, G., Sabra, A., Morris, R., Davidson, S., Badiei, N., Brown, M., Williams, P., Evans, P., Williams, R., Brown, R., & Evans, A. (2014). A new structural biomarker that quantifies and predicts changes in clot strength and quality in a model of progressive haemodilution. Thrombosis Research, 134(2), 488-494.
https://doi.org/10.1016/j.thromres.2014.05.039, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18269
Stanford, S., Sabra, A., Lawrence, M., Morris, R., Storton, S., Wani, M., Hawkins, K., Williams, P., Potter, J., Evans, P., Williams, R., & Evans, A. (2014). Prospective Evaluation of Blood Coagulability and Effect of Treatment in Patients with Stroke Using Rotational Thromboelastometry. Journal of Stroke and Cerebrovascular Diseases
https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.08.028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19733
Ramadan, Y., González-Sánchez, M., Hawkins, K., Rubio-Retama, J., Valero, E., Perni, S., Prokopovich, P., & López-Cabarcos, E. (2014). Obtaining new composite biomaterials by means of mineralization of methacrylate hydrogels using the reaction–diffusion method. Materials Science and Engineering: C, 42, 696-704.
https://doi.org/10.1016/j.msec.2014.06.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18267
Davies, G., Mills, G., Lawrence, M., Battle, C., Morris, K., Hawkins, K., Williams, R., Davidson, S., Thomas, D., & Evans, A. (2014). The Role of Whole Blood Impedance Aggregometry and Its Utilisation in the Diagnosis and Prognosis of Patients with Systemic Inflammatory Response Syndrome and Sepsis in Acute Critical Illness. PLoS ONE, 9(9), e108589
https://doi.org/10.1371/journal.pone.0108589, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa21117
Chan, C., Hilton, A., Foster, G., Hawkins, K., Badiei, N., & Thornton, C. (2013). The Evaluation of Leukocytes in Response to the In Vitro Testing of Ventricular Assist Devices. Artificial Organs, n/a-n/a.
https://doi.org/10.1111/aor.12161, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15872
Curtis, D., Williams, P., Badiei, N., Campbell, A., Hawkins, K., Evans, P., Brown, M., Williams, R., Brown, R., & Evans, A. (2013). A study of microstructural templating in fibrin-thrombin gel networks by spectral and viscoelastic analysis. Soft Matter, 9(19), 4883-4889.
https://doi.org/10.1039/C3SM50263E, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14405
Powell, L., Powell, L., Sowedan, A., Khan, S., Wright, C., Hawkins, K., Onsøyen, E., Myrvold, R., Hill, K., Thomas, D., & Wright, C. (2013). The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms. Biofouling, 29(4), 413-421.
https://doi.org/10.1080/08927014.2013.777954, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14404
Chan, C., Hilton, A., Foster, G., & Hawkins, K. (2012). Reevaluation of the Harboe Assay as a Standardized Method of Assessment for the Hemolytic Performance of Ventricular Assist Devices. Artificial Organs, 36(8), 724-730.
https://doi.org/10.1111/j.1525-1594.2012.01515.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15555
Liu, Y., Servant, A., Guy, O., Al-Jamal, K., Williams, P., Hawkins, K., Kostarelos, K., Williams, R., Guy, O., Hawkins, K., & Liu, Y. (2012). An electric-field responsive microsystem for controllable miniaturised drug delivery applications. Sensors and Actuators B: Chemical, 175, 100-105.
https://doi.org/10.1016/j.snb.2011.12.069, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10969
Hawkins, K. (2012). Re-Evaluation of the Harboe Assay as a Standardised Method of Assessment for the Haemolytic Performance of VADs. Artificial Organs
https://doi.org/10.1111/j.1525-1594.2012.01515.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10643
Brown, M., Curtis, D., Rees, P., Summers, H., Hawkins, K., Evans, P., Williams, P., Williams, R., Hawkins, K., Brown, R., Rees, P., Summers, H., Curtis, D., & Evans, A. (2012). Fractal discrimination of random fractal aggregates and its application in biomarker analysis for blood coagulation. Chaos, Solitons & Fractals, 45(8), 1025-1032.
https://doi.org/10.1016/j.chaos.2012.04.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10968
Curtis, D., Brown, M., Hawkins, K., Evans, P., Lawrence, M., Rees, P., Williams, P., Williams, R., Hawkins, K., Brown, R., Rees, P., Lawrence, M., Curtis, D., & Evans, A. (2011). Rheometrical and molecular dynamics simulation studies of incipient clot formation in fibrin-thrombin gels: An activation limited aggregation approach. Journal of Non-Newtonian Fluid Mechanics, 166(16), 932-938.
https://doi.org/10.1016/j.jnnfm.2011.04.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12137
Curtis, D., Hawkins, K., Lawrence, M., Davies, T., Brown, M., Williams, P., & Hawkins, K. (2010). Incipient fibrin gel microstructure as an indication of maturing clot growth processes. Journal Series on Biomechanics, 25, 184-189.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20282
Hawkins, K., Evans, P., Lawrence, M., Curtis, D., Davies, M., Williams, P., Williams, R., & Evans, A. (2010). The development of rheometry for strain-sensitive gelling systems and its application in a study of fibrin–thrombin gel formation. Rheologica Acta, 49(9), 891-900.
https://doi.org/10.1007/s00397-010-0473-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10210
Evans, P., Lawrence, M., Morris, R., Thirumalai, N., Munro, R., Wakeman, L., Beddel, A., Williams, P., Barrow, M., Curtis, D., Brown, M., Hawkins, K., Williams, R., Brown, R., & Evans, A. (2010). Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation. Rheologica Acta, 49(9), 901-908.
https://doi.org/10.1007/s00397-010-0472-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10212
Evans, A., Hawkins, K., Morris, R., Thirumalai, N., Munro, R., Wakeman, L., Lawrence, M., & Williams, R. (2010). Gel point and fractal microstructure of incipient blood clots are significant new markers of hemostasis for healthy and anticoagulated blood. Blood, 116(17), 3341-3346.
