Institute of Life Science 1 internal Atrium view up

Professor Cathy Thornton

Personal Chair

Biomedical Sciences

+44 (0) 1792 602122

c.a.thornton@swansea.ac.uk

Office - 226
Second Floor
Institute of Life Science 1
Singleton Campus

Available For Postgraduate Supervision

Research Links

https://orcid.org/0000-0002-5153-573X

ResearchGate

About

Cathy Thornton is Professor of Human Immunology studying immunological adaptation in pregnancy and antenatal determinants of immune health in childhood. This includes study of the placenta in health and in adverse obstetric conditions. Interests in these areas also supports global challenges research related to improving maternal and neonatal health outcomes. Analysis of blood via various techniques is a core research approach and this underpins a quest for novel blood-based diagnostics for pregnancy disorders. It also enables collaboration with developers of blood handling medical devices such as those for mechanical circulatory support.    

Areas Of Expertise

Pregnancy Immunology
Immunometabolism
Placental Biology
Immune function in infancy
Global Challenges (Maternal & Neonatal Health)
Gestational diabetes, preeclampsia and cholestasis 
Novel blood-based diagnostics
Mechanical circulatory support device

Publications

Research Highlights

Nassar, M., Doan, M., Filby, A., Wolkenhauer, O., Fogg, D., Piasecka, J., Thornton, C., Carpenter, A., Summers, H., Rees, P., & Hennig, H. (2019). Label‐Free Identification of White Blood Cells Using Machine Learning. Cytometry Part A
https://doi.org/10.1002/cyto.a.23794, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50355
Jones, N., Vincent, E., Cronin, J., Panetti, S., Chambers, M., Holm, S., Owens, S., Francis, N., Finlay, D., & Thornton, C. (2019). Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation. Nature Communications, 10(1)
https://doi.org/10.1038/s41467-019-10023-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49646
Davies, L., Jones, R., & Thornton, C. (2019). Maternal serum, an isolation and expansion tool for umbilical cord matrix mesenchymal stromal cells. Tissue Engineering Part C: Methods
https://doi.org/10.1089/ten.TEC.2019.0008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49644
Radley, G., Pieper, I., Thomas, B., Hawkins, K., & Thornton, C. (2018). Artificial Shear Stress Effects on Leukocytes at a Biomaterial Interface. Artificial Organs
https://doi.org/10.1111/aor.13409, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49111
Radley, G., Pieper, I., Ali, S., Bhatti, F., & Thornton, C. (2018). The Inflammatory Response to Ventricular Assist Devices. Frontiers in Immunology, 9
https://doi.org/10.3389/fimmu.2018.02651, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45954
Radley, G., Ali, S., Pieper, I., & Thornton, C. (2018). Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use. The International Journal of Artificial Organs, 039139881881732
https://doi.org/10.1177/0391398818817326, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45953
Jenkins, C., Jenkins, R., Pryse, M., Welsby, K., Jitsumura, M., Thornton, C., Dunstan, P., & Harris, D. (2018). A high-throughput serum Raman spectroscopy platform and methodology for colorectal cancer diagnostics. The Analyst, 143(24), 6014-6024.
https://doi.org/10.1039/c8an01323c, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45504
Jones, N., Cronin, J., Dolton, G., Panetti, S., Schauenburg, A., Galloway, S., Sewell, A., Cole, D., Thornton, C., & Francis, N. (2017). Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation. Frontiers in Immunology, 8(1516)
https://doi.org/10.3389/fimmu.2017.01516, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36275
Pieper, I., Radley, G., Christen, A., Ali, S., Bodger, O., & Thornton, C. (2018). Ovine leukocyte microparticles generated by the CentriMag ventricular assist device in vitro. Artificial Organs
https://doi.org/10.1111/aor.13068, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36276
Radley, G., Pieper, I., & Thornton, C. (2017). The effect of ventricular assist device-associated biomaterials on human blood leukocytes. Journal of Biomedical Materials Research Part B: Applied Biomaterials
https://doi.org/10.1002/jbm.b.33981, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34948
Bryant, A., Bevan, R., Spencer-Harty, S., Scott, L., Jones, R., & Thornton, C. (2017). Expression and function of NOD-like receptors by human term gestation-associated tissues. Placenta, 58, 25-32.
https://doi.org/10.1016/j.placenta.2017.07.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34833
Rees, A., Scott, L., Bryant, A., Rees, A., Down, B., Jones, R., & Thornton, C. (2017). Production and regulation of interleukin-1 family cytokines at the materno-fetal interface. Cytokine, 99, 194-202.
https://doi.org/10.1016/j.cyto.2017.07.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34588
Skevaki, C., Van den Berg, J., Jones, N., Garssen, J., Vuillermin, P., Levin, M., Landay, A., Renz, H., Calder, P., & Thornton, C. (2016). Immune biomarkers in the spectrum of childhood noncommunicable diseases. Journal of Allergy and Clinical Immunology, 137(5), 1302-1316.
https://doi.org/10.1016/j.jaci.2016.03.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31188
Bryant, A., Spencer-Harty, S., Owens, S., Jones, R., & Thornton, C. (2017). Interleukin 4 and interleukin 13 downregulate the lipopolysaccharide-mediated inflammatory response by human gestation-associated tissues†. Biology of Reproduction, 96(3), 576-586.
https://doi.org/10.1095/biolreprod.116.145680, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31647
Chan, C., Pieper, I., Robinson, C., Friedmann, Y., Kanamarlapudi, V., & Thornton, C. (2017). Shear Stress-Induced Total Blood Trauma in Multiple Species. Artificial Organs
https://doi.org/10.1111/aor.12932, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31746
