Institute of Life Science 2 Internal Atrium

Professor Deya Gonzalez

Professor

Biomedical Sciences

+44 (0) 1792 295384

d.gonzalez@swansea.ac.uk

Office - 210
Second Floor
Institute of Life Science 2
Singleton Campus

Available For Postgraduate Supervision

Research Links

https://orcid.org/0000-0002-1838-6752

ResearchGate

About

Deya is a Professor of Molecular Medicine, and a founding member of the Reproductive Biology and Gynaecological Oncology Group at Swansea University Medical School.
She considers herself a translational scientist in the areas of female infertility and cancer, with the ultimate goal of developing functional platforms and bringing targeted therapies into the clinic for the benefit of patients. Her projects involve close collaborations with the NHS and the private sector in the areas of multicellular 3D-patient derived models of disease and precision medicines including Antibody Drug Conjugates and Exosomes. She is a co-PI of the CEAT-Cluster for Epigenomics and ADC therapeutics project (£2.6M), where she leads the ADC programme.
Deya is also the Chair of Research Ethics & Governance at Swansea University Medical School. She serves as editorial member of several journals in the areas of reproductive medicine and oncology. Deya is the Regional non-clinical Champion for South West Wales within the Wales Cancer Research Centre.

Areas Of Expertise

• Gynaecological cancers
• 3D patient-derived models
• functional tissue and blood biomarkers
• advanced targeted therapies
• female infertility
• tumour microenvironment
• drug discovery
• inflammation

Career Highlights

Teaching Interests

Deya lectures on the Genetics, Biochemistry and Applied Medical Sciences BSc Degree programmes and on the MSc in Nanomedicine programme. She is a Fellow of The Higher Education Academy and she regularly hosts MSCi students.