https://doi.org/10.1182/blood-2010-02-269324, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9876
Evans, P., Hawkins, K., Lawrence, M., Barrow, M., Williams, P., Williams, R., Hawkins, K., & Lawrence, M. (2008). Studies of whole blood coagulation by oscillatory shear, thromboelastography and free oscillation rheometry. Clinical Hemorheology and Microcirculation, 38
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27886
http://www.scopus.com/inward/record.url?eid=2-s2.0-42049090153&partnerID=MN8TOARS
Evans, P., Hawkins, K., Lawrence, M., Williams, P., Williams, R., Hawkins, K., Lawrence, M., & Evans, A. (2008). Rheometrical studies of blood clot formation by oscillatory shear, thromboelastography, sonoclot analysis and free oscillation rheometry. In AIP Conference Proceedings
https://doi.org/10.1063/1.2964777, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27888
http://www.scopus.com/inward/record.url?eid=2-s2.0-51149108508&partnerID=MN8TOARS
Hawkins, K., Lawrence, M., Williams, P., Williams, R., Hawkins, K., & Lawrence, M. (2008). A study of gelatin gelation by Fourier transform mechanical spectroscopy. Journal of Non-Newtonian Fluid Mechanics, 148(1-3), 127-133.
https://doi.org/10.1016/j.jnnfm.2007.05.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9877
Evans, P., Hawkins, K., Lawrence, M., Williams, R., Barrow, M., Thirumalai, N., Williams, P., Barrow, M., Hawkins, K., Lawrence, M., & Evans, A. (2008). Rheometry and associated techniques for blood coagulation studies. Medical Engineering & Physics, 30(6), 671-679.
https://doi.org/10.1016/j.medengphy.2007.08.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10211
Evans, A., Hawkins, K., Williams, R., & Williams, R. (2008). Rheometrical detection of incipient blood clot formation by Fourier transform mechanical spectroscopy. Journal of Non-Newtonian Fluid Mechanics, 148(1-3), 122-126.
https://doi.org/10.1016/j.jnnfm.2007.04.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1806
Hawkins, K. (2006). Rheometrical and computational studies of blood viscoelasticity during coagulation. Clinical Haemorheology and Microcirculation, 31(1-2), 123-127.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20609
Jones, R., Ravji, S., Hawkins, K., Al-Hussany, A., Williams, P., Williams, R., Williams, R., & Hawkins, K. (2004). An assessment of dispersion-induced errors in shear wave propagation measurements in critical gel and pre-gel point fluids. , 11-24.
https://doi.org/10.1016/j.jnnfm.2004.07.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1804
Hawkins, K. (2003). High deformation rate uniaxial elongational flow of mobile fluids in cavitation bubble collapse experiments.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45936
Cordy, S., Barrow, M., Brown, S., Hawkins, K., Williams, P., & Hawkins, K. (2003). Rheology of multigrade engine lubricants in high deformation rate extensional flow.
https://doi.org/10.4271/2003-01-3121, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45937
Gopala Pillai, S., Butcher, L., Carnicero, J., Hawkins, K., Whitley, J., Mothukuri, R., Morris, K., Erusalimsky, J., & Evans, A. (2023). The biomarkers sRAGE and df in combination are significant predictors of mortality in COVID‑19 patients. Critical Care, 27(S1), P137
https://doi.org/10.1186/s13054-023-04377-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65237
Gopala Pillai, S., Zaldua, J., Watson, O., Howard, M., Lawrence, M., Whitley, J., Hawkins, K., Morris, K., & Evans, A. (2023). Low FEV1 is associated with increased mortality in acute exacerbation of COPD (AECOPD) in one year. Critical Care, 27(S1)
https://doi.org/10.1186/s13054-023-04377-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65238
Gopala Pillai, S., Watson, O., Howard, M., Whitley, J., Hawkins, K., Morris, K., & Evans, A. (2023). Does clot microstructure (df) predict mortality in acute exacerbation of chronic obstructive pulmonary disease (AECOPD)?. Critical Care, 27(S1), 107-108.
https://doi.org/10.1186/s13054-023-04377-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65239
Howard, M., Watson, O., Zaldua, J., Gopala Pillai, S., Whitley, J., Lawrence, M., Hawkins, K., Guy, O., & Evans, A. (2022). NEWS2 predicts severity of underlying inflammatory response and outcome in COVID-19 patients. In Critical Care (pp. 25-26). Springer Science and Business Media LLC.
https://doi.org/10.1186/s13054-022-03927-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65240
http://dx.doi.org/10.1186/s13054-022-03927-z
Gopala Pillai, S., Zaldua, J., Whitley, J., Watson, O., Howard, M., Hawkins, K., Morris, K., & Evans, A. (2022). The relationship between the procalcitonin levels and clot microstructure in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Critical Care, 26(S1), 26-26.
https://doi.org/10.1186/s13054-022-03927-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65241
Gopala Pillai, S., Zaldua, J., Lawrence, M., Whitley, J., Watson, O., Harrison, K., Hawkins, K., Morris, K., & Evans, A. (2022). Clot microstructure (df) as a biomarker and measurement of thrombogenicity in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Critical Care, 26(S1), 28-28.
https://doi.org/10.1186/s13054-022-03927-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65242
Watson, O., Howard, M., Zaldua, J., Whitley, J., Gopala Pillai, S., Lawrence, M., Burgess, B., Hawkins, K., Morris, K., & Evans, A. (2022). Impaired fibrinolysis is implicated in mortality in COVID‑19 infection. In Critical Care (pp. 31-31). Springer Science and Business Media LLC.
https://doi.org/10.1186/s13054-022-03927-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65244
http://dx.doi.org/10.1186/s13054-022-03927-z
Moura, J., Barlow, H., Doak, S., Hawkins, K., Muller, I., & Clift, M. (2024). Exploring the Role of Fibrin Gels in Enhancing Cell Migration for Vasculature Formation. Journal of Functional Biomaterials, 15(9), 265
https://doi.org/10.3390/jfb15090265, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67608

