DNA Damage and the Safety of Nanomaterials

We are developing tailored safety testing methods for nanomaterials

The Challenge

How do we assess the safety of nanomaterials? DNA damage in particular is a concern as it can lead to cancer development and so, assessing the DNA damaging capacity of a substance we are exposed to is a vital aspect of safety assessment. Although regulatory safety tests for chemicals are well defined, they are not always appropriate for nanomaterials. This has been a substantial barrier to nanotechnology innovation worldwide.

The Method

Professor Shareen Doak and her team have been developing tailored safety testing methods for nanomaterials and new, advanced non-animal tissue models. These improved safety testing tools are now being utilised in international nano-regulatory frameworks.

The Impact

The research conducted by Swansea University’s In Vitro Toxicology Group has been pivotal in developing standardised safety tests to facilitate nanomaterial risk assessment for human health.
Our research has been utilized in numerous international regulatory risk assessment policy documents world-wide to adapt the DNA damage testing methodology so that it is appropriate for evaluating nanomaterials, including: the Organisation for Economic Co-operation and Development (OECD), European Chemicals Agency (ECHA), European Food Safety Authority (EFSA), US-Canada Regulatory Co-Operation Council (RCC), US Environmental Protection Agency (EPA) and Australian Pesticides & Veterinary Medicines Authority.
The Horizon 2020 project PATROLS, coordinated by Swansea University has delivered several new scientific developments that have been recognised as ‘Excellent Innovation’ by the European Commission’s Innovation Radar. Those specifically developed by Swansea University include:
- “Human 3D Liver HepG2 Spheroids for Nanomaterial Genotoxicity and Hazard Assessment”
- “Human Calu-3 Bronchial Epithelial Cells Cultured at the Air-Liquid Interface for Aazard Assessment of Engineered Nanomaterials” – jointly developed between Swansea University and PATROLS partners from the Netherland and Switzerland

What our partners say

Research teams from the National Institute of Biology (NIB), Slovenia, and Swansea University, United Kingdom, have collaborated on an informal basis to foster the implementation of research and to go beyond the state of the art. A window of opportunity was the call for twinning and now the Twinning for excellence to strategically advance research in carcinogenesis and cancer (CutCancer) project provides an opportunity to formalise it. Opportunities for formal collaboration among research teams are scarce, so the importance of this collaboration is of vital importance for future collaborations. We envision not only the exchange of collaborators and students, but also the transfer of knowledge and the acceleration effect of cooperation between teams. Within CutCancer, the collaboration will enable the implementation of cutting-edge approaches and methods in the field of 3D cancer research. This will be done through the transfer of knowledge, exchange of best practises and the training opportunities for scientists. In addition, the collaboration will strengthen the research management capacity and administrative capabilities, including the Office of Technology Transfer, the Public Relations Office, the Library, and the Human Resources Office. Overall, the collaboration will significantly enhance the excellence of NIB at the regional level and internationally. Nonetheless, the project will promote excellence of both institutions. Prof. Dr. Bojana Žegur, National Institute of Biology