Yr Athro Thomas Wilkinson

Athro

Biomedical Sciences

t.s.wilkinson@abertawe.ac.uk

Siaradwr Cymraeg Rhugl

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0003-0397-6079

Trosolwg

Mae gan Dr Wilkinson brofiad helaeth ym maes rhyngweithiadau rhwng organebau lletyol a phathogenau, gan ddefnyddio modelu in vitro mewn celloedd epithelaidd, modelau gwaed cyfan ac anifeiliaid. Mae Dr Wilkinson yn gweithio i adnabod marcwyr defnyddiol a fydd yn helpu i ragfynegi ffactorau risg mewn perthynas â datblygu heintiau difrifol mewn pobl ac anifeiliaid. Mae ganddo dros 40 o gyhoeddiadau ym maes organebau lletyol a phathogenau, yn amrywio o fodelu ar sail meithriniad celloedd in vitro a modelau arbrofol in vivo i fodelu gwaed cyfan ex vivo. Mae wedi sicrhau cyllid grant cystadleuol gwerth dros £2 filiwn. Mae'n Athro Cysylltiol ac mae'n arwain y grŵp Microbioleg a Chlefydau Heintus ym Mhrifysgol Abertawe. Cyn symud i Abertawe (2008). bu'n Ymchwilydd Ôl-ddoethurol yng Nghaeredin (2004-2008) yng Nghanolfan y Cyngor Ymchwil Meddygol ar gyfer Ymchwil Llid ac yn Seattle yn Sefydliad Hope Heart (2001-2004) lle bu'n gweithio ar effeithiau llidus y

matrics allgellog. Enillodd Dr Wilkinson BSc mewn Ffarmacoleg gan Brifysgol Caerfaddon (1997), a PhD gan Brifysgol Cymru (2001).

Meysydd Arbenigedd

Rhyngweithiadau rhwng organebau lletyol a phathogenau
Biofarcwyr diagnostig newydd
Imiwnedd i facteria
Imiwnedd rhwystrol a chelloedd epithelaidd
Heintiau ymledol
Staphylococcus epidermidis ac S. aureus
Rhywogaethau Escherichia coli a Campylob

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Mae Dr Wilkinson yn cyfrannu at fodiwlau israddedig niferus, sy'n amlygu ei arbenigedd a'i ddiddordebau ym meysydd bioleg celloedd, imiwnoleg, clefydau heintus a rôl y microbiom mewn rhyngweithiadau rhwng organebau lletyol a phathogenau. Mae Dr Wilkinson bellach yn oruchwyliwr ôl-raddedig profiadol. Mae wedi cefnogi nifer o brosiectau i gael eu cwblhau'n llwyddiannus, ar lefel MSc drwy Ymchwil a PhD. Mae hefyd wedi arholi graddau ôl-raddedig yn fewnol yn Abertawe ac yn allanol ledled y DU.

Ymchwil Prif Wobrau Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Hilliard, G., Wilkinson, T., Harris, L., Jenkins, R., & Shornick, L. (2024). PCL-gelatin honey scaffolds promote Staphylococcus aureus agrA expression in biofilms with Pseudomonas aeruginosa. Frontiers in Microbiology, 15
https://doi.org/10.3389/fmicb.2024.1440658, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67500
Azizova, L., Dalaty, A., Brousseau, E., Birchall, J., Wilkinson, T., Sloan, A., & Ayre, W. (2024). Antimicrobial release from a lipid bilayer titanium implant coating is triggered by Staphylococcus aureus alpha-haemolysin. Applied Surface Science, 665, 160337
https://doi.org/10.1016/j.apsusc.2024.160337, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66603
Chick, H., Rees, M., Lewis, M., Williams, L., Bodger, O., Harris, L., Rushton, S., & Wilkinson, T. (2024). Using the Traditional Ex Vivo Whole Blood Model to Discriminate Bacteria by Their Inducible Host Responses. Biomedicines, 12(4), 724
https://doi.org/10.3390/biomedicines12040724, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65918
Brown, S., Evans, S., Burgum, M., Meldrum, K., Herridge, J., Akinbola, B., Harris, L., Jenkins, R., Doak, S., Clift, M., & Wilkinson, T. (2024). An In Vitro Model to Assess Early Immune Markers Following Co-Exposure of Epithelial Cells to Carbon Black (Nano)Particles in the Presence of S. aureus: A Role for Stressed Cells in Toxicological Testing. Biomedicines, 12(1), 128
https://doi.org/10.3390/biomedicines12010128, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65427
Francis, N., Ruckley, D., & Wilkinson, T. (2022). The virtual flow cytometer: A new learning experience and environment for undergraduate teaching. Frontiers in Education, 7
https://doi.org/10.3389/feduc.2022.903732, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61766