Al-Himdani, S., Jessop, Z., Al-Sabah, A., Combellack, E., Ibrahim, A., Doak, S., Hart, A., Archer, C., Thornton, C., & Whitaker, I. (2017). Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice. Frontiers in Surgery, 4, article 4
https://doi.org/10.3389/fsurg.2017.00004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31747
http://journal.frontiersin.org/article/10.3389/fsurg.2017.00004/full
Thornton, C. & Marsland, B. (2016). A Trajectory toward Allergy:In UteroUptake of Allergens Can Prime Type 2 Inflammation. American Journal of Respiratory and Critical Care Medicine, 194(8), 919-920.
https://doi.org/10.1164/rccm.201604-0783ED, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31189
Patni, S., Bryant, A., Wynen, L., Seager, A., Morgan, G., & Thornton, C. (2015). Functional activity but not gene expression of toll-like receptors is decreased in the preterm versus term human placenta. Placenta, 36(9), 1031-1038.
https://doi.org/10.1016/j.placenta.2015.06.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23518
Jones, N., Piasecka, J., Bryant, A., Jones, R., Skibinski, D., Francis, N., Thornton, C., Skibinski, D., Jones, R., Thornton, C., Bryant, A., & Jones, N. (2015). Bioenergetic analysis of human peripheral blood mononuclear cells. Clinical & Experimental Immunology, 182(1), 69-80.
https://doi.org/10.1111/cei.12662, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23517
Catling, S., Thornton, C., Russell, I., & Thornton, C. (2015). Bradykinin and cysteinyl leukotriene concentrations in cell-salvaged blood before and after passage through negatively charged filters during clinical use in cancer patients: a pilot study. Anaesthesia, 70(9), 1066-1072.
https://doi.org/10.1111/anae.13100, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23516
Campbell, D., Boyle, R., Thornton, C., Prescott, S., & Thornton, C. (2015). Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy. Clinical & Experimental Allergy, 45(5), 844-858.
https://doi.org/10.1111/cea.12531, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23515
Zaragoza, O., Melo, N., Abdrahman, A., Greig, C., Mukherjee, K., Thornton, C., Ratcliffe, N., Vilcinskas, A., & Butt, T. (2013). Myriocin Significantly Increases the Mortality of a Non-Mammalian Model Host during Candida Pathogenesis. PLoS ONE, 8(11), e78905
https://doi.org/10.1371/journal.pone.0078905, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18308
Chan, C., Hilton, A., Foster, G., Hawkins, K., Badiei, N., & Thornton, C. (2013). The Evaluation of Leukocytes in Response to the In Vitro Testing of Ventricular Assist Devices. Artificial Organs, n/a-n/a.
https://doi.org/10.1111/aor.12161, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15872
Davies, L., Kiernan, M., Bishop, J., Thornton, C., & Morgan, G. (2013). The impact of cell culture equipment on energy loss.. Lasers in Medical Science
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15870
Zair, Z., Doak, S., Thornton, C., Jenkins, G., & Johnson, G. (2011). Assessment of human lymphoblastoid cell lines as suitable in vitro model systems in genetic toxicology.. Toxicological Sciences, 2-358.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15869
Tulic, M., Hodder, M., A Forsberg et, a., McCarthy, S., Richman, T., D'Vaz, N., Biggelaar, A., Thornton, C., Prescott, S., & Thornton, C. (2011). Differences in innate immune function between allergic and nonallergic children: new insights into immune ontogeny.. Journal of Allergy and Clinical Immunology, 127(2), 470-478.
https://doi.org/10.1016/j.jaci.2010.09.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9992
www.jacionline.org/article/S0091-6749(10)01487-9/abstract
Wootton, E., Zubkov, M., Jones, D., Jones, R., Martel, C., Thornton, C., Roberts, E., & Hull, C. (2007). Biochemical prey recognition by planktonic protozoa. Environmental Microbiology, 9(1), 216-222.
https://doi.org/10.1111/j.1462-2920.2006.01130.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1437
Prescott, S., Noakes, P., BW Chow et, a., Breckler, L., Thornton, C., Hollams, E., Ali, M., Biggelaar, A., Tulic, M., & Thornton, C. (2008). Presymptomatic differences in Toll-like receptor function in infants who have allergy.. Journal of Allergy and Clinical Immunology, 122(2), 391-399.
https://doi.org/10.1016/j.jaci.2008.04.042, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9991
http://www.sciencedirect.com/science/article/pii/S0091674908007884
Smith, M., Tourigny, M., Noakes, P., Thornton, C., Tulic, M., Prescott, S., & Thornton, C. (2008). Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function.. Journal of Allergy and Clinical Immunology, 121(6), 1460-1466.
https://doi.org/10.1016/j.jaci.2008.03.025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9993
http://www.sciencedirect.com/science/article/pii/S009167490800609X
Breckler, L., Hale, J., Taylor, A., Dunstan, J., Thornton, C., Prescott, S., & Thornton, C. (2008). Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.. Allergy, 63(11), 1473-1480.
https://doi.org/10.1111/j.1398-9995.2008.01718.x., SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9994
http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2008.01718.x/pdf
Summers, H., Holton, M., P Rees et, a., & Thornton, C. (2010). Analysis of quantum dot fluorescence stability in primary blood mononuclear cells.. Cytometry A, 933-9.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10150
Patni, S., Wynen, L., Seager, A., Morgan, G., White, J., & Thornton, C. (2009). Expression and Activity of Toll-Like Receptors 1–9 in the Human Term Placenta and Changes Associated with Labor at Term. Biology of Reproduction, 80(2), 243-248.
https://doi.org/10.1095/biolreprod.108.069252, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10151
Macfarlane, T., Seager, A., Moller, M., Morgan, G., & Thornton, C. (2010). Thymic stromal lymphopoietin is present in human breast milk. Pediatric Allergy and Immunology, 21(2p2), e454-e456.