Research

Publications

Research Highlights

Pan-Castillo, B., Gazze, S., Thomas, S., Lucas, C., Margarit, L., Gonzalez, D., Francis, L., Conlan, R., & Conlan, S. (2018). Morphophysical dynamics of human endometrial cells during decidualization. Nanomedicine: Nanotechnology, Biology and Medicine, 14(7), 2235-2245.
https://doi.org/10.1016/J.NANO.2018.07.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43701
Gonzalez, D., Rojas, A., Herrera, M., Conlan, R., & Conlan, S. (2012). iNOS Activation Regulates β-catenin Association with Its Partners in Endothelial Cells. PLoS ONE, 7(12), e52964
https://doi.org/10.1371/journal.pone.0052964, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13893
Younas, K., Gonzalez, D., Francis, L., White, J., Joels, L., Bunkheila, A., & Conlan, R. (2013). MAGE-11 profiling in fertile, infertile PCOS and endometriosis human endometrium. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 120, 205-205.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19716
Lucas, C., Francis, L., Gonzalez, D., & Conlan, R. (2013). The effect of the Wilms tumour suppressor protein (WT1) on regulating cellular morphology and gene expression in endometrial stromal cells. EUROPEAN JOURNAL OF CANCER, 49, S135-S136.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19715
Gonzalez, D., Thackeray, H., Lewis, P., Mantani, A., Brook, N., Ahuja, K., Margara, R., Joels, L., White, J., Conlan, R., Lewis, P., & Conlan, S. (2012). Loss of WT1 Expression in the Endometrium of Infertile PCOS Patients: A Hyperandrogenic Effect?. The Journal of Clinical Endocrinology and Metabolism, 97(3), 957-966.
https://doi.org/10.1210/jc.2011-2366, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10684
Rojas, A., Gonzalez, D., Figueroa, H., Morales, M., & Romero, J. (2010). Modulation of Nitric Oxide Pathway by Multiligands/RAGE Axis: A Crossing Point on the Road to Microvascular Complication in Diabetes. Current Enzyme Inhibition, 6(1), 34-45.
https://doi.org/10.2174/157340810790712050, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19703
Bowen, A., Gonzalez, D., Mullins, J., Bhatt, A., Martinez, A., Conlan, R., & Conlan, S. (2010). PAH-Domain-Specific Interactions of the Arabidopsis Transcription Coregulator SIN3-LIKE1 (SNL1) with Telomere-Binding Protein 1 and ALWAYS EARLY2 Myb-DNA Binding Factors. Journal of Molecular Biology, 395(5), 937-949.
https://doi.org/10.1016/j.jmb.2009.11.065, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10489
FRANCIS, L., GONZALEZ, D., RYDER, T., BAER, K., REES, M., WHITE, J., CONLAN, R., WRIGHT, C., Wright, C., Conlan, S., Gonzalez, D., Rees, M., & Francis, L. (2010). Optimized sample preparation for high-resolution AFM characterization of fixed human cells. Journal of Microscopy, 240(2), 111-121.
https://doi.org/10.1111/j.1365-2818.2010.03392.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10686
Margarit, L., Gonzalez, D., Lewis, P., Hopkins, L., Davies, C., Conlan, R., Joels, L., White, J., Lewis, P., Conlan, S., & Gonzalez, D. (2009). L-Selectin ligands in human endometrium: comparison of fertile and infertile subjects. Human Reproduction, 24(11), 2767-2777.
https://doi.org/10.1093/humrep/dep247, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10689
GARRIDO, G., GONZALEZ, D., ROMAY, C., NUNEZSELLES, A., DELGADO, R., & Gonzalez, D. (2008). Scavenger effect of a mango (Mangifera indica L.) food supplement’s active ingredient on free radicals produced by human polymorphonuclear cells and hypoxanthine–xanthine oxidase chemiluminescence systems. Food Chemistry, 107(3), 1008-1014.
https://doi.org/10.1016/j.foodchem.2007.09.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10491
Davies, D., Meade, K., Herath, S., Eckersall, P., Gonzalez, D., White, J., Conlan, R., O'Farrelly, C., Sheldon, I., Conlan, S., & Sheldon, M. (2008). Toll-like receptor and antimicrobial peptide expression in the bovine endometrium. Reproductive Biology and Endocrinology, 6(1), 53
https://doi.org/10.1186/1477-7827-6-53, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10492
Garrido, G., Gonzalez, D., Lemus, Y., Delporte, C., Delgado, R., & Gonzalez, D. (2006). Protective effects of a standard extract of Mangifera indica L. (VIMANG®) against mouse ear edemas and its inhibition of eicosanoid production in J774 murine macrophages. Phytomedicine, 13(6), 412-418.
https://doi.org/10.1016/j.phymed.2004.12.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19706
Gonzalez, D., Drapier, J., Bouton, C., & Gonzalez, D. (2004). Endogenous Nitration of Iron Regulatory Protein-1 (IRP-1) in Nitric Oxide-producing Murine Macrophages: FURTHER INSIGHT INTO THE MECHANISM OF NITRATION IN VIVO AND ITS IMPACT ON IRP-1 FUNCTIONS. Journal of Biological Chemistry, 279(41), 43345-43351.
https://doi.org/10.1074/jbc.M401889200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19709
Bouton, C., Gonzalez, D., & Drapier, J. (2004). Endogenous nitration of iron regulatory protein-1 in nitric oxide-producing macrophages. Faseb Journal, 18(8), C202-C202.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19717
GARRIDO, G., Gonzalez, D., Lemus, Y., Garcia, D., Lodeiro, L., Quintero, G., Delporte, C., Nuñez-Selles, A., & Delgado, R. (2004). In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANGS). Pharmacological Research, 50(2), 143-149.
https://doi.org/10.1016/j.phrs.2003.12.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19707
González, D., Herrera, B., Beltrán, A., Otero, K., Quintero, G., Rojas, A., & Gonzalez, D. (2003). Nitric oxide disrupts VE-cadherin complex in murine microvascular endothelial cells. Biochemical and Biophysical Research Communications, 304(1), 113-118.
https://doi.org/10.1016/S0006-291X(03)00546-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19710
Otero, K., Martinez, F., Beltran, A., Gonzalez, D., Herrera, M., & Rojas, A. (2001). Albumin-derived advanced glycation end-products trigger the disruption of the vascular endothelial cadherin complex in cultured human and murine endothelial cells. Biochem. J., 359, 567-574.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19711
Delgado, R., Garrido, G., Gonzalez, D., Herrera, M., Beltran, A., Lemus, Y., & Rodriguez, J. (2001). Mangifera indica L. extract (VIMANG) as a natural antioxidant with antinociceptive and anti-inflammatory properties. Minerva Medica, 92, 98-102.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19713