Holl Ymchwil

Erthyglau Cylchgronau

Hilliard, G., Wilkinson, T., Harris, L., Jenkins, R., & Shornick, L. (2024). PCL-gelatin honey scaffolds promote Staphylococcus aureus agrA expression in biofilms with Pseudomonas aeruginosa. Frontiers in Microbiology, 15
https://doi.org/10.3389/fmicb.2024.1440658, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67500
Azizova, L., Dalaty, A., Brousseau, E., Birchall, J., Wilkinson, T., Sloan, A., & Ayre, W. (2024). Antimicrobial release from a lipid bilayer titanium implant coating is triggered by Staphylococcus aureus alpha-haemolysin. Applied Surface Science, 665, 160337
https://doi.org/10.1016/j.apsusc.2024.160337, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66603
Chick, H., Rees, M., Lewis, M., Williams, L., Bodger, O., Harris, L., Rushton, S., & Wilkinson, T. (2024). Using the Traditional Ex Vivo Whole Blood Model to Discriminate Bacteria by Their Inducible Host Responses. Biomedicines, 12(4), 724
https://doi.org/10.3390/biomedicines12040724, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65918
Brown, S., Evans, S., Burgum, M., Meldrum, K., Herridge, J., Akinbola, B., Harris, L., Jenkins, R., Doak, S., Clift, M., & Wilkinson, T. (2024). An In Vitro Model to Assess Early Immune Markers Following Co-Exposure of Epithelial Cells to Carbon Black (Nano)Particles in the Presence of S. aureus: A Role for Stressed Cells in Toxicological Testing. Biomedicines, 12(1), 128
https://doi.org/10.3390/biomedicines12010128, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65427
Azizova, L., Morgan, D., Rowlands, J., Brousseau, E., Kulik, T., Palianytsia, B., Mansell, J., Birchall, J., Wilkinson, T., Sloan, A., & Ayre, W. (2022). Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications. Applied Surface Science, 604, 154462
https://doi.org/10.1016/j.apsusc.2022.154462, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61765
Francis, N., Ruckley, D., & Wilkinson, T. (2022). The virtual flow cytometer: A new learning experience and environment for undergraduate teaching. Frontiers in Education, 7
https://doi.org/10.3389/feduc.2022.903732, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61766
Mageiros, L., Méric, G., Bayliss, S., Pensar, J., Pascoe, B., Mourkas, E., Calland, J., Yahara, K., Murray, S., Wilkinson, T., Williams, L., Hitchings, M., Porter, J., Kemmett, K., Feil, E., Jolley, K., Williams, N., Corander, J., Sheppard, S., & Hitchings, M. (2021). Genome evolution and the emergence of pathogenicity in avian Escherichia coli. Nature Communications, 12(1)
https://doi.org/10.1038/s41467-021-20988-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56200
http://dx.doi.org/10.1038/s41467-021-20988-w
Wilkinson, T., Nibbs, R., & Francis, N. (2021). Reimagining laboratory‐based immunology education in the time of COVID‐19. Immunology, 163(4), 431-435.
https://doi.org/10.1111/imm.13369, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57219
Evans, S., Roberts, A., Morris, A., Simpson, A., Harris, L., Mack, D., Jenkins, R., & Wilkinson, T. (2020). Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury. Scientific Reports, 10(1)
https://doi.org/10.1038/s41598-020-72454-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55318
Brown, H., Metters, G., Hitchings, M., Wilkinson, T., Sousa, L., Cooper, J., Dance, H., Atterbury, R., & Jenkins, R. (2020). Antibacterial and anti-virulence activity of manuka honey against genetically diverse Staphylococcus pseudintermedius strains. Applied and Environmental Microbiology, 86(e01768-20)
https://doi.org/10.1128/aem.01768-20, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54999
Harris, L., Bodger, O., Post, V., Mack, D., Morgenstern, M., Rohde, H., Moriarty, T., & Wilkinson, T. (2020). Temporal Changes in Patient-Matched Staphylococcus epidermidis Isolates from Infections: towards Defining a ‘True’ Persistent Infection. Microorganisms, 8(10), 1508
https://doi.org/10.3390/microorganisms8101508, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55319
Harris, L., Jones, R., Velasco, M., Harris, L., Morgan, S., Temple, M., Ruddy, M., Williams, R., Perry, M., Hitchings, M., Wilkinson, T., Humphrey, T., Gilbert, M., & Davies, A. (2019). Resolving a clinical tuberculosis outbreak using palaeogenomic genome reconstruction methodologies. Tuberculosis, 119, 101865
https://doi.org/10.1016/j.tube.2019.101865, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51995
Pascoe, B., Williams, L., Calland, J., Meric, G., Hitchings, M., Dyer, M., Ryder, J., Shaw, S., Lopes, B., Chintoan-Uta, C., Allan, E., Vidal, A., Fearnley, C., Everest, P., Pachebat, J., Cogan, T., Stevens, M., Humphrey, T., Wilkinson, T...., & Sheppard, S. (2019). Domestication of Campylobacter jejuni NCTC 11168. Microbial Genomics, 5(7)
https://doi.org/10.1099/mgen.0.000279, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51148
Evans, S., Clift, M., Singh, N., Wills, J., Hondow, N., Wilkinson, T., Burgum, M., Brown, A., Jenkins, G., & Doak, S. (2019). In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials. Particle and Fibre Toxicology, 16(1)
https://doi.org/10.1186/s12989-019-0291-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48861
Sandilands, V., Whyte, F., Williams, L., Wilkinson, T., Sparks, N., Humphrey, T., Wilkinson, T., & Williams, L. (2018). Reliably colonising broiler chickens with Campylobacter spp. using a litter-based method. British Poultry Science, 1-5.
https://doi.org/10.1080/00071668.2018.1523538, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa44902
Wilkinson, T., Jenkins, G., Davies, A., Row, P., Hitchings, M., & Islam, S. (2018). Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study. BMJ Open
https://doi.org/10.1136/bmjopen-2018-021987, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45409