All Research

Journal Articles

Moura, J., Barlow, H., Doak, S., Hawkins, K., Muller, I., & Clift, M. (2024). Exploring the Role of Fibrin Gels in Enhancing Cell Migration for Vasculature Formation. Journal of Functional Biomaterials, 15(9), 265
https://doi.org/10.3390/jfb15090265, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67608
Watson, O., ZALDUA, J., Gopala Pillai, S., Whitley, J., Howard, M., Lawrence, M., Hawkins, K., Morris, K., & Evans, A. (2023). The efficacy of low molecular weight heparin is reduced in Covid-19. Clinical Hemorheology and Microcirculation, 84(3), 1-12.
https://doi.org/10.3233/ch-221635, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63235
http://dx.doi.org/10.3233/ch-221635
Gopala Pillai, S., Butcher, L., Carnicero, J., Hawkins, K., Whitley, J., Mothukuri, R., Morris, K., Erusalimsky, J., & Evans, A. (2023). The biomarkers sRAGE and df in combination are significant predictors of mortality in COVID‑19 patients. Critical Care, 27(S1), P137
https://doi.org/10.1186/s13054-023-04377-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65237
Gopala Pillai, S., Zaldua, J., Watson, O., Howard, M., Lawrence, M., Whitley, J., Hawkins, K., Morris, K., & Evans, A. (2023). Low FEV1 is associated with increased mortality in acute exacerbation of COPD (AECOPD) in one year. Critical Care, 27(S1)
https://doi.org/10.1186/s13054-023-04377-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65238
Gopala Pillai, S., Watson, O., Howard, M., Whitley, J., Hawkins, K., Morris, K., & Evans, A. (2023). Does clot microstructure (df) predict mortality in acute exacerbation of chronic obstructive pulmonary disease (AECOPD)?. Critical Care, 27(S1), 107-108.
https://doi.org/10.1186/s13054-023-04377-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65239
Lawrence, M., Obaid, D., Sabra, A., Whitley, J., Whitley, J., Quarry, R., Gopala Pillai, S., Chase, A., Smith, D., Williams, R., Hawkins, K., Morris, R., & Evans, A. (2023). The Impact of Patient Characteristics and Antiplatelet Regimes on Clot Microstructure in Patients Treated for ST Elevation Myocardial Infarction: Clot Microstructure can Evaluate Therapeutic Efficacy. Clinical and Applied Thrombosis/Hemostasis, 29, 107602962211315
https://doi.org/10.1177/10760296221131563, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63236
http://dx.doi.org/10.1177/10760296221131563
Watson, O., Gopala Pillai, S., Howard, M., Zaldua, J., Whitley, J., Burgess, B., Lawrence, M., Hawkins, K., Morris, K., & Evans, A. (2022). Impaired fibrinolysis in severe Covid-19 infection is detectable in early stages of the disease. Clinical Hemorheology and Microcirculation, 82(2), 183-191.
https://doi.org/10.3233/ch-221491, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61002
https://pubmed.ncbi.nlm.nih.gov/35694917/
Butcher, L., Zaldua, J., Carnicero, J., Hawkins, K., Whitley, J., Mothukuri, R., Evans, A., Morris, K., Pillai, S., & Erusalimsky, J. (2022). High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone. Respiratory Research, 23(1)
https://doi.org/10.1186/s12931-022-02220-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62071
Gopala Pillai, S., Zaldua, J., Whitley, J., Watson, O., Howard, M., Hawkins, K., Morris, K., & Evans, A. (2022). The relationship between the procalcitonin levels and clot microstructure in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Critical Care, 26(S1), 26-26.
https://doi.org/10.1186/s13054-022-03927-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65241
Gopala Pillai, S., Zaldua, J., Lawrence, M., Whitley, J., Watson, O., Harrison, K., Hawkins, K., Morris, K., & Evans, A. (2022). Clot microstructure (df) as a biomarker and measurement of thrombogenicity in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Critical Care, 26(S1), 28-28.
https://doi.org/10.1186/s13054-022-03927-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65242
Evans, V., Lawrence, M., Whitley, J., Johns, C., Gopala Pillai, S., Hawkins, K., Power, K., Morris, K., Williams, R., & Evans, A. (2022). The treatment effect of rivaroxaban on clot characteristics in patients who present acutely with first time deep vein thrombosis. Clinical Hemorheology and Microcirculation, 80(2), 139-151.
https://doi.org/10.3233/ch-201030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56606
Tarassoli, S., Jessop, Z., Jovic, T., Hawkins, K., & Whitaker, I. (2021). Candidate Bioinks for Extrusion 3D Bioprinting—A Systematic Review of the Literature. Frontiers in Bioengineering and Biotechnology, 9
https://doi.org/10.3389/fbioe.2021.616753, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56759
Thomas, B., Hambly, R., Weisel, J., Rauova, L., Badiei, N., Brown, R., Thornton, C., Williams, R., & Hawkins, K. (2020). Abnormal clot microstructure formed in blood containing HIT-like antibodies. Thrombosis Research, 193, 25-30.
https://doi.org/10.1016/j.thromres.2020.05.029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54403
Hawkins, K. & Curtis, D. (2020). Papers from the 2019 Institute of Non-Newtonian Fluid Mechanics Meeting in Lake Vyrnwy, Wales. Physics of Fluids, 32(4), 040401
https://doi.org/10.1063/5.0008256, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54103
Sabra, A., Lawrence, M., Curtis, D., Hawkins, K., Williams, R., & Evans, A. (2020). In vitro clot model to evaluate fibrin-thrombin effects on fractal dimension of incipient blood clot. Clinical Hemorheology and Microcirculation, 74(2), 147-153.
https://doi.org/10.3233/ch-190615, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51304
Jessop, Z., Al-Sabah, A., Gao, N., Kyle, S., Thomas, B., Badiei, N., Hawkins, K., & Whitaker, I. (2019). Printability of pulp derived crystal, fibril and blend nanocellulose-alginate bioinks for extrusion 3D bioprinting. Biofabrication, 11(4), 045006
https://doi.org/10.1088/1758-5090/ab0631, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51247
Kyle, S., Jessop, Z., Al-Sabah, A., Hawkins, K., Lewis, A., Maffeis, T., Charbonneau, C., Gazze, A., Francis, L., Iakovlev, M., Nelson, K., Eichhorn, S., & Whitaker, I. (2018). Characterization of pulp derived nanocellulose hydrogels using AVAP® technology. Carbohydrate Polymers, 198, 270-280.
https://doi.org/10.1016/j.carbpol.2018.06.091, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40840