Garrido, G., Gonzalez, D., Delporte, C., Backhouse, N., Quintero, G., Nunez-Selles, A., & Morales, M. (2001). Analgesic and anti-inflammatory effects ofMangifera indica L. extract (Vimang). Phytotherapy Research, 15(1), 18-21.
https://doi.org/10.1002/1099-1573(200102)15:1<18::AID-PTR676>3.0.CO;2-R, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19708
Rojas, A., Romay, S., Gonzalez, D., Herrera, B., Delgado, R., Otero, K., & Gonzalez, D. (2000). Regulation of Endothelial Nitric Oxide Synthase Expression by Albumin-Derived Advanced Glycosylation End Products. Circulation Research, 86(3), e50-e54.
https://doi.org/10.1161/01.RES.86.3.e50, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19712
Blanco, O., Beltran, A., Gonzalez, D., Sanchez, J., Fernandez, O., Faure, R., & Delgado, R. (2000). Some anti-inflammatory properties of a natural pulmonary surfactant: Surfacen. Applied Cardiopulmonary Pathophysiology, 9(3), 201-202.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19714
Sridhar, V., Surendrarao, A., Gonzalez, D., Conlan, R., Liu, Z., Conlan, S., & Gonzalez, D. (2004). Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development. Proceedings of the National Academy of Sciences, 101(31), 11494-11499.
https://doi.org/10.1073/pnas.0403055101, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1403
Gonzalez, D., Bowen, A., Carroll, T., Conlan, R., Conlan, S., & Gonzalez, D. (2007). The Transcription Corepressor LEUNIG Interacts with the Histone Deacetylase HDA19 and Mediator Components MED14 (SWP) and CDK8 (HEN3) To Repress Transcription. Molecular and Cellular Biology, 27(15), 5306-5315.
https://doi.org/10.1128/MCB.01912-06, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1405
Margarit, L., Taylor, A., Roberts, M., Hopkins, L., Davies, C., Brenton, A., Conlan, R., Bunkheila, A., Joels, L., White, J., Gonzalez, D., Conlan, S., & Gonzalez, D. (2010). MUC1 as a Discriminator between Endometrium from Fertile and Infertile Patients with PCOS and Endometriosis. Journal of Clinical Endocrinology & Metabolism, 95(12), 5320-5329.
https://doi.org/10.1210/jc.2010-0603, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9821
Francis, L., Lewis, P., Gonzalez, D., Ryder, T., Webb, G., Joels, L., White, J., Wright, C., Conlan, R., Wright, C., & Conlan, S. (2009). Progesterone induces nano-scale molecular modifications on endometrial epithelial cell surfaces. Biology of the Cell, 101(8), 481-493.
https://doi.org/10.1042/BC20080189, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9823
Gonzalez, D., Hamidi, N., Sol, R., Benschop, J., Nancy, T., Li, C., Francis, L., Tzouros, M., Krijgsveld, J., Holstege, F., Conlan, S., & Del Sol Abascal, R. (2014). Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Proceedings of the National Academy of Sciences, 111(7), 2500-2505.
https://doi.org/10.1073/pnas.1307525111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17235
Teixeira, S., Burwell, G., Castaing, A., Gonzalez, D., Conlan, R., Guy, O., Guy, O., Conlan, S., Gonzalez, D., & Rodrigues Teixeira, S. (2014). Epitaxial graphene immunosensor for human chorionic gonadotropin. Sensors and Actuators B: Chemical, 190, 723-729.
https://doi.org/10.1016/j.snb.2013.09.019, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28115
Howard, D., Garcia-Parra, J., Healey, G., Amakiri, C., Margarit, L., Francis, L., Gonzalez, D., Conlan, R., Conlan, S., & Garcia Parra, J. (2016). Antibody–drug conjugates and other nanomedicines: the frontier of gynaecological cancer treatment. Interface Focus, 6(6), 20160054
https://doi.org/10.1098/rsfs.2016.0054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33095
Healey, G., Frostell, A., Fagge, T., Gonzalez, D., Conlan, R., & Conlan, S. (2019). A RAGE-Targeted Antibody-Drug Conjugate: Surface Plasmon Resonance as a Platform for Accelerating Effective ADC Design and Development. Antibodies, 8(1), 7
https://doi.org/10.3390/antib8010007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48095
Quintela, M., Sieglaff, D., Gazze, A., Zhang, A., Gonzalez, D., Francis, L., Webb, P., Conlan, R., & Conlan, S. (2019). HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. Nanomedicine: Nanotechnology, Biology and Medicine, 17, 254-265.
https://doi.org/10.1016/j.nano.2019.01.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48863
Pisano, S., Giustiniani, M., Francis, L., Gonzalez, D., Margarit, L., Sheldon, M., Paolino, D., Fresta, M., Sawhney, A., & Healey, G. (2019). Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract. Biomedical Microdevices, 21(2)
https://doi.org/10.1007/s10544-019-0385-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49813
Teixeira, S., Abreu, C., Parkes, L., Davies, J., Yao, S., Sawhney, M., Margarit, L., Gonzalez, D., Pinto, I., Francis, L., Conlan, R., Conlan, S., Gonzalez, D., & Francis, L. (2019). Direct monitoring of breast and endometrial cancer cell epigenetic response to DNA methyltransferase and histone deacetylase inhibitors. Biosensors and Bioelectronics, 141, 111386
https://doi.org/10.1016/j.bios.2019.111386, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50808
Younas, K., Quintela, M., Thomas, S., Garcia-Parra, J., Blake, L., Whiteland, H., Bunkheila, A., Francis, L., Margarit, L., Gonzalez, D., Conlan, S., & Francis, L. (2019). Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11. Journal of Molecular Medicine, 97(9), 1315-1327.
https://doi.org/10.1007/s00109-019-01809-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50966
Healey, G., Pan Castillo, B., Garcia Parra, J., Davies, J., Roberts, S., Jones, E., Dhar, K., Nandanan, S., Tofazzal, N., Piggott, L., Clarkson, R., Seaton, G., Frostell, A., Fagge, T., McKee, C., Margarit, L., Conlan, S., & Gonzalez, D. (2019). Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer. Journal for ImmunoTherapy of Cancer, 7(1)
https://doi.org/10.1186/s40425-019-0765-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52619
Paradiso, F., Fitzgerald, J., Yao, S., Barry, F., Taraballi, F., Gonzalez, D., Conlan, S., & Francis, L. (2019). Marine Collagen Substrates for 2D and 3D Ovarian Cancer Cell Systems. Frontiers in Bioengineering and Biotechnology, 7
https://doi.org/10.3389/fbioe.2019.00343, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52699
Abreu, C., Thomas, V., Knaggs, P., Bunkheila, A., Cruz, A., Rodrigues Teixeira, S., Alpuim, P., Francis, L., Gebril, A., Ibrahim, A., Margarit, L., Gonzalez, D., Freitas, P., Conlan, S., & Pinto, I. (2020). Non-invasive molecular assessment of human embryo development and implantation potential. Biosensors and Bioelectronics, 157, 112144