https://doi.org/10.1111/j.1399-3038.2009.00916.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10152
Thornton, C., Holloway, J., JK Shute et, a., & Thornton, C. (2009). Human mid-gestation amniotic fluid contains interleukin-16 bioactivity.. Immunology, 543-551.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10153
Holloway, J., Thornton, C., alk, N., & Thornton, C. (2009). Phenotypic analysis of circulating dendritic cells during the second half of human gestation.. Pediatric Allergy and Immunology, 119-125.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10154
Gordon, J., Prothero, J., Thornton, C., Pickard, K., Di Sabatino, A., Goggin, P., Pender, S., MacDonald, T., & Thornton, C. (2009). CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-α and MMP-3 production in patients with inflammatory bowel disease. Journal of Crohn's and Colitis, 3(3), 175-182.
https://doi.org/10.1016/j.crohns.2009.03.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25941
Brackler, L., Hale, J., W Jung et, a., & Thornton, C. (2010). Modulation of in vivo and in vitro cytokine production over the course of pregnancy in allergic and non-allergic mothers.. Pediatric Allergy and Immunology, 14-21.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10155
Thornton, C., Jones, R., & Bryant, A. (2011). Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development. Advances in Neuroimmune Biology, 1(2), 193-203.
https://doi.org/10.3233/NIB-2011-015, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12678
http://iospress.metapress.com/content/xm2k364n99347t67/?p=b56bc6f21c9e4e298f04f07aa7f3b7d6&pi=7
Upham, J., Holt, P., Taylor, A., Thornton, C., & Prescott, S. (2004). HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responses. Journal of Allergy and Clinical Immunology, 114(5), 1202-1208.
https://doi.org/10.1016/j.jaci.2004.06.051, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1436
Jordan, S., Watkins, A., Storey, M., Allen, S., Brooks, C., Garaiova, I., Heaven, M., Jones, R., Plummer, S., Russell, I., Thornton, C., Morgan, G., & Storey, M. (2013). Volunteer Bias in Recruitment, Retention, and Blood Sample Donation in a Randomised Controlled Trial Involving Mothers and Their Children at Six Months and Two Years: A Longitudinal Analysis. PLoS ONE, 8(7), e67912
https://doi.org/10.1371/journal.pone.0067912, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15457
Allen, S., Jordan, S., Storey, M., Thornton, C., Gravenor, M., Garaiova, I., Plummer, S., Wang, D., & Morgan, G. (2014). Probiotics in the prevention of eczema: a randomised controlled trial. Archives of Disease in Childhood, 99(11), 1014-1019.
https://doi.org/10.1136/archdischild-2013-305799, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18103
Chan, C., Pieper, I., Hambly, R., Radley, G., Jones, A., Friedmann, Y., Hawkins, K., Westaby, S., Foster, G., & Thornton, C. (2015). The CentriMag Centrifugal Blood Pump as a Benchmark for In Vitro Testing of Hemocompatibility in Implantable Ventricular Assist Devices. Artificial Organs, 39(2), 93-101.
https://doi.org/10.1111/aor.12351, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18432
Chan, C., Pieper, I., Fleming, S., Friedmann, Y., Foster, G., Hawkins, K., Thornton, C., & Kanamarlapudi, V. (2014). The Effect of Shear Stress on the Size, Structure, and Function of Human von Willebrand Factor. Artificial Organs, 38(9), 741-750.
https://doi.org/10.1111/aor.12382, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18740
Naderi, N., Wilde, C., Haque, T., Francis, W., Seifalian, A., Thornton, C., Xia, Z., & Whitaker, I. (2014). Adipogenic differentiation of adipose-derived stem cells in 3-dimensional spheroid cultures (microtissue): Implications for the reconstructive surgeon. Journal of Plastic, Reconstructive & Aesthetic Surgery, 67(12), 1726-1734.
https://doi.org/10.1016/j.bjps.2014.08.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18931
Thornton, C., Cronin, J., Kanamarlapudi, V., & Sheldon, M. (2016). Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunology, 9(4), 1125-1136.
https://doi.org/10.1038/mi.2015.131, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25017
http://www.nature.com/mi/journal/vaop/ncurrent/full/mi2015131a.html
Pieper, I., Friedmann, Y., Jones, A., & Thornton, C. (2016). Evaluation of Four Veterinary Hematology Analyzers for Bovine and Ovine Blood Counts for In Vitro Testing of Medical Devices. Artificial Organs, 40(11), 1054-1061.
https://doi.org/10.1111/aor.12703, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28248
Pieper, I., Radley, G., Chan, C., Friedmann, Y., Foster, G., & Thornton, C. (2016). Quantification methods for human and large animal leukocytes using DNA dyes by flow cytometry. Cytometry Part A, 89(6), 565-574.
https://doi.org/10.1002/cyto.a.22874, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28731
Verma, J., Rees, B., Wilde, E., Thornton, C., Jenkins, G., Doak, S., Johnson, G., Thornton, C., Jenkins, G., & Johnson, G. (2016). Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells. Archives of Toxicology, 91(7), 2689-2698.
https://doi.org/10.1007/s00204-016-1903-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31363
Bryant, A., Menzies, G., Scott, L., Spencer-Harty, S., Davies, L., Smith, R., Jones, R., Thornton, C., Jones, R., Thornton, C., & Bryant, A. (2017). Human gestation-associated tissues express functional cytosolic nucleic acid sensing pattern recognition receptors. Clinical & Experimental Immunology
https://doi.org/10.1111/cei.12960, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32814
Zhang, Y., Morgan, B., Smith, R., Fellows, C., Thornton, C., Snow, M., Francis, L., & Khan, I. (2017). Platelet-rich plasma induces post-natal maturation of immature articular cartilage and correlates with LOXL1 activation. Scientific Reports, 7(1)
https://doi.org/10.1038/s41598-017-02297-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33950