Holder, A., Badiei, N., Hawkins, K., Wright, C., Williams, R., & Curtis, D. (2018). Control of collagen gel mechanical properties through manipulation of gelation conditions near the sol–gel transition. Soft Matter, 14, 574-580.
https://doi.org/10.1039/C7SM01933E, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36407
Radley, G., Pieper, I., Thomas, B., Hawkins, K., & Thornton, C. (2018). Artificial Shear Stress Effects on Leukocytes at a Biomaterial Interface. Artificial Organs
https://doi.org/10.1111/aor.13409, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49111
Lamer, T., Thomas, B., Curtis, D., Badiei, N., Williams, P., Hawkins, K., Williams, R., Hawkins, K., & Curtis, D. (2017). The application of large amplitude oscillatory stress in a study of fully formed fibrin clots. Physics of Fluids, 29(12), 121606
https://doi.org/10.1063/1.4999991, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35309
Hudson, R., Holder, A., Hawkins, K., Curtis, D., & Williams, R. (2017). An enhanced rheometer inertia correction procedure (ERIC) for the study of gelling systems using combined motor-transducer rheometers. Physics of Fluids, 29(12)
https://doi.org/10.1063/1.4993308, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35940
Hawkins, K. (2017). Preface to Special Topic: Papers from the Institute of Non-Newtonian Fluid Mechanics Meeting, Lake Vyrnwy, 2017. Physics of Fluids, 29(12), 121401
https://doi.org/10.1063/1.5018585, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38182
Jessop, Z., Al-Sabah, A., Gardiner, M., Combellack, E., Hawkins, K., & Whitaker, I. (2017). “3D Bioprinting for Reconstructive Surgery: Principles, Applications and Challenges”. Journal of Plastic, Reconstructive & Aesthetic Surgery
https://doi.org/10.1016/j.bjps.2017.06.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34593
Knowles, R., Lawrence, M., Ferreira, P., Hayman, M., D’Silva, L., Stanford, S., Sabra, A., Tucker, A., Hawkins, K., Williams, P., Warner, T., Evans, P., & Williams, R. (2017). Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties. Platelets, 1-9.
https://doi.org/10.1080/09537104.2017.1306039, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33740
Sabra, A., Lawrence, M., Aubrey, R., Obaid, D., Chase, A., Smith, D., Thomas, P., Storton, S., Davies, G., Hawkins, K., Williams, P., Morris, K., & Evans, A. (2017). Characterisation of clot microstructure properties in stable coronary artery disease. Open Heart, 4(2), e000562
https://doi.org/10.1136/openhrt-2016-000562, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37018
Burke, L., Mortimer, C., Curtis, D., Lewis, A., Williams, R., Hawkins, K., Maffeis, T., Wright, C., & Wright, C. (2017). In-situ synthesis of magnetic iron-oxide nanoparticle-nanofibre composites using electrospinning. Materials Science and Engineering: C, 70, 512-519.
https://doi.org/10.1016/j.msec.2016.09.014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29839
D׳Silva, L., Wilczynska, M., Lewis, K., Lawrence, M., Hawkins, K., Williams, R., Stanford, S., Davidson, S., Morris, K., & Evans, A. (2016). Altered clot microstructure detected in obstructive sleep apnoea hypopnoea syndrome. Sleep Science, 9(1), 14-19.
https://doi.org/10.1016/j.slsci.2016.02.175, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29370
Lawrence, M., Marsden, N., Kaczynski, J., Davies, G., Davies, N., Hawkins, K., Perumal, S., Brown, M., Morris, K., Davidson, S., Williams, P., Evans, P., Brown, R., & Evans, A. (2016). An Investigation Into the Effects of In Vitro Dilution With Different Colloid Resuscitation Fluids on Clot Microstructure Formation. Anesthesia & Analgesia, 1
https://doi.org/10.1213/ANE.0000000000001536, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30371
Davies, N., Llwyd, O., Brugniaux, J., Davies, G., Marley, C., Hodson, D., Lawrence, M., D'Silva, L., Morris, R., Hawkins, K., Williams, R., Bailey, D., & Evans, A. (2016). Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals. Thrombosis Research, 143, 130-136.
https://doi.org/10.1016/j.thromres.2016.05.018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29486
Tassieri, M., Laurati, M., Curtis, D., Auhl, D., Coppola, S., Scalfati, A., Hawkins, K., Williams, R., & Cooper, J. (2016). i-Rheo: Measuring the materials' linear viscoelastic properties “in a step”!. Journal of Rheology, 60(4), 649-660.
https://doi.org/10.1122/1.4953443, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27484
Powell, L., Pritchard, M., Powell, L., Menzies, G., Lewis, P., Hawkins, K., Wright, C., Doull, I., Walsh, T., Onsøyen, E., Dessen, A., Myrvold, R., Rye, P., Myrset, A., Stevens, H., Hodges, L., MacGregor, G., Neilly, J., Hill, K...., & Wright, C. (2016). A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease. Molecular Pharmaceutics, 13(3), 863-872.
https://doi.org/10.1021/acs.molpharmaceut.5b00794, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26822
Lawrence, M., Marsden, N., Mothukuri, R., Morris, R., Davies, G., Hawkins, K., Curtis, D., Brown, M., Williams, P., Evans, P., Williams, R., Brown, R., & Evans, A. (2016). The Effects of Temperature on Clot Microstructure and Strength in Healthy Volunteers. Anesthesia & Analgesia, 122(1), 21-26.
https://doi.org/10.1213/ANE.0000000000000992, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27872
http://www.scopus.com/inward/record.url?eid=2-s2.0-84951567216&partnerID=MN8TOARS
Chan, C., Pieper, I., Hambly, R., Radley, G., Jones, A., Friedmann, Y., Hawkins, K., Westaby, S., Foster, G., & Thornton, C. (2015). The CentriMag Centrifugal Blood Pump as a Benchmark for In Vitro Testing of Hemocompatibility in Implantable Ventricular Assist Devices. Artificial Organs, 39(2), 93-101.
https://doi.org/10.1111/aor.12351, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18432
López-Aguilar, J., Webster, M., Al-Muslimawi, A., Tamaddon Jahromi, H., Williams, R., Hawkins, K., Askill, C., Ch’ng, C., Davies, G., Ebden, P., & Lewis, K. (2015). A computational extensional rheology study of two biofluid systems. Rheologica Acta, 54(4), 287-305.
https://doi.org/10.1007/s00397-014-0830-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29169