https://doi.org/10.1016/j.bios.2020.112144, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53819
Toubhans, B., Gazze, S., Bissardon, C., Bohic, S., Gourlan, A., Gonzalez, D., Charlet, L., Conlan, S., & Francis, L. (2020). Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics. Nanomedicine: Nanotechnology, Biology and Medicine, 29, 102258
https://doi.org/10.1016/j.nano.2020.102258, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54635
Toubhans, B., Gourlan, A., Telouk, P., Lutchman-Singh, K., Francis, L., Conlan, S., Margarit, L., Gonzalez, D., & Charlet, L. (2020). Cu isotope ratios are meaningful in ovarian cancer diagnosis. Journal of Trace Elements in Medicine and Biology, 62, 126611
https://doi.org/10.1016/j.jtemb.2020.126611, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54643
Coombes, Z., Yadav, V., McCoubrey, L., Freire, C., Basit, A., Conlan, S., & Gonzalez, D. (2020). Progestogens Are Metabolized by the Gut Microbiota: Implications for Colonic Drug Delivery. Pharmaceutics, 12(8), 760
https://doi.org/10.3390/pharmaceutics12080760, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55037
Paravati, R., De Mello, N., Onyido, E., Francis, L., Bruesehafer, K., Younas, K., Spencer-Harty, S., Conlan, S., Gonzalez, D., & Margarit, L. (2020). Differential regulation of osteopontin and CD44 correlates with infertility status in PCOS patients. Journal of Molecular Medicine, 98
https://doi.org/10.1007/s00109-020-01985-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55414
Pisano, S., Wang, X., Garcia Parra, J., Gazze, S., Edwards, K., Feltracco, V., Hu, Y., He, L., Gonzalez, D., Francis, L., Conlan, S., & Li, C. (2020). Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro. Cancer Nanotechnology, 11(1)
https://doi.org/10.1186/s12645-020-00070-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55789
Francis, L., Yao, S., Powell, L., Griffiths, S., Berquand, A., Piasecki, T., Howe, W., Gazze, A., Farach-Carson, M., Constantinou, P., Carson, D., Margarit, L., Gonzalez, D., & Conlan, S. (2021). Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00793-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56223
Gazze, S., Thomas, S., Garcia-Parra, J., James, D., Rees, P., Marsh-Durban, V., Corteling, R., Gonzalez, D., Conlan, S., & Francis, L. (2021). High content, quantitative AFM analysis of the scalable biomechanical properties of extracellular vesicles. Nanoscale, 13(12), 6129-6141.
https://doi.org/10.1039/d0nr09235e, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56477
Howard, D., James, D., Murphy, K., Garcia Parra, J., Pan Castillo, B., Rex, S., Moul, A., Jones, E., Bilbao Asensio, M., Michue-Seijas, S., Lutchman-Singh, K., Margarit, L., Francis, L., Rees, P., Gonzalez, D., & Conlan, S. (2021). Dinaciclib, a Bimodal Agent Effective against Endometrial Cancer. Cancers, 13(5), 1135
https://doi.org/10.3390/cancers13051135, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56783
Edwards, K., Yao, S., Pisano, S., Feltracco, V., Bruesehafer, K., Samanta, S., Oommen, O., Gazze, S., Paravati, R., Maddison, H., Li, C., Gonzalez, D., Conlan, S., & Francis, L. (2021). Hyaluronic Acid-Functionalized Nanomicelles Enhance SAHA Efficacy in 3D Endometrial Cancer Models. Cancers, 13(16), 4032
https://doi.org/10.3390/cancers13164032, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57595
Khan, Z., Healey, G., Paravati, R., Berry, N., Rees, E., Margarit, L., Gonzalez, D., Emery, S., & Conlan, S. (2021). Chronic Urinary Infection in Overactive Bladder Syndrome: A Prospective, Blinded Case Control Study. Frontiers in Cellular and Infection Microbiology, 11
https://doi.org/10.3389/fcimb.2021.752275, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58079
Pisano, S., Lenna, S., Healey, G., Izardi, F., Meeks, L., Jimenez, Y., Velazquez, O., Gonzalez, D., Conlan, S., & Corradetti, B. (2021). Assessment of the immune landscapes of advanced ovarian cancer in an optimized in vivo model. Clinical and Translational Medicine, 11(10)
https://doi.org/10.1002/ctm2.551, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58302
Coombes, Z., Plant, K., Freire, C., Basit, A., Butler, P., Conlan, S., & Gonzalez, D. (2021). Progesterone Metabolism by Human and Rat Hepatic and Intestinal Tissue. Pharmaceutics, 13(10), 1707
https://doi.org/10.3390/pharmaceutics13101707, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58361
Howard, D., James, D., Garcia Parra, J., Pan Castillo, B., Worthington, J., Williams, N., Bentham, Z., Rees, S., Lutchman-Singh, K., Francis, L., Rees, P., Margarit, L., Conlan, S., & Gonzalez, D. (2022). Dinaciclib as an effective pan-cyclin dependent kinase inhibitor in platinum resistant ovarian cancer. Frontiers in Oncology, 12
https://doi.org/10.3389/fonc.2022.1014280, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61957
TOUBHANS, B., Alkafri, N., Quintela Vazquez, M., James, D., Bissardon, C., Gazze, S., Knodel, F., Proux, O., Gourlan, A., Rathert, P., Bohic, S., Gonzalez, D., Francis, L., Charlet, L., & Conlan, S. (2023). Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion. Redox Biology, 61, 102641
https://doi.org/10.1016/j.redox.2023.102641, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62755
Onyido, E., James, D., Garcia-Parra, J., Sinfield, J., Moberg, A., Coombes, Z., Worthington, J., Williams, N., Francis, L., Conlan, S., & Gonzalez, D. (2023). Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity. Antibodies, 12(4), 65
https://doi.org/10.3390/antib12040065, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65401
James, D., Quintela Vazquez, M., Lucini, L., Al Kafri, N., Healey, G., Jones, N., Younas, K., Bunkheila, A., Margarit, L., Francis, L., Gonzalez, D., & Conlan, S. (2024). Homeobox regulator Wilms Tumour 1 is displaced by androgen receptor at cis-regulatory elements in the endometrium of PCOS patients. Frontiers in Endocrinology, 15
https://doi.org/10.3389/fendo.2024.1368494, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66500
Williams, M., Howard, D., Donnelly, C., Izadi, F., Garcia Parra, J., Pugh, M., EDWARDS, K., Lutchman-Sigh, K., Jones, S., Margarit, L., Francis, L., Conlan, S., Taraballi, F., & Gonzalez, D. (2024). Adipocyte derived exosomes promote cell invasion and challenge paclitaxel efficacy in ovarian cancer. Cell Communication and Signaling, 22(1)
https://doi.org/10.1186/s12964-024-01806-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67596