Berthenet, E., Yahara, K., Thorell, K., Pascoe, B., Meric, G., Mikhail, J., Engstrand, L., Enroth, H., Burette, A., Megraud, F., Varon, C., Atherton, J., Smith, S., Wilkinson, T., Hitchings, M., Falush, D., & Sheppard, S. (2018). A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk. BMC Biology, 16(1)
https://doi.org/10.1186/s12915-018-0550-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43222
Evans, S., Clift, M., Singh, N., De Oliveira Mallia, J., Burgum, M., Wills, J., Wilkinson, T., Jenkins, G., Doak, S., Jenkins, G., Wilkinson, T., & Clift, M. (2017). Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity. Mutagenesis, 32(1), 233-241.
https://doi.org/10.1093/mutage/gew054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33917
https://academic.oup.com/mutage/article/32/1/233/3865764/Critical-review-of-the-current-and-future
Harris, L., Dudley, E., Rohde, H., Frommelt, L., Siemssen, N., Wilkinson, T., & Mack, D. (2017). Limitations in the use of PSMγ, agr , RNAIII, and biofilm formation as biomarkers to define invasive Staphylococcus epidermidis from chronic biomedical device-associated infections. International Journal of Medical Microbiology, 307(7), 382-387.
https://doi.org/10.1016/j.ijmm.2017.08.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35039
Harris, L., Dudley, E., Rohde, H., Frommelt, L., Siemssen, N., Wilkinson, T., & Mack, D. (2017). Limitations in the use of PSMγ, agr , RNAIII, and biofilm formation as biomarkers to define invasive Staphylococcus epidermidis from chronic biomedical device-associated infections. International Journal of Medical Microbiology, 307(7), 382-387.
https://doi.org/10.1016/j.ijmm.2017.08.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57961
Harris, L., Dudley, E., Rohde, H., Frommelt, L., Siemssen, N., Wilkinson, T., & Mack, D. (2017). Limitations in the use of PSMγ, agr , RNAIII, and biofilm formation as biomarkers to define invasive Staphylococcus epidermidis from chronic biomedical device-associated infections. International Journal of Medical Microbiology, 307(7), 382-387.
https://doi.org/10.1016/j.ijmm.2017.08.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35065
John, D., Williams, L., Kanamarlapudi, V., Humphrey, T., & Wilkinson, T. (2017). The Bacterial Species Campylobacter jejuni Induce Diverse Innate Immune Responses in Human and Avian Intestinal Epithelial Cells. Frontiers in Microbiology, 8
https://doi.org/10.3389/fmicb.2017.01840, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35842
Murray, S., Pascoe, B., Méric, G., Mageiros, L., Yahara, K., Hitchings, M., Friedmann, Y., Wilkinson, T., Gormley, F., Mack, D., Bray, J., Lamble, S., Bowden, R., Jolley, K., Maiden, M., Wendlandt, S., Schwarz, S., Corander, J., Fitzgerald, J., & Sheppard, S. (2017). Recombination-Mediated Host Adaptation by Avian Staphylococcus aureus. Genome Biology and Evolution, 9(4), 830-842.
https://doi.org/10.1093/gbe/evx037, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52398
Harris, L., Murray, S., Pascoe, B., Bray, J., Meric, G., Mageiros, L., Wilkinson, T., Jeeves, R., Rohde, H., Schwarz, S., Lencastre, H., Miragaia, M., Rolo, J., Bowden, R., Jolley, K., Maiden, M., Mack, D., & Sheppard, S. (2016). Correction: Biofilm Morphotypes and Population Structure among Staphylococcus epidermidis from Commensal and Clinical Samples. PLOS ONE, 11(4), e0154510
https://doi.org/10.1371/journal.pone.0154510, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45872
Harris, L., Murray, S., Pascoe, B., Bray, J., Meric, G., Magerios, L., Wilkinson, T., Jeeves, R., Rohde, H., Schwarz, S., Lencastre, H., Miragaia, M., Rolo, J., Bowden, R., Jolley, K., Maiden, M., Mack, D., & Sheppard, S. (2016). Biofilm Morphotypes and Population Structure among Staphylococcus epidermidis from Commensal and Clinical Samples. PLOS ONE, 11(3), e0151240
https://doi.org/10.1371/journal.pone.0151240, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26765
Al-Ali, A., Singh, N., Manshian, B., Wilkinson, T., Wills, J., Jenkins, G., Doak, S., & Wilkinson, T. (2015). Quantum dot induced cellular perturbations involving varying toxicity pathways. Toxicol. Res.
https://doi.org/10.1039/C4TX00175C, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20114
Méric, G., Miragaia, M., de Been, M., Yahara, K., Pascoe, B., Mageiros, L., Mikhail, J., Harris, L., Wilkinson, T., Rolo, J., Lamble, S., Bray, J., Jolley, K., Hanage, W., Bowden, R., Maiden, M., Mack, D., de Lencastre, H., Feil, E...., & Meric, G. (2015). Ecological Overlap and Horizontal Gene Transfer in Staphylococcus aureus and Staphylococcus epidermidis. Genome Biology and Evolution, 7(5), 1313-1328.
https://doi.org/10.1093/gbe/evv066, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa21419
AL-Ishaq, R., Armstrong, J., Gregory, M., O’Hara, M., Phiri, K., Harris, L., Rohde, H., Siemssen, N., Frommelt, L., Mack, D., & Wilkinson, T. (2015). Effects of polysaccharide intercellular adhesin (PIA) in an ex vivo model of whole blood killing and in prosthetic joint infection (PJI): A role for C5a. International Journal of Medical Microbiology
https://doi.org/10.1016/j.ijmm.2015.08.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23338
Moncayo-Nieto, O., Wilkinson, T., Brittan, M., McHugh, B., Jones, R., Conway Morris, A., Walker, W., Davidson, D., & Simpson, A. (2014). Differential response to bacteria, and TOLLIP expression, in the human respiratory tract. BMJ Open Respiratory Research, 1(1), e000046
https://doi.org/10.1136/bmjresp-2014-000046, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20150
http://www.ncbi.nlm.nih.gov/pubmed/25478190
Pascoe, B., Dams, L., Wilkinson, T., Harris, L., Bodger, O., Mack, D., & Davies, A. (2014). Dormant Cells of Staphylococcus aureus Are Resuscitated by Spent Culture Supernatant. PLoS ONE, 9(2), e85998