All Research

Journal Articles

Jovic, T., Thomson, E., Jones, N., Thornton, C., Doak, S., & Whitaker, I. (2024). Nasoseptal chondroprogenitors isolated through fibronectin-adherence confer no biological advantage for cartilage tissue engineering compared to nasoseptal chondrocytes.. Frontiers in Bioengineering and Biotechnology, 12
https://doi.org/10.3389/fbioe.2024.1421111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68056
Rees, A., Jenkins, B., Angelini, R., Davies, L., Cronin, J., Jones, N., & Thornton, C. (2024). Immunometabolic adaptation in monocytes underpins functional changes during pregnancy. iScience, 27(5), 109779
https://doi.org/10.1016/j.isci.2024.109779, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66076
Yasim Farook, M., Croxford, Z., Morgan, S., Horlock, A., Holt, A., Rees, A., Jenkins, B., TSE, C., Stanton, E., Davies, D., Thornton, C., Jones, N., Sheldon, M., Vincent, E., & Cronin, J. (2024). Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer. Molecular Metabolism, 81
https://doi.org/10.1016/j.molmet.2024.101900, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65663
Jenkins, B., Blagih, J., Ponce Garcia, F., Canavan, M., Gudgeon, N., Eastham, S., Hill, D., Hanlon, M., Ma, E., Bishop, E., Rees, A., Cronin, J., Jury, E., Dimeloe, S., Veale, D., Thornton, C., Vousden, K., Finlay, D., Fearon, U...., & Jones, N. (2023). Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity. Cell Metabolism, 35(7), 1132-1146.e9.
https://doi.org/10.1016/j.cmet.2023.05.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63534
http://dx.doi.org/10.1016/j.cmet.2023.05.001
Dickson, A., Yutuc, E., Thornton, C., Dunford, J., Oppermann, U., Wang, Y., & Griffiths, W. (2023). HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta. Open Biology, 13(5)
https://doi.org/10.1098/rsob.220313, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61629
http://dx.doi.org/10.1098/rsob.220313
Rees, A., Edwards-I-Coll, Z., Richards, O., Raikes, M., Angelini, R., & Thornton, C. (2023). The dynamic inflammatory profile of pregnancy can be monitored using a novel lipid-based mass spectrometry technique. Molecular Omics, 19(4), 340-350.
https://doi.org/10.1039/d2mo00294a, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63196
http://dx.doi.org/10.1039/d2mo00294a
Dickson, A., Yutuc, E., Thornton, C., Wang, Y., & Griffiths, W. (2022). Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry. Frontiers in Endocrinology, 13
https://doi.org/10.3389/fendo.2022.1031013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61630
Evans, B., Akbari, A., Bailey, R., Bethell, L., Bufton, S., Carson-Stevens, A., Dixon, L., Edwards, A., John, A., Jolles, S., Kingston, M., Lyons, J., Lyons, R., Porter, A., Sewell, B., Thornton, C., Watkins, A., Whiffen, T., & Snooks, H. (2022). Evaluation of the shielding initiative in Wales (EVITE Immunity): protocol for a quasiexperimental study. BMJ Open, 12(9), e059813
https://doi.org/10.1136/bmjopen-2021-059813, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60455
Rees, A., Richards, O., Chambers, M., Jenkins, B., Cronin, J., & Thornton, C. (2022). Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity. Clinical and Experimental Immunology, 208(2), 132-146.
https://doi.org/10.1093/cei/uxac003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60422
Rees, A., Richards, O., Allen-Kormylo, A., Jones, N., & Thornton, C. (2022). Maternal body mass index is associated with an altered immunological profile at 28 weeks of gestation. Clinical and Experimental Immunology, 208(1), 114-128.
https://doi.org/10.1093/cei/uxac023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60423
Holm, S., Jenkins, B., Cronin, J., Jones, N., & Thornton, C. (2021). A role for metabolism in determining neonatal immune function. Pediatric Allergy and Immunology, 32(8), 1616-1628.
https://doi.org/10.1111/pai.13583, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58165
Rees, A., Turner, S., & Thornton, C. (2021). Potential protective effects of breast milk and amniotic fluid against novel coronavirus SARS‐CoV‐2 through decoy receptors. Pediatric Allergy and Immunology, 33(1)
https://doi.org/10.1111/pai.13672, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58308
Jenkins, B., Rees, A., Jones, N., & Thornton, C. (2021). Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?. Immunometabolism, 3(4), e210031
https://doi.org/10.20900/immunometab20210031, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58734
Wills, J., Verma, J., Rees, B., Harte, D., Haxhiraj, C., Barnes, C., Barnes, R., Rodrigues, M., Doan, M., Filby, A., Hewitt, R., Thornton, C., Cronin, J., Kenny, J., Buckley, R., Lynch, A., Carpenter, A., Summers, H., Johnson, G., & Rees, P. (2021). Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning. Archives of Toxicology, 95(9), 3101-3115.
https://doi.org/10.1007/s00204-021-03113-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57403
Jones, N., Blagih, J., Zani, F., Rees, A., Hill, D., Jenkins, B., Bull, C., Moreira, D., Bantan, A., Cronin, J., Avancini, D., Jones, G., Finlay, D., Vousden, K., Vincent, E., & Thornton, C. (2021). Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation. Nature Communications, 12(1)
https://doi.org/10.1038/s41467-021-21461-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56336
Jessop, Z., Alsabah, A., Neves Simoes, I., Burnell, S., Pieper, I., Thornton, C., & Whitaker, I. (2020). Isolation and characterisation of nasoseptal cartilage stem/progenitor cells and their role in the chondrogenic niche. Stem Cell Research & Therapy, 11(1)
https://doi.org/10.1186/s13287-020-01663-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55803
Thomas, B., Hambly, R., Weisel, J., Rauova, L., Badiei, N., Brown, R., Thornton, C., Williams, R., & Hawkins, K. (2020). Abnormal clot microstructure formed in blood containing HIT-like antibodies. Thrombosis Research, 193, 25-30.
https://doi.org/10.1016/j.thromres.2020.05.029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54403
Sala, A., Spalding, K., Ashton, K., Board, R., Butler, H., Dawson, T., Harris, D., Hughes, C., Jenkins, C., Jenkinson, M., Palmer, D., Smith, B., Thornton, C., & Baker, M. (2020). Rapid analysis of disease state in liquid human serum combining infrared spectroscopy and “digital drying”. Journal of Biophotonics, 13(9)