All Research

Journal Articles

Williams, M., Howard, D., Donnelly, C., Izadi, F., Garcia Parra, J., Pugh, M., EDWARDS, K., Lutchman-Sigh, K., Jones, S., Margarit, L., Francis, L., Conlan, S., Taraballi, F., & Gonzalez, D. (2024). Adipocyte derived exosomes promote cell invasion and challenge paclitaxel efficacy in ovarian cancer. Cell Communication and Signaling, 22(1)
https://doi.org/10.1186/s12964-024-01806-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67596
James, D., Quintela Vazquez, M., Lucini, L., Al Kafri, N., Healey, G., Jones, N., Younas, K., Bunkheila, A., Margarit, L., Francis, L., Gonzalez, D., & Conlan, S. (2024). Homeobox regulator Wilms Tumour 1 is displaced by androgen receptor at cis-regulatory elements in the endometrium of PCOS patients. Frontiers in Endocrinology, 15
https://doi.org/10.3389/fendo.2024.1368494, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66500
Onyido, E., James, D., Garcia-Parra, J., Sinfield, J., Moberg, A., Coombes, Z., Worthington, J., Williams, N., Francis, L., Conlan, S., & Gonzalez, D. (2023). Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity. Antibodies, 12(4), 65
https://doi.org/10.3390/antib12040065, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65401
TOUBHANS, B., Alkafri, N., Quintela Vazquez, M., James, D., Bissardon, C., Gazze, S., Knodel, F., Proux, O., Gourlan, A., Rathert, P., Bohic, S., Gonzalez, D., Francis, L., Charlet, L., & Conlan, S. (2023). Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion. Redox Biology, 61, 102641
https://doi.org/10.1016/j.redox.2023.102641, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62755
Howard, D., James, D., Garcia Parra, J., Pan Castillo, B., Worthington, J., Williams, N., Bentham, Z., Rees, S., Lutchman-Singh, K., Francis, L., Rees, P., Margarit, L., Conlan, S., & Gonzalez, D. (2022). Dinaciclib as an effective pan-cyclin dependent kinase inhibitor in platinum resistant ovarian cancer. Frontiers in Oncology, 12
https://doi.org/10.3389/fonc.2022.1014280, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61957
Coombes, Z., Plant, K., Freire, C., Basit, A., Butler, P., Conlan, S., & Gonzalez, D. (2021). Progesterone Metabolism by Human and Rat Hepatic and Intestinal Tissue. Pharmaceutics, 13(10), 1707
https://doi.org/10.3390/pharmaceutics13101707, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58361
Pisano, S., Lenna, S., Healey, G., Izardi, F., Meeks, L., Jimenez, Y., Velazquez, O., Gonzalez, D., Conlan, S., & Corradetti, B. (2021). Assessment of the immune landscapes of advanced ovarian cancer in an optimized in vivo model. Clinical and Translational Medicine, 11(10)
https://doi.org/10.1002/ctm2.551, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58302
Khan, Z., Healey, G., Paravati, R., Berry, N., Rees, E., Margarit, L., Gonzalez, D., Emery, S., & Conlan, S. (2021). Chronic Urinary Infection in Overactive Bladder Syndrome: A Prospective, Blinded Case Control Study. Frontiers in Cellular and Infection Microbiology, 11
https://doi.org/10.3389/fcimb.2021.752275, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58079
Edwards, K., Yao, S., Pisano, S., Feltracco, V., Bruesehafer, K., Samanta, S., Oommen, O., Gazze, S., Paravati, R., Maddison, H., Li, C., Gonzalez, D., Conlan, S., & Francis, L. (2021). Hyaluronic Acid-Functionalized Nanomicelles Enhance SAHA Efficacy in 3D Endometrial Cancer Models. Cancers, 13(16), 4032
https://doi.org/10.3390/cancers13164032, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57595
Gazze, S., Thomas, S., Garcia-Parra, J., James, D., Rees, P., Marsh-Durban, V., Corteling, R., Gonzalez, D., Conlan, S., & Francis, L. (2021). High content, quantitative AFM analysis of the scalable biomechanical properties of extracellular vesicles. Nanoscale, 13(12), 6129-6141.
https://doi.org/10.1039/d0nr09235e, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56477
Howard, D., James, D., Murphy, K., Garcia Parra, J., Pan Castillo, B., Rex, S., Moul, A., Jones, E., Bilbao Asensio, M., Michue-Seijas, S., Lutchman-Singh, K., Margarit, L., Francis, L., Rees, P., Gonzalez, D., & Conlan, S. (2021). Dinaciclib, a Bimodal Agent Effective against Endometrial Cancer. Cancers, 13(5), 1135
https://doi.org/10.3390/cancers13051135, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56783
Francis, L., Yao, S., Powell, L., Griffiths, S., Berquand, A., Piasecki, T., Howe, W., Gazze, A., Farach-Carson, M., Constantinou, P., Carson, D., Margarit, L., Gonzalez, D., & Conlan, S. (2021). Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00793-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56223
Toubhans, B., Gourlan, A., Telouk, P., Lutchman-Singh, K., Francis, L., Conlan, S., Margarit, L., Gonzalez, D., & Charlet, L. (2020). Cu isotope ratios are meaningful in ovarian cancer diagnosis. Journal of Trace Elements in Medicine and Biology, 62, 126611
https://doi.org/10.1016/j.jtemb.2020.126611, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54643
Pisano, S., Wang, X., Garcia Parra, J., Gazze, S., Edwards, K., Feltracco, V., Hu, Y., He, L., Gonzalez, D., Francis, L., Conlan, S., & Li, C. (2020). Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro. Cancer Nanotechnology, 11(1)
https://doi.org/10.1186/s12645-020-00070-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55789
Paravati, R., De Mello, N., Onyido, E., Francis, L., Bruesehafer, K., Younas, K., Spencer-Harty, S., Conlan, S., Gonzalez, D., & Margarit, L. (2020). Differential regulation of osteopontin and CD44 correlates with infertility status in PCOS patients. Journal of Molecular Medicine, 98
https://doi.org/10.1007/s00109-020-01985-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55414
Toubhans, B., Gazze, S., Bissardon, C., Bohic, S., Gourlan, A., Gonzalez, D., Charlet, L., Conlan, S., & Francis, L. (2020). Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics. Nanomedicine: Nanotechnology, Biology and Medicine, 29, 102258
https://doi.org/10.1016/j.nano.2020.102258, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54635
Coombes, Z., Yadav, V., McCoubrey, L., Freire, C., Basit, A., Conlan, S., & Gonzalez, D. (2020). Progestogens Are Metabolized by the Gut Microbiota: Implications for Colonic Drug Delivery. Pharmaceutics, 12(8), 760
https://doi.org/10.3390/pharmaceutics12080760, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55037