https://doi.org/10.1371/journal.pone.0085998, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17301
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0085998
Conway Morris, A., Anderson, N., Brittan, M., Wilkinson, T., McAuley, D., Antonelli, J., McCulloch, C., Barr, L., Dhaliwal, K., Jones, R., Haslett, C., Hay, A., Swann, D., Laurenson, I., Davidson, D., Rossi, A., Walsh, T., Simpson, A., & Wilkinson, T. (2013). Combined dysfunctions of immune cells predict nosocomial infection in critically ill patients. British Journal of Anaesthesia, 111(5), 778-787.
https://doi.org/10.1093/bja/aet205, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20151
http://www.ncbi.nlm.nih.gov/pubmed/23756248
Morris, A., Wilkinson, T., Walsh, T., Simpson, A., & Wilkinson, T. (2013). Comment on "Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans". The Journal of Immunology, 191(10), 4893-4893.
https://doi.org/10.4049/jimmunol.1390060, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34788
http://www.scopus.com/inward/record.url?eid=2-s2.0-84887427829&partnerID=MN8TOARS
Almarashi, J., Kapel, N., Wilkinson, T., & Telle, H. (2012). Raman Spectroscopy of Bacterial Species and Strains Cultivated under Reproducible Conditions. Spectroscopy: An International Journal, 27(5-6)-365.
https://doi.org/10.1155/2012/540490, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14497
Wilkinson, T., Conway Morris, A., Kefala, K., O'Kane, C., Moore, N., Booth, N., McAuley, D., Dhaliwal, K., Walsh, T., Haslett, C., Sallenave, J., Simpson, A., & Wilkinson, T. (2012). Ventilator-Associated Pneumonia Is Characterized by Excessive Release of Neutrophil Proteases in the Lung. Chest, 142(6), 1425-1432.
https://doi.org/10.1378/chest.11-3273, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34783
http://www.scopus.com/inward/record.url?eid=2-s2.0-84870607793&partnerID=MN8TOARS
Dhaliwal, K., Scholefield, E., Ferenbach, D., Gibbons, M., Duffin, R., Dorward, D., Morris, A., Humphries, D., MacKinnon, A., Wilkinson, T., Wallace, W., Van Rooijen, N., Mack, M., Rossi, A., Davidson, D., Hirani, N., Hughes, J., Haslett, C., Simpson, A., & Wilkinson, T. (2012). Monocytes Control Second-Phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury. American Journal of Respiratory and Critical Care Medicine, 186(6), 514-524.
https://doi.org/10.1164/rccm.201112-2132OC, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34785
http://www.scopus.com/inward/record.url?eid=2-s2.0-84866371544&partnerID=MN8TOARS
Wilkinson, T. (2012). Monocytes control second-phase neutrophil emigration in established LPS-induced murine injury. Am J Respir Crit Care Med, 186(6), 514-524.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13013
http://www.ncbi.nlm.nih.gov/pubmed/22822022
Spiliopoulou, A., Krevvata, M., Kolonitsiou, F., Harris, L., Wilkinson, T., Davies, A., Dimitracopoulos, G., Karamanos, N., Mack, D., & Anastassiou, E. (2012). An extracellular Staphylococcus epidermidis polysaccharide: relation to Polysaccharide Intercellular Adhesin and its implication in phagocytosis. BMC Microbiology, 12(1), 76
https://doi.org/10.1186/1471-2180-12-76, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12279
Spiliopoulou, A., Kolonitsiou, F., Krevvata, M., Leontsinidis, M., Wilkinson, T., Mack, D., Anastassiou, E., & Wilkinson, T. (2012). Bacterial adhesion, intracellular survival and cytokine induction upon stimulation of mononuclear cells with planktonic or biofilm phase Staphylococcus epidermidis. FEMS Microbiology Letters, 330(1), 56-65.
https://doi.org/10.1111/j.1574-6968.2012.02533.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34786
http://europepmc.org/abstract/med/22360699
Morris, A., Brittan, M., Wilkinson, T., McAuley, D., Antonelli, J., McCulloch, C., Barr, L., McDonald, N., Dhaliwal, K., Jones, R., Mackellar, A., Haslett, C., Hay, A., Swann, D., Anderson, N., Laurenson, I., Davidson, D., Rossi, A., Walsh, T...., & Wilkinson, T. (2011). C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients. Blood, 117(19), 5178-5188.
https://doi.org/10.1182/blood-2010-08-304667, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10271
Wilkinson, T., Roghanian, A., Simpson, A., & Wilkinson, T. (2011). WAP domain proteins as modulators of mucosal immunity. Biochem Soc Trans, 39, 1409-1415.
https://doi.org/10.1042/BST0391409, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10320
Murray, M., Govan, J., Doherty, C., Simpson, A., Wilkinson, T., Chalmers, J., Greening, A., Haslett, C., & Hill, A. (2011). A Randomized Controlled Trial of Nebulized Gentamicin in Non–Cystic Fibrosis Bronchiectasis. American Journal of Respiratory and Critical Care Medicine, 183(4), 491-499.
https://doi.org/10.1164/rccm.201005-0756OC, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10270
Barlow, P., Beaumont, P., Cosseau, C., Mackellar, A., Wilkinson, T., Hancock, R., Haslett, C., Govan, J., Simpson, A., Davidson, D., & Wilkinson, T. (2010). The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium. American Journal of Respiratory Cell and Molecular Biology, 43(6), 692-702.
https://doi.org/10.1165/rcmb.2009-0250oc, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34781
http://europepmc.org/abstract/med/20097832
Potter-Perigo, S., Johnson, P., Evanko, S., Chan, C., Braun, K., Wilkinson, T., Altman, L., Wight, T., & Wilkinson, T. (2010). Polyinosine-Polycytidylic Acid Stimulates Versican Accumulation in the Extracellular Matrix Promoting Monocyte Adhesion. American Journal of Respiratory Cell and Molecular Biology, 43(1), 109-120.
https://doi.org/10.1165/rcmb.2009-0081OC, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34778