https://doi.org/10.1002/jbio.202000118, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54465
Jovic, T., Ali, S., Ibrahim, N., Jessop, Z., Tarassoli, S., Dobbs, T., Holford, P., Thornton, C., & Whitaker, I. (2020). Could Vitamins Help in the Fight Against COVID-19?. Nutrients, 12(9), 2550
https://doi.org/10.3390/nu12092550, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55098
Jones, N., Vincent, E., Felix, L., Cronin, J., Scott, L., Hole, P., Lacy, P., & Thornton, C. (2020). Interleukin‐5 drives glycolysis and reactive oxygen species‐dependent citric acid cycling by eosinophils. Allergy, 75(6), 1361-1370.
https://doi.org/10.1111/all.14158, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53068
http://dx.doi.org/10.1111/all.14158
Piasecka, J., Thornton, C., Rees, P., & Summers, H. (2020). Diffusion Mapping of Eosinophil‐Activation State. Cytometry Part A, 97(3), 253-258.
https://doi.org/10.1002/cyto.a.23884, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51589
Radley, G., Pieper, I., Robinson, C., Ali, S., Beshr, M., Bodger, O., & Thornton, C. (2020). In Vitro Benchmarking Study of Ventricular Assist Devices in Current Clinical Use. Journal of Cardiac Failure, 26(1), 70-79.
https://doi.org/10.1016/j.cardfail.2019.09.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53010
Nassar, M., Doan, M., Filby, A., Wolkenhauer, O., Fogg, D., Piasecka, J., Thornton, C., Carpenter, A., Summers, H., Rees, P., & Hennig, H. (2019). Label‐Free Identification of White Blood Cells Using Machine Learning. Cytometry Part A
https://doi.org/10.1002/cyto.a.23794, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50355
Jessop, Z., Manivannan, S., ZHANG, Y., Thornton, C., Narayan, R., & Whitaker, I. (2019). Tissue specific stem/progenitor cells for cartilage tissue engineering: A systematic review of the literature. Applied Physics Reviews, 6(3), 031301
https://doi.org/10.1063/1.5050814, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51115
Jones, N., Vincent, E., Cronin, J., Panetti, S., Chambers, M., Holm, S., Owens, S., Francis, N., Finlay, D., & Thornton, C. (2019). Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation. Nature Communications, 10(1)
https://doi.org/10.1038/s41467-019-10023-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49646
Davies, L., Jones, R., & Thornton, C. (2019). Maternal serum, an isolation and expansion tool for umbilical cord matrix mesenchymal stromal cells. Tissue Engineering Part C: Methods
https://doi.org/10.1089/ten.TEC.2019.0008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49644
Radley, G., Ali, S., Pieper, I., & Thornton, C. (2018). Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use. The International Journal of Artificial Organs, 039139881881732
https://doi.org/10.1177/0391398818817326, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45953
Radley, G., Pieper, I., Ali, S., Bhatti, F., & Thornton, C. (2018). The Inflammatory Response to Ventricular Assist Devices. Frontiers in Immunology, 9
https://doi.org/10.3389/fimmu.2018.02651, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45954
Jenkins, C., Jenkins, R., Pryse, M., Welsby, K., Jitsumura, M., Thornton, C., Dunstan, P., & Harris, D. (2018). A high-throughput serum Raman spectroscopy platform and methodology for colorectal cancer diagnostics. The Analyst, 143(24), 6014-6024.
https://doi.org/10.1039/c8an01323c, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45504
Pieper, I., Radley, G., Christen, A., Ali, S., Bodger, O., & Thornton, C. (2018). Ovine leukocyte microparticles generated by the CentriMag ventricular assist device in vitro. Artificial Organs
https://doi.org/10.1111/aor.13068, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36276
Radley, G., Pieper, I., Thomas, B., Hawkins, K., & Thornton, C. (2018). Artificial Shear Stress Effects on Leukocytes at a Biomaterial Interface. Artificial Organs
https://doi.org/10.1111/aor.13409, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49111
Jones, N., Cronin, J., Dolton, G., Panetti, S., Schauenburg, A., Galloway, S., Sewell, A., Cole, D., Thornton, C., & Francis, N. (2017). Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation. Frontiers in Immunology, 8(1516)
https://doi.org/10.3389/fimmu.2017.01516, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36275
Bryant, A., Menzies, G., Scott, L., Spencer-Harty, S., Davies, L., Smith, R., Jones, R., Thornton, C., Jones, R., Thornton, C., & Bryant, A. (2017). Human gestation-associated tissues express functional cytosolic nucleic acid sensing pattern recognition receptors. Clinical & Experimental Immunology
https://doi.org/10.1111/cei.12960, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32814
Zhang, Y., Morgan, B., Smith, R., Fellows, C., Thornton, C., Snow, M., Francis, L., & Khan, I. (2017). Platelet-rich plasma induces post-natal maturation of immature articular cartilage and correlates with LOXL1 activation. Scientific Reports, 7(1)
https://doi.org/10.1038/s41598-017-02297-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33950
Rees, A., Scott, L., Bryant, A., Rees, A., Down, B., Jones, R., & Thornton, C. (2017). Production and regulation of interleukin-1 family cytokines at the materno-fetal interface. Cytokine, 99, 194-202.
https://doi.org/10.1016/j.cyto.2017.07.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34588
Bryant, A., Bevan, R., Spencer-Harty, S., Scott, L., Jones, R., & Thornton, C. (2017). Expression and function of NOD-like receptors by human term gestation-associated tissues. Placenta, 58, 25-32.
https://doi.org/10.1016/j.placenta.2017.07.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34833
Radley, G., Pieper, I., & Thornton, C. (2017). The effect of ventricular assist device-associated biomaterials on human blood leukocytes. Journal of Biomedical Materials Research Part B: Applied Biomaterials
https://doi.org/10.1002/jbm.b.33981, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34948