Abreu, C., Thomas, V., Knaggs, P., Bunkheila, A., Cruz, A., Rodrigues Teixeira, S., Alpuim, P., Francis, L., Gebril, A., Ibrahim, A., Margarit, L., Gonzalez, D., Freitas, P., Conlan, S., & Pinto, I. (2020). Non-invasive molecular assessment of human embryo development and implantation potential. Biosensors and Bioelectronics, 157, 112144
https://doi.org/10.1016/j.bios.2020.112144, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53819
Paradiso, F., Fitzgerald, J., Yao, S., Barry, F., Taraballi, F., Gonzalez, D., Conlan, S., & Francis, L. (2019). Marine Collagen Substrates for 2D and 3D Ovarian Cancer Cell Systems. Frontiers in Bioengineering and Biotechnology, 7
https://doi.org/10.3389/fbioe.2019.00343, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52699
Healey, G., Pan Castillo, B., Garcia Parra, J., Davies, J., Roberts, S., Jones, E., Dhar, K., Nandanan, S., Tofazzal, N., Piggott, L., Clarkson, R., Seaton, G., Frostell, A., Fagge, T., McKee, C., Margarit, L., Conlan, S., & Gonzalez, D. (2019). Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer. Journal for ImmunoTherapy of Cancer, 7(1)
https://doi.org/10.1186/s40425-019-0765-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52619
Teixeira, S., Abreu, C., Parkes, L., Davies, J., Yao, S., Sawhney, M., Margarit, L., Gonzalez, D., Pinto, I., Francis, L., Conlan, R., Conlan, S., Gonzalez, D., & Francis, L. (2019). Direct monitoring of breast and endometrial cancer cell epigenetic response to DNA methyltransferase and histone deacetylase inhibitors. Biosensors and Bioelectronics, 141, 111386
https://doi.org/10.1016/j.bios.2019.111386, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50808
Younas, K., Quintela, M., Thomas, S., Garcia-Parra, J., Blake, L., Whiteland, H., Bunkheila, A., Francis, L., Margarit, L., Gonzalez, D., Conlan, S., & Francis, L. (2019). Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11. Journal of Molecular Medicine, 97(9), 1315-1327.
https://doi.org/10.1007/s00109-019-01809-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50966
Pisano, S., Giustiniani, M., Francis, L., Gonzalez, D., Margarit, L., Sheldon, M., Paolino, D., Fresta, M., Sawhney, A., & Healey, G. (2019). Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract. Biomedical Microdevices, 21(2)
https://doi.org/10.1007/s10544-019-0385-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49813
Quintela, M., Sieglaff, D., Gazze, A., Zhang, A., Gonzalez, D., Francis, L., Webb, P., Conlan, R., & Conlan, S. (2019). HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. Nanomedicine: Nanotechnology, Biology and Medicine, 17, 254-265.
https://doi.org/10.1016/j.nano.2019.01.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48863
Healey, G., Frostell, A., Fagge, T., Gonzalez, D., Conlan, R., & Conlan, S. (2019). A RAGE-Targeted Antibody-Drug Conjugate: Surface Plasmon Resonance as a Platform for Accelerating Effective ADC Design and Development. Antibodies, 8(1), 7
https://doi.org/10.3390/antib8010007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48095
Pan-Castillo, B., Gazze, S., Thomas, S., Lucas, C., Margarit, L., Gonzalez, D., Francis, L., Conlan, R., & Conlan, S. (2018). Morphophysical dynamics of human endometrial cells during decidualization. Nanomedicine: Nanotechnology, Biology and Medicine, 14(7), 2235-2245.
https://doi.org/10.1016/J.NANO.2018.07.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43701
Howard, D., Garcia-Parra, J., Healey, G., Amakiri, C., Margarit, L., Francis, L., Gonzalez, D., Conlan, R., Conlan, S., & Garcia Parra, J. (2016). Antibody–drug conjugates and other nanomedicines: the frontier of gynaecological cancer treatment. Interface Focus, 6(6), 20160054
https://doi.org/10.1098/rsfs.2016.0054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33095
Gonzalez, D., Hamidi, N., Sol, R., Benschop, J., Nancy, T., Li, C., Francis, L., Tzouros, M., Krijgsveld, J., Holstege, F., Conlan, S., & Del Sol Abascal, R. (2014). Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Proceedings of the National Academy of Sciences, 111(7), 2500-2505.
https://doi.org/10.1073/pnas.1307525111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17235
Teixeira, S., Burwell, G., Castaing, A., Gonzalez, D., Conlan, R., Guy, O., Guy, O., Conlan, S., Gonzalez, D., & Rodrigues Teixeira, S. (2014). Epitaxial graphene immunosensor for human chorionic gonadotropin. Sensors and Actuators B: Chemical, 190, 723-729.
https://doi.org/10.1016/j.snb.2013.09.019, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28115
Younas, K., Gonzalez, D., Francis, L., White, J., Joels, L., Bunkheila, A., & Conlan, R. (2013). MAGE-11 profiling in fertile, infertile PCOS and endometriosis human endometrium. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 120, 205-205.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19716
Lucas, C., Francis, L., Gonzalez, D., & Conlan, R. (2013). The effect of the Wilms tumour suppressor protein (WT1) on regulating cellular morphology and gene expression in endometrial stromal cells. EUROPEAN JOURNAL OF CANCER, 49, S135-S136.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19715
Gonzalez, D., Rojas, A., Herrera, M., Conlan, R., & Conlan, S. (2012). iNOS Activation Regulates β-catenin Association with Its Partners in Endothelial Cells. PLoS ONE, 7(12), e52964
https://doi.org/10.1371/journal.pone.0052964, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13893
Gonzalez, D., Thackeray, H., Lewis, P., Mantani, A., Brook, N., Ahuja, K., Margara, R., Joels, L., White, J., Conlan, R., Lewis, P., & Conlan, S. (2012). Loss of WT1 Expression in the Endometrium of Infertile PCOS Patients: A Hyperandrogenic Effect?. The Journal of Clinical Endocrinology and Metabolism, 97(3), 957-966.
https://doi.org/10.1210/jc.2011-2366, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10684
Rojas, A., Gonzalez, D., Figueroa, H., Morales, M., & Romero, J. (2010). Modulation of Nitric Oxide Pathway by Multiligands/RAGE Axis: A Crossing Point on the Road to Microvascular Complication in Diabetes. Current Enzyme Inhibition, 6(1), 34-45.
https://doi.org/10.2174/157340810790712050, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19703
Bowen, A., Gonzalez, D., Mullins, J., Bhatt, A., Martinez, A., Conlan, R., & Conlan, S. (2010). PAH-Domain-Specific Interactions of the Arabidopsis Transcription Coregulator SIN3-LIKE1 (SNL1) with Telomere-Binding Protein 1 and ALWAYS EARLY2 Myb-DNA Binding Factors. Journal of Molecular Biology, 395(5), 937-949.
https://doi.org/10.1016/j.jmb.2009.11.065, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10489