Broome, L., Davies, N., Harrison, N., Morris, R., Noble, S., Lawrence, M., D'Silva, L., Broome, L., Brown, R., Hawkins, K., Williams, R., Davidson, S., & Evans, A. (2015). Fractal dimension (df) as a new structural biomarker of clot microstructure in different stages of lung cancer. Thrombosis and Haemostasis, 114(6), 1251-1259.
https://doi.org/10.1160/TH15-04-0357, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22970
Davies, N., Harrison, N., Sabra, A., Lawrence, M., Noble, S., Davidson, S., Evans, V., Morris, R., Hawkins, K., Williams, P., Evans, P., Williams, R., Hawkins, K., Lawrence, M., Evans, A., & Davies, N. (2015). Application of ROTEM to assess hypercoagulability in patients with lung cancer. Thrombosis Research
https://doi.org/10.1016/j.thromres.2015.03.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20596
Stanford, S., Sabra, A., D’Silva, L., Lawrence, M., Morris, R., Storton, S., Brown, M., Evans, V., Hawkins, K., Williams, P., Davidson, S., Wani, M., Potter, J., Evans, P., Williams, R., Brown, R., & Evans, A. (2015). The changes in clot microstructure in patients with ischaemic stroke and the effects of therapeutic intervention: a prospective observational study. BMC Neurology, 15(1)
https://doi.org/10.1186/s12883-015-0289-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20524
González-Sánchez, M., Perni, S., Tommasi, G., Morris, N., Hawkins, K., López-Cabarcos, E., & Prokopovich, P. (2015). Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications. Materials Science and Engineering: C, 50, 332-340.
https://doi.org/10.1016/j.msec.2015.02.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20333
Badiei, N., Sowedan, A., Curtis, D., Brown, R., Lawrence, M., Campbell, A., Sabra, A., Evans, A., Weisel, J., Chernysh, I., Nagaswami, C., Williams, R., & Hawkins, K. (2015). Effects of unidirectional flow shear stresses on the formation, fractal microstructure and rigidity of incipient whole blood clots and fibrin gels. Clinical Hemorheology and Microcirculation, 60(4), 451-464.
https://doi.org/10.3233/ch-151924, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20275
Curtis, D., Holder, A., Badiei, N., Claypole, J., Walters, M., Thomas, B., Barrow, M., Deganello, D., Brown, R., Williams, R., & Hawkins, K. (2015). Validation of Optimal Fourier Rheometry for rapidly gelling materials and its application in the study of collagen gelation. Journal of Non-Newtonian Fluid Mechanics, 222, 253-259.
https://doi.org/10.1016/j.jnnfm.2015.01.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20273
http://dx.doi.org/10.1016/j.jnnfm.2015.01.003
Curtis, D., Badiei, N., Holder, A., Claypole, J., Deganello, D., Brown, R., Lawrence, M., Evans, A., Williams, R., & Hawkins, K. (2015). Assessment of the stress relaxation characteristics of critical gels formed under unidirectional shear flow by controlled stress parallel superposition rheometry. Journal of Non-Newtonian Fluid Mechanics, 222, 227-233.
https://doi.org/10.1016/j.jnnfm.2014.12.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20274
Lawrence, M., Sabra, A., Thomas, P., Obaid, D., D´Silva, L., Morris, R., Hawkins, K., Brown, R., Williams, R., Davidson, S., Chase, A., Smith, D., & Evans, A. (2015). Fractal dimension: A novel clot microstructure biomarker use in ST elevation myocardial infarction patients. Atherosclerosis, 240(2), 402-407.
https://doi.org/10.1016/j.atherosclerosis.2015.04.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27876
Lawrence, M., Sabra, A., Mills, G., Pillai, S., Abdullah, W., Hawkins, K., Morris, R., Davidson, S., D´Silva, L., Curtis, D., Brown, R., Weisel, J., Williams, R., & Evans, A. (2015). A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism. British Journal of Haematology, 168(4), 571-575.
https://doi.org/10.1111/bjh.13173, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27555
Chan, C., Pieper, I., Fleming, S., Friedmann, Y., Foster, G., Hawkins, K., Thornton, C., & Kanamarlapudi, V. (2014). The Effect of Shear Stress on the Size, Structure, and Function of Human von Willebrand Factor. Artificial Organs, 38(9), 741-750.
https://doi.org/10.1111/aor.12382, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18740
Lawrence, M., Kumar, S., Hawkins, K., Boden, S., Rutt, H., Mills, G., Sabra, A., Morris, R., Davidson, S., Badiei, N., Brown, M., Williams, P., Evans, P., Williams, R., Brown, R., & Evans, A. (2014). A new structural biomarker that quantifies and predicts changes in clot strength and quality in a model of progressive haemodilution. Thrombosis Research, 134(2), 488-494.
https://doi.org/10.1016/j.thromres.2014.05.039, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18269
Stanford, S., Sabra, A., Lawrence, M., Morris, R., Storton, S., Wani, M., Hawkins, K., Williams, P., Potter, J., Evans, P., Williams, R., & Evans, A. (2014). Prospective Evaluation of Blood Coagulability and Effect of Treatment in Patients with Stroke Using Rotational Thromboelastometry. Journal of Stroke and Cerebrovascular Diseases
https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.08.028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19733
Ramadan, Y., González-Sánchez, M., Hawkins, K., Rubio-Retama, J., Valero, E., Perni, S., Prokopovich, P., & López-Cabarcos, E. (2014). Obtaining new composite biomaterials by means of mineralization of methacrylate hydrogels using the reaction–diffusion method. Materials Science and Engineering: C, 42, 696-704.
https://doi.org/10.1016/j.msec.2014.06.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18267
Davies, G., Mills, G., Lawrence, M., Battle, C., Morris, K., Hawkins, K., Williams, R., Davidson, S., Thomas, D., & Evans, A. (2014). The Role of Whole Blood Impedance Aggregometry and Its Utilisation in the Diagnosis and Prognosis of Patients with Systemic Inflammatory Response Syndrome and Sepsis in Acute Critical Illness. PLoS ONE, 9(9), e108589
https://doi.org/10.1371/journal.pone.0108589, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa21117
Chan, C., Hilton, A., Foster, G., Hawkins, K., Badiei, N., & Thornton, C. (2013). The Evaluation of Leukocytes in Response to the In Vitro Testing of Ventricular Assist Devices. Artificial Organs, n/a-n/a.
https://doi.org/10.1111/aor.12161, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15872