http://www.scopus.com/inward/record.url?eid=2-s2.0-77956893098&partnerID=MN8TOARS
Fox, S., Wilkinson, T., Wheatley, P., Xiao, B., Morris, R., Sutherland, A., Simpson, A., Barlow, P., Butler, A., Megson, I., Rossi, A., & Wilkinson, T. (2010). NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy. Acta Biomaterialia, 6(4), 1515-1521.
https://doi.org/10.1016/j.actbio.2009.10.038, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34779
http://www.scopus.com/inward/record.url?eid=2-s2.0-76949108450&partnerID=MN8TOARS
Conway Morris, A., Kefala, K., Wilkinson, T., & Wilkinson, T. (2010). Correction. Thorax, 65(9), 844-844.
https://doi.org/10.1136/thx.2009.122291corr1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34780
http://www.scopus.com/inward/record.url?eid=2-s2.0-77956835698&partnerID=MN8TOARS
Fox, S., Wilkinson, T., Wheatley, P., & Wilkinson, T. (2010). NO-loaded Zn2+-Exchanged Zeolite Materials; A Potential Bi-Functional Anti-Bacterial Strategy. Acta Biomaterialia, 692-702.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10012
Conway Morris, A., Kefala, K., Wilkinson, T., Dhaliwal, K., Farrell, L., Walsh, T., Mackenzie, S, J., Reid, H., Davidson, D., Haslett, C., Rossi, A., J-M, S., Simpson, A., & Wilkinson, T. (2009). C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. American Journal of Respiratory and Critical Care Medicine, 180(1), 19-28.
https://doi.org/10.1164/rccm.200812-1928OC, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10268
Marriott, H., Jackson, L., Wilkinson, T., Simpson, A., Mitchell, T., Buttle, D., Cross, S., Ince, P., Hellewell, P., Whyte, M., & Dockrell, D. (2008). Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia. American Journal of Respiratory and Critical Care Medicine, 177(8), 887-895.
https://doi.org/10.1164/rccm.200707-990OC, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10267
Farnworth, S., Henderson, N., Mackinnon, A., Atkinson, K., Wilkinson, T., Dhaliwal, K., Hayashi, K., Simpson, A., Rossi, A., Haslett, C., Sethi, T., & Wilkinson, T. (2008). Galectin-3 Reduces the Severity of Pneumococcal Pneumonia by Augmenting Neutrophil Function. The American Journal of Pathology, 172(2), 395-405.
https://doi.org/10.2353/ajpath.2008.070870, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34776
http://europepmc.org/abstract/med/18202191
Barlow, P., Li, Y., Wilkinson, T., Bowdish, D., Lau, Y., Cosseau, C., Haslett, C., Simpson, A., Hancock, R., Davidson, D., & Wilkinson, T. (2006). The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. Journal of Leukocyte Biology, 80(3), 509-520.
https://doi.org/10.1189/jlb.1005560, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34774
http://www.scopus.com/inward/record.url?eid=2-s2.0-33751532376&partnerID=MN8TOARS
Wilkinson, T., Bressler, S., Evanko, S., Braun, K., Wight, T., & Wilkinson, T. (2006). Overexpression of hyaluronan synthases alters vascular smooth muscle cell phenotype and promotes monocyte adhesion. Journal of Cellular Physiology, 206(2), 378-385.
https://doi.org/10.1002/jcp.20468, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34775
http://www.scopus.com/inward/record.url?eid=2-s2.0-30344461304&partnerID=MN8TOARS
Wilkinson, T., Potter-Perigo, S., Tsoi, C., Altman, L., Wight, T., & Wilkinson, T. (2004). Pro- and Anti-Inflammatory Factors Cooperate to Control Hyaluronan Synthesis in Lung Fibroblasts. American Journal of Respiratory Cell and Molecular Biology, 31(1), 92-99.
https://doi.org/10.1165/rcmb.2003-0380OC, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34772
http://www.scopus.com/inward/record.url?eid=2-s2.0-3042838546&partnerID=MN8TOARS
McLoughlin, R., Hurst, S., Nowell, M., Harris, D., Horiuchi, S., Morgan, L., Wilkinson, T., Yamamoto, N., Topley, N., Jones, S., & Wilkinson, T. (2004). Differential Regulation of Neutrophil-Activating Chemokines by IL-6 and Its Soluble Receptor Isoforms. The Journal of Immunology, 172(9), 5676-5683.
https://doi.org/10.4049/jimmunol.172.9.5676, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34773
http://europepmc.org/abstract/med/15100312
McLoughlin, R., Witowski, J., Robson, R., Wilkinson, T., Hurst, S., Williams, A., Williams, J., Rose-John, S., Jones, S., Topley, N., & Wilkinson, T. (2003). Interplay between IFN-γ and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. Journal of Clinical Investigation, 112(4), 598-607.
https://doi.org/10.1172/jci17129, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34771
http://europepmc.org/abstract/med/12925700
Hurst, S., Wilkinson, T., McLoughlin, R., Jones, S., Horiuchi, S., Yamamoto, N., Rose-John, S., Fuller, G., Topley, N., Jones, S., & Wilkinson, T. (2001). IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation. Immunity, 14(6), 705-714.
https://doi.org/10.1016/S1074-7613(01)00151-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34768
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034960582&partnerID=MN8TOARS
Robson, R., McLoughlin, R., Witowski, J., Loetscher, P., Wilkinson, T., Jones, S., Topley, N., & Wilkinson, T. (2001). Differential Regulation of Chemokine Production in Human Peritoneal Mesothelial Cells: IFN- Controls Neutrophil Migration Across the Mesothelium In Vitro and In Vivo. The Journal of Immunology, 167(2), 1028-1038.
https://doi.org/10.4049/jimmunol.167.2.1028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34769
http://europepmc.org/abstract/med/11441112
Davenport, A., Li, F., Robson, R., Wilkinson, T., McLoughlin, R., Topley, N., & Wilkinson, T. (1999). Early peritoneal responses to bacterial invasion: Cellular exudation. Sepsis, 3(4), 303-309.
https://doi.org/10.1023/A:1009801427397, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34767
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033306668&partnerID=MN8TOARS