Chan, C., Pieper, I., Robinson, C., Friedmann, Y., Kanamarlapudi, V., & Thornton, C. (2017). Shear Stress-Induced Total Blood Trauma in Multiple Species. Artificial Organs
https://doi.org/10.1111/aor.12932, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31746
Bryant, A., Spencer-Harty, S., Owens, S., Jones, R., & Thornton, C. (2017). Interleukin 4 and interleukin 13 downregulate the lipopolysaccharide-mediated inflammatory response by human gestation-associated tissues†. Biology of Reproduction, 96(3), 576-586.
https://doi.org/10.1095/biolreprod.116.145680, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31647
Rees, B., Tate, M., Lynch, A., Thornton, C., Jenkins, G., Walmsley, R., & Johnson, G. (2017). Development of anin vitro PIG-Agene mutation assay in human cells. Mutagenesis, 32(2), 283-297.
https://doi.org/10.1093/mutage/gew059, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55073
Al-Himdani, S., Jessop, Z., Al-Sabah, A., Combellack, E., Ibrahim, A., Doak, S., Hart, A., Archer, C., Thornton, C., & Whitaker, I. (2017). Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice. Frontiers in Surgery, 4, article 4
https://doi.org/10.3389/fsurg.2017.00004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31747
http://journal.frontiersin.org/article/10.3389/fsurg.2017.00004/full
Pieper, I., Friedmann, Y., Jones, A., & Thornton, C. (2016). Evaluation of Four Veterinary Hematology Analyzers for Bovine and Ovine Blood Counts for In Vitro Testing of Medical Devices. Artificial Organs, 40(11), 1054-1061.
https://doi.org/10.1111/aor.12703, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28248
Verma, J., Rees, B., Wilde, E., Thornton, C., Jenkins, G., Doak, S., Johnson, G., Thornton, C., Jenkins, G., & Johnson, G. (2016). Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells. Archives of Toxicology, 91(7), 2689-2698.
https://doi.org/10.1007/s00204-016-1903-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31363
Thornton, C. & Marsland, B. (2016). A Trajectory toward Allergy:In UteroUptake of Allergens Can Prime Type 2 Inflammation. American Journal of Respiratory and Critical Care Medicine, 194(8), 919-920.
https://doi.org/10.1164/rccm.201604-0783ED, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31189
Thornton, C., Cronin, J., Kanamarlapudi, V., & Sheldon, M. (2016). Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunology, 9(4), 1125-1136.
https://doi.org/10.1038/mi.2015.131, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25017
http://www.nature.com/mi/journal/vaop/ncurrent/full/mi2015131a.html
Pieper, I., Radley, G., Chan, C., Friedmann, Y., Foster, G., & Thornton, C. (2016). Quantification methods for human and large animal leukocytes using DNA dyes by flow cytometry. Cytometry Part A, 89(6), 565-574.
https://doi.org/10.1002/cyto.a.22874, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28731
Skevaki, C., Van den Berg, J., Jones, N., Garssen, J., Vuillermin, P., Levin, M., Landay, A., Renz, H., Calder, P., & Thornton, C. (2016). Immune biomarkers in the spectrum of childhood noncommunicable diseases. Journal of Allergy and Clinical Immunology, 137(5), 1302-1316.
https://doi.org/10.1016/j.jaci.2016.03.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31188
Jones, N., Piasecka, J., Bryant, A., Jones, R., Skibinski, D., Francis, N., Thornton, C., Skibinski, D., Jones, R., Thornton, C., Bryant, A., & Jones, N. (2015). Bioenergetic analysis of human peripheral blood mononuclear cells. Clinical & Experimental Immunology, 182(1), 69-80.
https://doi.org/10.1111/cei.12662, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23517
Catling, S., Thornton, C., Russell, I., & Thornton, C. (2015). Bradykinin and cysteinyl leukotriene concentrations in cell-salvaged blood before and after passage through negatively charged filters during clinical use in cancer patients: a pilot study. Anaesthesia, 70(9), 1066-1072.
https://doi.org/10.1111/anae.13100, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23516
Campbell, D., Boyle, R., Thornton, C., Prescott, S., & Thornton, C. (2015). Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy. Clinical & Experimental Allergy, 45(5), 844-858.
https://doi.org/10.1111/cea.12531, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23515
Chan, C., Pieper, I., Hambly, R., Radley, G., Jones, A., Friedmann, Y., Hawkins, K., Westaby, S., Foster, G., & Thornton, C. (2015). The CentriMag Centrifugal Blood Pump as a Benchmark for In Vitro Testing of Hemocompatibility in Implantable Ventricular Assist Devices. Artificial Organs, 39(2), 93-101.
https://doi.org/10.1111/aor.12351, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18432
Patni, S., Bryant, A., Wynen, L., Seager, A., Morgan, G., & Thornton, C. (2015). Functional activity but not gene expression of toll-like receptors is decreased in the preterm versus term human placenta. Placenta, 36(9), 1031-1038.
https://doi.org/10.1016/j.placenta.2015.06.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23518
Chan, C., Pieper, I., Fleming, S., Friedmann, Y., Foster, G., Hawkins, K., Thornton, C., & Kanamarlapudi, V. (2014). The Effect of Shear Stress on the Size, Structure, and Function of Human von Willebrand Factor. Artificial Organs, 38(9), 741-750.
https://doi.org/10.1111/aor.12382, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18740
Naderi, N., Wilde, C., Haque, T., Francis, W., Seifalian, A., Thornton, C., Xia, Z., & Whitaker, I. (2014). Adipogenic differentiation of adipose-derived stem cells in 3-dimensional spheroid cultures (microtissue): Implications for the reconstructive surgeon. Journal of Plastic, Reconstructive & Aesthetic Surgery, 67(12), 1726-1734.
https://doi.org/10.1016/j.bjps.2014.08.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18931
Allen, S., Jordan, S., Storey, M., Thornton, C., Gravenor, M., Garaiova, I., Plummer, S., Wang, D., & Morgan, G. (2014). Probiotics in the prevention of eczema: a randomised controlled trial. Archives of Disease in Childhood, 99(11), 1014-1019.
https://doi.org/10.1136/archdischild-2013-305799, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18103
Zaragoza, O., Melo, N., Abdrahman, A., Greig, C., Mukherjee, K., Thornton, C., Ratcliffe, N., Vilcinskas, A., & Butt, T. (2013). Myriocin Significantly Increases the Mortality of a Non-Mammalian Model Host during Candida Pathogenesis. PLoS ONE, 8(11), e78905