Margarit, L., Taylor, A., Roberts, M., Hopkins, L., Davies, C., Brenton, A., Conlan, R., Bunkheila, A., Joels, L., White, J., Gonzalez, D., Conlan, S., & Gonzalez, D. (2010). MUC1 as a Discriminator between Endometrium from Fertile and Infertile Patients with PCOS and Endometriosis. Journal of Clinical Endocrinology & Metabolism, 95(12), 5320-5329.
https://doi.org/10.1210/jc.2010-0603, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9821
FRANCIS, L., GONZALEZ, D., RYDER, T., BAER, K., REES, M., WHITE, J., CONLAN, R., WRIGHT, C., Wright, C., Conlan, S., Gonzalez, D., Rees, M., & Francis, L. (2010). Optimized sample preparation for high-resolution AFM characterization of fixed human cells. Journal of Microscopy, 240(2), 111-121.
https://doi.org/10.1111/j.1365-2818.2010.03392.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10686
Margarit, L., Gonzalez, D., Lewis, P., Hopkins, L., Davies, C., Conlan, R., Joels, L., White, J., Lewis, P., Conlan, S., & Gonzalez, D. (2009). L-Selectin ligands in human endometrium: comparison of fertile and infertile subjects. Human Reproduction, 24(11), 2767-2777.
https://doi.org/10.1093/humrep/dep247, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10689
Francis, L., Lewis, P., Gonzalez, D., Ryder, T., Webb, G., Joels, L., White, J., Wright, C., Conlan, R., Wright, C., & Conlan, S. (2009). Progesterone induces nano-scale molecular modifications on endometrial epithelial cell surfaces. Biology of the Cell, 101(8), 481-493.
https://doi.org/10.1042/BC20080189, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9823
GARRIDO, G., GONZALEZ, D., ROMAY, C., NUNEZSELLES, A., DELGADO, R., & Gonzalez, D. (2008). Scavenger effect of a mango (Mangifera indica L.) food supplement’s active ingredient on free radicals produced by human polymorphonuclear cells and hypoxanthine–xanthine oxidase chemiluminescence systems. Food Chemistry, 107(3), 1008-1014.
https://doi.org/10.1016/j.foodchem.2007.09.012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10491
Davies, D., Meade, K., Herath, S., Eckersall, P., Gonzalez, D., White, J., Conlan, R., O'Farrelly, C., Sheldon, I., Conlan, S., & Sheldon, M. (2008). Toll-like receptor and antimicrobial peptide expression in the bovine endometrium. Reproductive Biology and Endocrinology, 6(1), 53
https://doi.org/10.1186/1477-7827-6-53, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10492
Gonzalez, D., Bowen, A., Carroll, T., Conlan, R., Conlan, S., & Gonzalez, D. (2007). The Transcription Corepressor LEUNIG Interacts with the Histone Deacetylase HDA19 and Mediator Components MED14 (SWP) and CDK8 (HEN3) To Repress Transcription. Molecular and Cellular Biology, 27(15), 5306-5315.
https://doi.org/10.1128/MCB.01912-06, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1405
Garrido, G., Gonzalez, D., Lemus, Y., Delporte, C., Delgado, R., & Gonzalez, D. (2006). Protective effects of a standard extract of Mangifera indica L. (VIMANG®) against mouse ear edemas and its inhibition of eicosanoid production in J774 murine macrophages. Phytomedicine, 13(6), 412-418.
https://doi.org/10.1016/j.phymed.2004.12.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19706
Gonzalez, D., Drapier, J., Bouton, C., & Gonzalez, D. (2004). Endogenous Nitration of Iron Regulatory Protein-1 (IRP-1) in Nitric Oxide-producing Murine Macrophages: FURTHER INSIGHT INTO THE MECHANISM OF NITRATION IN VIVO AND ITS IMPACT ON IRP-1 FUNCTIONS. Journal of Biological Chemistry, 279(41), 43345-43351.
https://doi.org/10.1074/jbc.M401889200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19709
Bouton, C., Gonzalez, D., & Drapier, J. (2004). Endogenous nitration of iron regulatory protein-1 in nitric oxide-producing macrophages. Faseb Journal, 18(8), C202-C202.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19717
GARRIDO, G., Gonzalez, D., Lemus, Y., Garcia, D., Lodeiro, L., Quintero, G., Delporte, C., Nuñez-Selles, A., & Delgado, R. (2004). In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANGS). Pharmacological Research, 50(2), 143-149.
https://doi.org/10.1016/j.phrs.2003.12.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19707
Sridhar, V., Surendrarao, A., Gonzalez, D., Conlan, R., Liu, Z., Conlan, S., & Gonzalez, D. (2004). Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development. Proceedings of the National Academy of Sciences, 101(31), 11494-11499.
https://doi.org/10.1073/pnas.0403055101, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1403
González, D., Herrera, B., Beltrán, A., Otero, K., Quintero, G., Rojas, A., & Gonzalez, D. (2003). Nitric oxide disrupts VE-cadherin complex in murine microvascular endothelial cells. Biochemical and Biophysical Research Communications, 304(1), 113-118.
https://doi.org/10.1016/S0006-291X(03)00546-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19710
Otero, K., Martinez, F., Beltran, A., Gonzalez, D., Herrera, M., & Rojas, A. (2001). Albumin-derived advanced glycation end-products trigger the disruption of the vascular endothelial cadherin complex in cultured human and murine endothelial cells. Biochem. J., 359, 567-574.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19711
Delgado, R., Garrido, G., Gonzalez, D., Herrera, M., Beltran, A., Lemus, Y., & Rodriguez, J. (2001). Mangifera indica L. extract (VIMANG) as a natural antioxidant with antinociceptive and anti-inflammatory properties. Minerva Medica, 92, 98-102.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19713
Garrido, G., Gonzalez, D., Delporte, C., Backhouse, N., Quintero, G., Nunez-Selles, A., & Morales, M. (2001). Analgesic and anti-inflammatory effects ofMangifera indica L. extract (Vimang). Phytotherapy Research, 15(1), 18-21.
https://doi.org/10.1002/1099-1573(200102)15:1<18::AID-PTR676>3.0.CO;2-R, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19708
Rojas, A., Romay, S., Gonzalez, D., Herrera, B., Delgado, R., Otero, K., & Gonzalez, D. (2000). Regulation of Endothelial Nitric Oxide Synthase Expression by Albumin-Derived Advanced Glycosylation End Products. Circulation Research, 86(3), e50-e54.
https://doi.org/10.1161/01.RES.86.3.e50, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19712
Blanco, O., Beltran, A., Gonzalez, D., Sanchez, J., Fernandez, O., Faure, R., & Delgado, R. (2000). Some anti-inflammatory properties of a natural pulmonary surfactant: Surfacen. Applied Cardiopulmonary Pathophysiology, 9(3), 201-202.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19714