Llyfrau Awdurol

Mack, D., Davies, A., Harris, L., Jeeves, R., Pascoe, B., Knobloch, J., Rohde, H., Wilkinson, T., & Wilkinson, T. (2013). Biomaterials Associated Infection
https://doi.org/10.1007/978-1-4614-1031-7_2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34787
http://www.scopus.com/inward/record.url?eid=2-s2.0-84901799453&partnerID=MN8TOARS

Goruchwyliaeth

Blood Raman spectroscopy and breast cancer: towards early diagnosis and personalised medicine (cyfredol)

MD

Goruchwyliwr arall: Prof Peter Dunstan
Developing models of host/pathogen co-transcription to study underlying mechanisms and discover biomarkers in invasive bacterial diseases. (cyfredol)

PhD

Goruchwyliwr arall: Dr Lydia Powell
Methods to study E.coli extra-intestinal spread: towards the understanding and early diagnosis of sepsis. (cyfredol)

PhD

Goruchwyliwr arall: Dr Llinos Harris
Understanding the mechanobiological interaction between immune responses and bacterial biofilms to overcome antibiotic resistance by therapeutic design. (cyfredol)

PhD

Goruchwyliwr arall: Dr Lydia Powell
Rheological characterisation of blood components and the effects of lipopolysaccharide induced inflammation (cyfredol)

PhD

Goruchwyliwr arall: Prof Karl Hawkins
Identifying Host and Bacterial Biomarkers to Predict Sepsis (dyfarnwyd 2024)