https://doi.org/10.1371/journal.pone.0078905, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18308
Chan, C., Hilton, A., Foster, G., Hawkins, K., Badiei, N., & Thornton, C. (2013). The Evaluation of Leukocytes in Response to the In Vitro Testing of Ventricular Assist Devices. Artificial Organs, n/a-n/a.
https://doi.org/10.1111/aor.12161, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15872
Davies, L., Kiernan, M., Bishop, J., Thornton, C., & Morgan, G. (2013). The impact of cell culture equipment on energy loss.. Lasers in Medical Science
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15870
Jordan, S., Watkins, A., Storey, M., Allen, S., Brooks, C., Garaiova, I., Heaven, M., Jones, R., Plummer, S., Russell, I., Thornton, C., Morgan, G., & Storey, M. (2013). Volunteer Bias in Recruitment, Retention, and Blood Sample Donation in a Randomised Controlled Trial Involving Mothers and Their Children at Six Months and Two Years: A Longitudinal Analysis. PLoS ONE, 8(7), e67912
https://doi.org/10.1371/journal.pone.0067912, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15457
Zair, Z., Doak, S., Thornton, C., Jenkins, G., & Johnson, G. (2011). Assessment of human lymphoblastoid cell lines as suitable in vitro model systems in genetic toxicology.. Toxicological Sciences, 2-358.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15869
Tulic, M., Hodder, M., A Forsberg et, a., McCarthy, S., Richman, T., D'Vaz, N., Biggelaar, A., Thornton, C., Prescott, S., & Thornton, C. (2011). Differences in innate immune function between allergic and nonallergic children: new insights into immune ontogeny.. Journal of Allergy and Clinical Immunology, 127(2), 470-478.
https://doi.org/10.1016/j.jaci.2010.09.020, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9992
www.jacionline.org/article/S0091-6749(10)01487-9/abstract
Thornton, C., Jones, R., & Bryant, A. (2011). Inflammation, Obesity, and Neuromodulation in Pregnancy and Fetal Development. Advances in Neuroimmune Biology, 1(2), 193-203.
https://doi.org/10.3233/NIB-2011-015, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12678
http://iospress.metapress.com/content/xm2k364n99347t67/?p=b56bc6f21c9e4e298f04f07aa7f3b7d6&pi=7
Summers, H., Holton, M., P Rees et, a., & Thornton, C. (2010). Analysis of quantum dot fluorescence stability in primary blood mononuclear cells.. Cytometry A, 933-9.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10150
Brackler, L., Hale, J., W Jung et, a., & Thornton, C. (2010). Modulation of in vivo and in vitro cytokine production over the course of pregnancy in allergic and non-allergic mothers.. Pediatric Allergy and Immunology, 14-21.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10155
Macfarlane, T., Seager, A., Moller, M., Morgan, G., & Thornton, C. (2010). Thymic stromal lymphopoietin is present in human breast milk. Pediatric Allergy and Immunology, 21(2p2), e454-e456.
https://doi.org/10.1111/j.1399-3038.2009.00916.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10152
Thornton, C., Holloway, J., JK Shute et, a., & Thornton, C. (2009). Human mid-gestation amniotic fluid contains interleukin-16 bioactivity.. Immunology, 543-551.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10153
Holloway, J., Thornton, C., alk, N., & Thornton, C. (2009). Phenotypic analysis of circulating dendritic cells during the second half of human gestation.. Pediatric Allergy and Immunology, 119-125.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10154
Gordon, J., Prothero, J., Thornton, C., Pickard, K., Di Sabatino, A., Goggin, P., Pender, S., MacDonald, T., & Thornton, C. (2009). CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-α and MMP-3 production in patients with inflammatory bowel disease. Journal of Crohn's and Colitis, 3(3), 175-182.
https://doi.org/10.1016/j.crohns.2009.03.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25941
Patni, S., Wynen, L., Seager, A., Morgan, G., White, J., & Thornton, C. (2009). Expression and Activity of Toll-Like Receptors 1–9 in the Human Term Placenta and Changes Associated with Labor at Term. Biology of Reproduction, 80(2), 243-248.
https://doi.org/10.1095/biolreprod.108.069252, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10151
Prescott, S., Noakes, P., BW Chow et, a., Breckler, L., Thornton, C., Hollams, E., Ali, M., Biggelaar, A., Tulic, M., & Thornton, C. (2008). Presymptomatic differences in Toll-like receptor function in infants who have allergy.. Journal of Allergy and Clinical Immunology, 122(2), 391-399.
https://doi.org/10.1016/j.jaci.2008.04.042, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9991
http://www.sciencedirect.com/science/article/pii/S0091674908007884
Smith, M., Tourigny, M., Noakes, P., Thornton, C., Tulic, M., Prescott, S., & Thornton, C. (2008). Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function.. Journal of Allergy and Clinical Immunology, 121(6), 1460-1466.
https://doi.org/10.1016/j.jaci.2008.03.025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9993
http://www.sciencedirect.com/science/article/pii/S009167490800609X
Breckler, L., Hale, J., Taylor, A., Dunstan, J., Thornton, C., Prescott, S., & Thornton, C. (2008). Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.. Allergy, 63(11), 1473-1480.
https://doi.org/10.1111/j.1398-9995.2008.01718.x., SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9994
http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2008.01718.x/pdf
Wootton, E., Zubkov, M., Jones, D., Jones, R., Martel, C., Thornton, C., Roberts, E., & Hull, C. (2007). Biochemical prey recognition by planktonic protozoa. Environmental Microbiology, 9(1), 216-222.
https://doi.org/10.1111/j.1462-2920.2006.01130.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1437
Upham, J., Holt, P., Taylor, A., Thornton, C., & Prescott, S. (2004). HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responses. Journal of Allergy and Clinical Immunology, 114(5), 1202-1208.
https://doi.org/10.1016/j.jaci.2004.06.051, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1436