Curtis, D., Williams, P., Badiei, N., Campbell, A., Hawkins, K., Evans, P., Brown, M., Williams, R., Brown, R., & Evans, A. (2013). A study of microstructural templating in fibrin-thrombin gel networks by spectral and viscoelastic analysis. Soft Matter, 9(19), 4883-4889.
https://doi.org/10.1039/C3SM50263E, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14405
Powell, L., Powell, L., Sowedan, A., Khan, S., Wright, C., Hawkins, K., Onsøyen, E., Myrvold, R., Hill, K., Thomas, D., & Wright, C. (2013). The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms. Biofouling, 29(4), 413-421.
https://doi.org/10.1080/08927014.2013.777954, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14404
Chan, C., Hilton, A., Foster, G., & Hawkins, K. (2012). Reevaluation of the Harboe Assay as a Standardized Method of Assessment for the Hemolytic Performance of Ventricular Assist Devices. Artificial Organs, 36(8), 724-730.
https://doi.org/10.1111/j.1525-1594.2012.01515.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15555
Liu, Y., Servant, A., Guy, O., Al-Jamal, K., Williams, P., Hawkins, K., Kostarelos, K., Williams, R., Guy, O., Hawkins, K., & Liu, Y. (2012). An electric-field responsive microsystem for controllable miniaturised drug delivery applications. Sensors and Actuators B: Chemical, 175, 100-105.
https://doi.org/10.1016/j.snb.2011.12.069, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10969
Hawkins, K. (2012). Re-Evaluation of the Harboe Assay as a Standardised Method of Assessment for the Haemolytic Performance of VADs. Artificial Organs
https://doi.org/10.1111/j.1525-1594.2012.01515.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10643
Brown, M., Curtis, D., Rees, P., Summers, H., Hawkins, K., Evans, P., Williams, P., Williams, R., Hawkins, K., Brown, R., Rees, P., Summers, H., Curtis, D., & Evans, A. (2012). Fractal discrimination of random fractal aggregates and its application in biomarker analysis for blood coagulation. Chaos, Solitons & Fractals, 45(8), 1025-1032.
https://doi.org/10.1016/j.chaos.2012.04.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10968
Curtis, D., Brown, M., Hawkins, K., Evans, P., Lawrence, M., Rees, P., Williams, P., Williams, R., Hawkins, K., Brown, R., Rees, P., Lawrence, M., Curtis, D., & Evans, A. (2011). Rheometrical and molecular dynamics simulation studies of incipient clot formation in fibrin-thrombin gels: An activation limited aggregation approach. Journal of Non-Newtonian Fluid Mechanics, 166(16), 932-938.
https://doi.org/10.1016/j.jnnfm.2011.04.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12137
Curtis, D., Hawkins, K., Lawrence, M., Davies, T., Brown, M., Williams, P., & Hawkins, K. (2010). Incipient fibrin gel microstructure as an indication of maturing clot growth processes. Journal Series on Biomechanics, 25, 184-189.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20282
Hawkins, K., Evans, P., Lawrence, M., Curtis, D., Davies, M., Williams, P., Williams, R., & Evans, A. (2010). The development of rheometry for strain-sensitive gelling systems and its application in a study of fibrin–thrombin gel formation. Rheologica Acta, 49(9), 891-900.
https://doi.org/10.1007/s00397-010-0473-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10210
Evans, P., Lawrence, M., Morris, R., Thirumalai, N., Munro, R., Wakeman, L., Beddel, A., Williams, P., Barrow, M., Curtis, D., Brown, M., Hawkins, K., Williams, R., Brown, R., & Evans, A. (2010). Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation. Rheologica Acta, 49(9), 901-908.
https://doi.org/10.1007/s00397-010-0472-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10212
Evans, A., Hawkins, K., Morris, R., Thirumalai, N., Munro, R., Wakeman, L., Lawrence, M., & Williams, R. (2010). Gel point and fractal microstructure of incipient blood clots are significant new markers of hemostasis for healthy and anticoagulated blood. Blood, 116(17), 3341-3346.
https://doi.org/10.1182/blood-2010-02-269324, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9876
Evans, P., Hawkins, K., Lawrence, M., Barrow, M., Williams, P., Williams, R., Hawkins, K., & Lawrence, M. (2008). Studies of whole blood coagulation by oscillatory shear, thromboelastography and free oscillation rheometry. Clinical Hemorheology and Microcirculation, 38
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27886
http://www.scopus.com/inward/record.url?eid=2-s2.0-42049090153&partnerID=MN8TOARS
Hawkins, K., Lawrence, M., Williams, P., Williams, R., Hawkins, K., & Lawrence, M. (2008). A study of gelatin gelation by Fourier transform mechanical spectroscopy. Journal of Non-Newtonian Fluid Mechanics, 148(1-3), 127-133.
https://doi.org/10.1016/j.jnnfm.2007.05.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9877
Evans, P., Hawkins, K., Lawrence, M., Williams, R., Barrow, M., Thirumalai, N., Williams, P., Barrow, M., Hawkins, K., Lawrence, M., & Evans, A. (2008). Rheometry and associated techniques for blood coagulation studies. Medical Engineering & Physics, 30(6), 671-679.
https://doi.org/10.1016/j.medengphy.2007.08.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10211
Evans, A., Hawkins, K., Williams, R., & Williams, R. (2008). Rheometrical detection of incipient blood clot formation by Fourier transform mechanical spectroscopy. Journal of Non-Newtonian Fluid Mechanics, 148(1-3), 122-126.
https://doi.org/10.1016/j.jnnfm.2007.04.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1806
Hawkins, K. (2006). Rheometrical and computational studies of blood viscoelasticity during coagulation. Clinical Haemorheology and Microcirculation, 31(1-2), 123-127.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20609
Jones, R., Ravji, S., Hawkins, K., Al-Hussany, A., Williams, P., Williams, R., Williams, R., & Hawkins, K. (2004). An assessment of dispersion-induced errors in shear wave propagation measurements in critical gel and pre-gel point fluids. , 11-24.
https://doi.org/10.1016/j.jnnfm.2004.07.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1804
Cordy, S., Barrow, M., Brown, S., Hawkins, K., Williams, P., & Hawkins, K. (2003). Rheology of multigrade engine lubricants in high deformation rate extensional flow.
https://doi.org/10.4271/2003-01-3121, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45937