PhD

Goruchwyliwr arall: Dr Rowena Jenkins

Goruchwyliwr arall: Dr Llinos Harris
Controlling the Public and Animal Health Threat from Campylobacter Infection in Broiler Chickens by Improving Gut Health and Reducing Inflammation. (dyfarnwyd 2024)

PhD

Goruchwyliwr arall: Prof Martin Sheldon
Understanding the Seasonality of Campylobacter Infection among Commercial Broiler Chickens in the United Kingdom (dyfarnwyd 2024)

PhD

Goruchwyliwr arall: Prof Martin Sheldon
Molecular and Cellular Analysis of Endothelial Permeability in Sepsis (dyfarnwyd 2024)

PhD

Goruchwyliwr arall: Prof Venkat Kanamarlapudi
Characterising the impact of targeted neutrophil oxidative burst on Escherichia coli (cyfredol)

MSc

Goruchwyliwr arall: Dr Heather Chick
Conditions for biofilm formation in extrapathogenic E. coli (ExPEC) (cyfredol)

MSc

Goruchwyliwr arall: Dr Llinos Harris
Staphylococcus epidermidis, Host Immune Factors and Medical Device Infections. (dyfarnwyd 2023)

MSc

Goruchwyliwr arall: Dr Llinos Harris

Modiwlau a Addysgir

PM-004 Fundamentals of Microbiology & Disease

This module will provide the student with an overview of the fundamentals of microbiology, its causative role in human disease and the intervention of antimicrobials and antibiotics. The role of immunity and its role in human defence against disease will also be introduced in this module, and how this may be modulated in response to pathogens. Lectures will be accompanied by a practical session in microbiological techniques and an essay with academic support. Mae'r modiwl yma yn rhoi trosolwg i fyfyrwyr o hanfodion mewn microbioleg, ei rôl achosol mewn afiechydon dynol ac ymyrraeth gwrthficrobaidd a gwrthfiotig. Caiff rôl imiwnedd a'i rôl mewn amddiffyn dyn yn erbyn afiechydon, a sut mae'n addasu mewn ymateb i bathogenau ei gyflwyno hefyd yn y modiwl yma. Caiff y darlithoedd eu cyfeilio gan sesiynau ymarferol mewn technegau microbiolegol a traethawd efo cefnogaeth academaidd.
PM-130 Fundamental Research Skills

This module is designed to develop the skills required for students of biochemistry and genetics degree programmes. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
PM-132 Eukaryotic Cell Biology

This module will provide students with a broad introduction to fundamental concepts in Eukaryotic cell biology, such as investigating the origins of the cell, the structure or eukaryotic cells, the different types of specialised cells, and cells which help prevent disease. There will be a general focus on human cells throughout the module with some references to other organisms when needed. Students will gain practical experience in identification and differentiation of cells from different human and animal species.
PM-132C Bioleg Celloedd Ewcaryotig

Bydd y modiwl hwn yn darparu cyflwyniad bras i gysyniadau sylfaenol ym maes bioleg celloedd Ewcaryotig, gan ymchwilio i darddiad y gell, strwythur y gell a chelloedd arbenigol a chelloedd mewn clefyd. Bydd ffocws cyffredinol ar gelloedd dynol drwy gydol y modiwl, gan gyfeirio at organebau eraill yn ôl yr angen. Bydd myfyrwyr yn cael profiad ymarferol o nodi celloedd, gwahaniaethu rhwng gwahanol gelloedd dynol a rhywogaethau o anifeiliaid.
PM-249 Human Immunology

The course is designed as an introduction to immunology and the human immune system. The course covers the fundamentals of immunology including functional perturbations associated with disease and experimental approaches to the study of immunology.
PM-249C Imiwnoleg Ddynol

Mae'r cwrs wedi'i gynllunio i fod yn gyflwyniad i imiwnoleg a'r system imiwnedd ddynol. Mae'r cwrs yn cyflwyno hanfodion imiwnoleg, gan gynnwys aflonyddiadau gweithrediadol sy'n gysylltiedig â chlefyd ac ymagweddau arbrofol at astudio imiwnoleg.
PM-250 Infectious Diseases

The course will build on the fundamentals of microbiology and introduce new topics in bacteriology, mycology, virology and parasitology. Level 5 Immunology (PM-249) is a co-requisite. The course covers the fundamentals of infectious diseases, including clinical aspects, treatment / prevention, and experimental approaches to the study of infectious and parasitic organisms.
PM-250C Clefydau heintus

Bydd y cwrs yn adeiladu ar sylfeini microbioleg ac yn cyflwyno pynciau newydd ym meysydd bacterioleg, mycoleg, firoleg a pharasitoleg. Mae Imiwnoleg Lefel 5 (PM-249) yn rhagofyniad. Mae'r cwrs yn ymdrin ag egwyddorion sylfaenol clefydau heintus, gan gynnwys agweddau clinigol, triniaeth/atal, ac ymagweddau arbrofol at astudio organebau heintus a pharasitig.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-344C Prosiect Capfaen