Book Chapters

Al-Sabah, A., Jessop, Z., Whitaker, I., Thornton, C., Thornton, C., & Jessop, Z. (2018). Cell preparation for 3D bioprinting. 3D Bioprinting for Reconstructive Surgery (pp. 75-88). Woodhead Publishing
https://doi.org/10.1016/B978-0-08-101103-4.00006-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45044

Supervision

The impacts of the COVID-19 pandemic on fertility and maternal and neonatal health outcomes. (current)

PhD

Other supervisor: Prof Lucy Griffiths
Effects of micro- and nanoplastics on innate and inflammatory responses at the materno-fetal interface. (current)

PhD

Other supervisor: Prof Rich Fry
Investigating Changes in Human Serum and Their Potential Association with Cancer Using Raman Spectroscopy and Machine Learning (current)

PhD

Other supervisor: Dr Laura Thomas
Exploring abhydrolase domain containing proteins as therapeutic targets in T-cell mediated autoimmune disorders (current)

PhD

Other supervisor: Dr Nick Jones
The role of placental extracellular vesicles in the beneficial effects of pregnancy on multiple sclerosis (current)

PhD

Other supervisor: Dr Owain Howell
Mechanisms and origins of spectral signatures defining colorectal cancer and polyp/adenoma detection in Raman spectroscopy. (current)

PhD

Other supervisor: Prof Peter Dunstan
Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity. (awarded 2023)

PhD

Other supervisor: Dr Nick Jones
Immunometabolic Control of Placental Macrophages (awarded 2024)

PhD

Other supervisor: Dr Nick Jones
Metabolic regulation of innate and adaptive immune responses of neonates. (awarded 2024)

PhD

Other supervisor: Dr Nick Jones
Disrupting the diagnostic paradigm of gestational diabetes mellitus using blood-based vibrational spectroscopy. (awarded 2024)

PhD

Other supervisor: Dr Ed Dudley
Development of bioanalytical thin layer chromatography TLC and MALDI ToF mass spectrometry to support separation and identification of human placenta and blood plasma lipids (current)

PhD

Other supervisor: Dr Ed Dudley
Monocyte-Derived Osteoclasts as a Platform for Investigating Standard and Novel Treatments for Multiple Myeloma Bone Disease (awarded 2024)

PhD

Other supervisor: Dr James Cronin
Exploring metabolomics biomarkers using mass spectrometry techniques (current)

PhD

Other supervisor: Dr Ed Dudley
Untitled (current)

MSc

Other supervisor: Prof Rich Fry
Functional effects of nanoplastics on maternal and fetal innate immune cells (current)

MSc

Other supervisor: Prof Rich Fry

Taught Modules

PM-249 Human Immunology

The course is designed as an introduction to immunology and the human immune system. The course covers the fundamentals of immunology including functional perturbations associated with disease and experimental approaches to the study of immunology.
PM-249C Imiwnoleg Ddynol

Mae'r cwrs wedi'i gynllunio i fod yn gyflwyniad i imiwnoleg a'r system imiwnedd ddynol. Mae'r cwrs yn cyflwyno hanfodion imiwnoleg, gan gynnwys aflonyddiadau gweithrediadol sy'n gysylltiedig â chlefyd ac ymagweddau arbrofol at astudio imiwnoleg.
PM-341 Human Biology and the Environment

This module is intended to provide an understanding of how our environmental factors impact on key aspects of human biology. Various environmental factors such as diet, stress, and pollution will be considered with a focus on their effects on epigenetics, inflammation, gut microbiota, mitochondrial health, and oxidative stress in non-communicable diseases in particular (e.g. chronic respiratory disease, cancer and metabolic disorders). The effect of extreme environments (e.g. altitude, space) and ageing on multiple organ systems will be considered. Students will gain practical experience in communicating these issues to scientific and non-scientific audiences.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-347 Human Immunopathology

The module aims to provide students with a greater understanding of the human immune system and the causes of a range of diseases associated with immune dysfunction including autoimmune diseases, metabolic disorders and neurological conditions.
PM-352 Reproductive Biology and Medicine

This module is designed to provide students with knowledge of the biochemistry, physiology and pathology of human pregnancy, fetal development, parturition and menopause. Particular focus will be given to fertility treatments and pharmacological interventions of menopause. Lectures will cover a recap of endocrinology of reproduction, and provide details of assisted reproductive technologies. Lectures will be supported by case studies which include current clinical approaches used to treat infertility (both male and female) and menopause.
PM-374 Child Health

This module aims to provide a critical overview of the epidemiology of common causes of morbidity and mortality in school-aged children and adolescents. It will cover individual conditions, links between physical and mental health, determinants of health with a focus on socio-economic inequalities, public health universal services to improve health. Further, it will cover links to educational outcomes.
PMLM01 Laboratory Measurement Techniques for Medicinal Chemistry and Nanomedicine

This module will enable students to understand the basic and advanced concepts of measurement techniques used in medicinal chemistry and nanomedicine, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.
PMLM22 Laboratory Measurement Techniques for Medical Sciences

This module will enable students to understand the basic and advanced concepts of laboratory and measurement techniques used in medical sciences, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.

Career History

Designated Individual for HTA Human Tissue Research Licence  , Swansea University

2016 - Present

Professor Cathy Thornton

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Supervision

The impacts of the COVID-19 pandemic on fertility and maternal and neonatal health outcomes. (current)

Effects of micro- and nanoplastics on innate and inflammatory responses at the materno-fetal interface. (current)

Investigating Changes in Human Serum and Their Potential Association with Cancer Using Raman Spectroscopy and Machine Learning (current)

Exploring abhydrolase domain containing proteins as therapeutic targets in T-cell mediated autoimmune disorders (current)

The role of placental extracellular vesicles in the beneficial effects of pregnancy on multiple sclerosis (current)

Mechanisms and origins of spectral signatures defining colorectal cancer and polyp/adenoma detection in Raman spectroscopy. (current)

Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity. (awarded 2023)

Immunometabolic Control of Placental Macrophages (awarded 2024)

Metabolic regulation of innate and adaptive immune responses of neonates. (awarded 2024)

Disrupting the diagnostic paradigm of gestational diabetes mellitus using blood-based vibrational spectroscopy. (awarded 2024)

Development of bioanalytical thin layer chromatography TLC and MALDI ToF mass spectrometry to support separation and identification of human placenta and blood plasma lipids (current)

Monocyte-Derived Osteoclasts as a Platform for Investigating Standard and Novel Treatments for Multiple Myeloma Bone Disease (awarded 2024)

Exploring metabolomics biomarkers using mass spectrometry techniques (current)

Untitled (current)

Functional effects of nanoplastics on maternal and fetal innate immune cells (current)

Taught Modules

PM-249 Human Immunology

PM-249C Imiwnoleg Ddynol

PM-341 Human Biology and the Environment

PM-344 Capstone Project

PM-347 Human Immunopathology

PM-352 Reproductive Biology and Medicine

PM-374 Child Health

PMLM01 Laboratory Measurement Techniques for Medicinal Chemistry and Nanomedicine

PMLM22 Laboratory Measurement Techniques for Medical Sciences

Career History

Designated Individual for HTA Human Tissue Research Licence , Swansea University

Public Engagements

Designated Individual for HTA Human Tissue Research Licence  , Swansea University