Supervision

Development of functional genomics approaches for gynaecological pathologies (current)

PhD

Other supervisor: Prof Steve Conlan
Enhancing the ADCs efficacy in the ovarian cancer tumour micro-environment (current)

PhD

Other supervisor: Prof Steve Conlan
Targeting Ferroptosis in Tuberous Sclerosis cell line models (current)

PhD

Other supervisor: Prof Steve Conlan
Therapeutic opportunities to tackle Ovarian Cancer Chemoresistance: addressing the Crosstalk between Adipocytes and tumours. (current)

PhD

Other supervisor: Prof Steve Conlan
Mathematical Modelling of Cancer-Adipocyte Interactions in Ovarian Cancer (current)

PhD

Other supervisor: Dr Noemi Picco

Other supervisor: Prof Gibin Powathil
Pharmaceutical manipulation of the SUV39H2-LSD1 regulatory pathway in ovarian cancer. (current)

PhD

Other supervisor: Prof Steve Conlan
The Role of Adipocytes in the Ovarian Cancer Metastatic Niche (awarded 2024)

PhD

Other supervisor: Prof Steve Conlan
Therapeutic exosomes as novel treatment for ovarian cancer (awarded 2022)

PhD

Other supervisor: Prof Steve Conlan
Endometriosis Signalling Pathways Mediating Aggressive Disease (current)

MSc

Other supervisor: Prof Steve Conlan
High-Grade Serous Ovarian Cancer Drug Development: Investigating the mechanism of action of PLK1 and BRD4 inhibitors in HGSOC (awarded 2024)

MSc

Other supervisor: Prof Lewis Francis

Taught Modules

PM-130 Fundamental Research Skills

This module is designed to develop the skills required for students of biochemistry and genetics degree programmes. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
PM-132 Eukaryotic Cell Biology

This module will provide students with a broad introduction to fundamental concepts in Eukaryotic cell biology, such as investigating the origins of the cell, the structure or eukaryotic cells, the different types of specialised cells, and cells which help prevent disease. There will be a general focus on human cells throughout the module with some references to other organisms when needed. Students will gain practical experience in identification and differentiation of cells from different human and animal species.
PM-132C Bioleg Celloedd Ewcaryotig

Bydd y modiwl hwn yn darparu cyflwyniad bras i gysyniadau sylfaenol ym maes bioleg celloedd Ewcaryotig, gan ymchwilio i darddiad y gell, strwythur y gell a chelloedd arbenigol a chelloedd mewn clefyd. Bydd ffocws cyffredinol ar gelloedd dynol drwy gydol y modiwl, gan gyfeirio at organebau eraill yn ôl yr angen. Bydd myfyrwyr yn cael profiad ymarferol o nodi celloedd, gwahaniaethu rhwng gwahanol gelloedd dynol a rhywogaethau o anifeiliaid.
PM-243 Clinical Biochemistry & Physiology

The module begins with a discussion of selected metabolic disorders of carbohydrate metabolism and their pathological consequences with particular emphasis on diabetes mellitus. The molecular mechanisms underlying polycystic ovarian syndrome are then considered. Next, there will be a discussion of the analytical tests used by the NHS to diagnose and monitor diseases such as diabetes (for instance the glycated haemoglobin or Hba1c test) how the test(s) can be affected by haemoglobinopathies and the length of time that has elapsed since someone has taken their medication. Finally the module reviews mechanisms of protein transport and their relevance to storage diseases.
PM-280 Skills for Researchers

The modern scientist graduate is expected to have gained extensive laboratory-based experience and this is certainly essential for any student intent on pursuing a research-based career. Skills for Researchers provides students with the opportunity to acquire the core skills to be able to conduct, analyse, interpret and present scientific experiments. A proportion of the module will be spent in the laboratory gaining hands-on experience. Skills acquired in this module will form the basis for future experimental work, including the final year project. Students will have the opportunity to provide feedback to peers and engage with a variety of online learning materials.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-352 Reproductive Biology and Medicine

This module is designed to provide students with knowledge of the biochemistry, physiology and pathology of human pregnancy, fetal development, parturition and menopause. Particular focus will be given to fertility treatments and pharmacological interventions of menopause. Lectures will cover a recap of endocrinology of reproduction, and provide details of assisted reproductive technologies. Lectures will be supported by case studies which include current clinical approaches used to treat infertility (both male and female) and menopause.
PMNM11 Nanomedicines, pharmaceuticals and advanced therapeutics

This module will explore the history and development of molecular medicines and pharmaceuticals, providing the basis for an advanced understanding of next generation therapeutic approaches. Using landmark technology and chemical development phases informed by separation science and mass spectrometry, the module uses an application driven approach to provide the student with an extensive knowledgebase of drug development, the pharmaceutical industry and nanotherapeutics. Students will be able to characterize and map the path of a drug from administration, to metabolism and elimination, and critically evaluate drug design and delivery approaches. Traditional small chemical entities used in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. Common target oncology and non-oncology disorders will provide the context; with students encouraged to explore targeted nanoparticle fabrication, drug encapsulation and release profiling, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems. Future molecular medicines such as antibody drug conjugates and kinase inhibitors will be taught by guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.
PMNM12 Research Innovation and Management

The growth of the personalised medicine industry and advances within medicine and engineering that have led to the emergence of nanomedicine, present exciting opportunities for the development of advanced therapeutics. However, the management of research and innovation from discovery through to the transition to clinical trial, present unique project management, regulatory and ethical challenges that must be considered to effectively develop new diagnostics and therapeutics. This module will take students through the development process for a novel nanomedicine, highlighting the project management, ethical and regulatory considerations at each stage. The module will also explore the challenges faced from an academic and industry perspective, as well as providing the opportunity for students to learn from industry leaders with direct experience of the research and innovation journey.
PMZM13 Diagnostics and Imaging

Nanotechnology may lead to more rapid diagnostic tests, implantable devices, point of care instruments and improved medical imaging. This module will explore the application of nanotechnology to various medical techniques, focussing on novel research devices, pre-clinical tools and emerging technology within hospitals.

Public Engagements

Soapbox science
Tenovus
Endometriosis Swansea Group