Conference Contributions

Howard, M., Watson, O., Zaldua, J., Gopala Pillai, S., Whitley, J., Lawrence, M., Hawkins, K., Guy, O., & Evans, A. (2022). NEWS2 predicts severity of underlying inflammatory response and outcome in COVID-19 patients. In Critical Care (pp. 25-26). Springer Science and Business Media LLC.
https://doi.org/10.1186/s13054-022-03927-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65240
http://dx.doi.org/10.1186/s13054-022-03927-z
Watson, O., Howard, M., Zaldua, J., Whitley, J., Gopala Pillai, S., Lawrence, M., Burgess, B., Hawkins, K., Morris, K., & Evans, A. (2022). Impaired fibrinolysis is implicated in mortality in COVID‑19 infection. In Critical Care (pp. 31-31). Springer Science and Business Media LLC.
https://doi.org/10.1186/s13054-022-03927-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65244
http://dx.doi.org/10.1186/s13054-022-03927-z
Evans, P., Hawkins, K., Lawrence, M., Williams, P., Williams, R., Hawkins, K., Lawrence, M., & Evans, A. (2008). Rheometrical studies of blood clot formation by oscillatory shear, thromboelastography, sonoclot analysis and free oscillation rheometry. In AIP Conference Proceedings
https://doi.org/10.1063/1.2964777, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa27888
http://www.scopus.com/inward/record.url?eid=2-s2.0-51149108508&partnerID=MN8TOARS
Hawkins, K. (2003). High deformation rate uniaxial elongational flow of mobile fluids in cavitation bubble collapse experiments.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45936

Supervision

Optical based approaches for the rheological characterisation of blood (current)

PhD

Other supervisor: Dr Daniel Curtis
Rheological characterisation of blood components and the effects of lipopolysaccharide induced inflammation (current)

PhD

Other supervisor: Prof Thomas Wilkinson
Molecular Analysis of the Role of Shear and Glycosylation in von Willebrand Factor Degradation by ADAMTS13 (awarded 2024)

PhD

Other supervisor: Prof Venkat Kanamarlapudi
Development of Rheometry for the Characterisation of Rapidly Gelling Strain Sensitive Materials (awarded 2024)

PhD

Other supervisor: Dr Daniel Curtis
Clot microstructure (df) as a biomarker and measurement of thrombogenicity in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) (awarded 2024)

PhD

Other supervisor: Mr Kevin Harrison

Other supervisor: Prof Adrian Evans
Effects of COPD and its underlying inflammatory response on coagulation, and the effects of treatments including oxygen therapy and non-invasive ventilation as assessed by the biomarkers, fractal dimension and normal force- a feasibility study. (current)

MSc

Other supervisor: Prof Owen Guy
The effect of endurance exercise in middle-aged runners; are they thrombogenic? (current)

MSc

Other supervisor: Prof Adrian Evans
Analysis of existing and novel rheological biomarkers in acute ischaemic and haemorrhagic stroke (current)

MSc

Other supervisor: Prof Owen Guy

Taught Modules

PM-230 Selected Medical Diagnostic Techniques

This module looks at the design and operation of a wide range of instrumentation used to make measurements for diagnostic and monitoring of health and disease. The emphasis is on the underlying electrical, mechanical, chemical, optical and other engineering principles together with the advantages and limitations of techniques.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PMCB01 Clinical Biochemistry - Metabolism and Nutrition

This module will explore the key clinical biochemical principles that are relevant to the application of the principles of clinical biochemistry to evaluate the function of the various physiological systems, the biochemistry of the processes involved that support life; from the cellular to whole physiological systems and explore how clinical biochemistry can detect pathological dysfunction. It will critically develop your understanding of the various biochemical processes involved in the analytical detection of function and dysfunction within health and disease states across the life span.
PMNM02 Diagnostics and Imaging

Nanotechnology may lead to more rapid diagnostic tests, implantable devices, point of care instruments and improved medical imaging. This module will explore the application of nanotechnology to various medical techniques, focussing on novel research devices, pre-clinical tools and emerging technology within hospitals.
PMRM04 Dissertation (Research)

This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study.
PMZM13 Diagnostics and Imaging

Nanotechnology may lead to more rapid diagnostic tests, implantable devices, point of care instruments and improved medical imaging. This module will explore the application of nanotechnology to various medical techniques, focussing on novel research devices, pre-clinical tools and emerging technology within hospitals.

Key Grants and Projects

MRC - Confidence in Concept 2021

, £149K
Sêr Cymru – Tackling COVID-19 2020

, £100K
EPSRC Engineering Blood Diagnostics: Integrated Platforms for Advanced Detection and Analysis 2016 - 2021

, £1m
EPSRC Healthcare Impact Partnership for new blood clotting diagnostics and management 2014 - 2017

, £923k
NISCHR Haemostasis Biomedical Research Unit 2011 - 2015

, £1.5m
EPSRC First Grant Award (“Good clot? Bad clot?”) 2011 - 2013

, £102k
EPSRC Novel Technologies for Stem Cell Science 2010 - 2014

, £1.55m
EPSRC Grand Challenge in Nanotechnology for Healthcare 2009 - 2012

, £906k

Career History

Professor , Swansea University Medical School

2019 - Present
Associate Professor, Swansea University Medical School

2013 - 2019
Senior Lecturer , Swansea University Medical School

2011 - 2013
RCUK Fellow in Nanomedicine , Swansea University Medical School

2007 - 2012
British Council Visiting Researcher , Penn Medicine, USA

2007 - Present
EPSRC Researcher Co-Investigator, Faculty of Science and engineering

2005 - 2007

Other Roles

Honorary Secretary, British Society of Rheology

2016 - 2020
Director, Institute of Non-Newtonian Fluid Mechanics

2019 - Present
EPSRC Associate College Member, EPSRC

2016 - Present

Professor Karl Hawkins

Telephone number

Email address

Twitter Account

Research Links

About

Areas Of Expertise

Research Highlights

All Research

Optical based approaches for the rheological characterisation of blood (current)

Rheological characterisation of blood components and the effects of lipopolysaccharide induced inflammation (current)

Molecular Analysis of the Role of Shear and Glycosylation in von Willebrand Factor Degradation by ADAMTS13 (awarded 2024)

Development of Rheometry for the Characterisation of Rapidly Gelling Strain Sensitive Materials (awarded 2024)

Clot microstructure (df) as a biomarker and measurement of thrombogenicity in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) (awarded 2024)

Effects of COPD and its underlying inflammatory response on coagulation, and the effects of treatments including oxygen therapy and non-invasive ventilation as assessed by the biomarkers, fractal dimension and normal force- a feasibility study. (current)

The effect of endurance exercise in middle-aged runners; are they thrombogenic? (current)

Analysis of existing and novel rheological biomarkers in acute ischaemic and haemorrhagic stroke (current)

PM-230 Selected Medical Diagnostic Techniques

PM-344 Capstone Project

PMCB01 Clinical Biochemistry - Metabolism and Nutrition

PMNM02 Diagnostics and Imaging

PMRM04 Dissertation (Research)

PMZM13 Diagnostics and Imaging

MRC - Confidence in Concept 2021

Sêr Cymru – Tackling COVID-19 2020

NISCHR Haemostasis Biomedical Research Unit 2011 - 2015

Professor , Swansea University Medical School

Associate Professor, Swansea University Medical School

Senior Lecturer , Swansea University Medical School

RCUK Fellow in Nanomedicine , Swansea University Medical School

British Council Visiting Researcher , Penn Medicine, USA

EPSRC Researcher Co-Investigator, Faculty of Science and engineering

Honorary Secretary, British Society of Rheology

Director, Institute of Non-Newtonian Fluid Mechanics

EPSRC Associate College Member, EPSRC