Nod y modiwl hwn yw rhoi cyfle i fyfyrwyr gael profiad dysgu capfaen drwy gymryd rhan yn eu prosiect eu hunain yn seiliedig ar gwestiwn ymchwil. Gall y prosiect fod mewn labordy neu heb fod yn labordy ond bydd bob amser yn cynnwys cwestiwn ymchwil sy'n deillio o'r llenyddiaeth, ac sy'n canolbwyntio ar bwnc perthnasol i wyddor feddygol. Bydd yn gofyn cwestiwn ymchwil newydd ac yn cynnwys dadansoddiad beirniadol o ganfyddiadau ymchwil. Bydd myfyrwyr yn mireinio eu sgiliau cyfathrebu llafar ac ysgrifenedig i lefel raddedig, drwy lunio cyflwyniad rhagarweiniol ar gefndir y prosiect, ynghyd â thraethawd estynedig a chyflwyniad llafar ar ganfyddiadau eu hymchwil.
PM-347 Human Immunopathology

The module aims to provide students with a greater understanding of the human immune system and the causes of a range of diseases associated with immune dysfunction including autoimmune diseases, metabolic disorders and neurological conditions.
PMRM04 Dissertation (Research)

This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study.

Grantiau a Phrosiectau Allweddol

The effect of electrospun nanofibre diameter and conditioning film on controlling active biofilm formation in wound dressings 2020

Ariennir gan y Ganolfan Arloesi Bioffilmiau, £49,000
Identifying host and bacterial biomarkers to predict sepsis 2019

Ariennir gan Ymchwil Iechyd a Gofal Cymru, £66,000
Host pathogen interactions important in the movement of Campylobacter from the broiler chicken gut to edible tissues (CampAttack) 2018

Ariennir gan Gyngor Ymchwil Biotechnoleg a’r Biowyoddorau, £864,000
Expression and activity determination of novel cloned antibiofilm peptides 2015

Rhwydwaith Ymchwil y Gwyddorau Bywyd Cymru, £49,993

Hanes Gyrfa

Darlithydd mewn Microbioleg a Chlefydau Heintus, Ysgol Feddygaeth Prifysgol Abertawe

2008 - 2010
Uwch-ddarlithydd mewn Microbioleg a Chlefydau Heintus, Ysgol Feddygaeth Prifysgol Abertawe

2010 - 2015
Athro Cysylltiol mewn Microbioleg a Chlefydau Heintu, Ysgol Feddygaeth Prifysgol Abertawe

2015 - Presennol

Rolau Eraill

Dirprwy Gyfarwyddwr Ymchwil Ôl-raddedig, Ysgol Feddygaeth Prifysgol Abertawe

2010 - 2013
Cyfarwyddwr Ymchwil Ôl-raddedig, Ysgol Feddygaeth Prifysgol Abertawe

2013 - 2016
Dirprwy Gyfarwyddwr Ymchwil Ôl-raddedig, Ysgol Feddygaeth Prifysgol Abertawe

2016 - Presennol
Aelod panel REF 2021, Ysgol Feddygaeth Prifysgol Abertawe

2014 - Presennol

Ymgysylltu Cyhoeddus

Mae Dr Wilkinson wedi achub ar gyfleoedd i ymgysylltu â'r cyhoedd yn ddiweddar ac mae wedi cyflwyno mewn digwyddiadau niferus yn y blynyddoedd diweddar. Mae'r rhain yn cynnwys 'Pint of Science', Gŵyl Wyddoniaeth Prydain, grwpiau Brownies lleol a grwpiau'r Sefydliad Gyrwyr Uwch. Mae Dr Wilkinson yn siarad Cymraeg ac mae wedi cymryd rhan mewn cyfweliadau ar Newyddion Saith a Radio Cymru am ddatblygiadau diweddar ym maes ymchwil i heintio a bu hefyd yn un o'r tiwtoriaid ar gwrs Gwyddoniaeth ar-lein newydd a gynhyrchwyd gan Telesgop.

Yr Athro Thomas Wilkinson

Cyfeiriad ebost

Welsh language proficiency

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Uchafbwyntiau Ymchwil

Holl Ymchwil

Blood Raman spectroscopy and breast cancer: towards early diagnosis and personalised medicine (cyfredol)

Developing models of host/pathogen co-transcription to study underlying mechanisms and discover biomarkers in invasive bacterial diseases. (cyfredol)

Methods to study E.coli extra-intestinal spread: towards the understanding and early diagnosis of sepsis. (cyfredol)

Understanding the mechanobiological interaction between immune responses and bacterial biofilms to overcome antibiotic resistance by therapeutic design. (cyfredol)

Rheological characterisation of blood components and the effects of lipopolysaccharide induced inflammation (cyfredol)

Identifying Host and Bacterial Biomarkers to Predict Sepsis (dyfarnwyd 2024)

Controlling the Public and Animal Health Threat from Campylobacter Infection in Broiler Chickens by Improving Gut Health and Reducing Inflammation. (dyfarnwyd 2024)

Understanding the Seasonality of Campylobacter Infection among Commercial Broiler Chickens in the United Kingdom (dyfarnwyd 2024)

Molecular and Cellular Analysis of Endothelial Permeability in Sepsis (dyfarnwyd 2024)

Characterising the impact of targeted neutrophil oxidative burst on Escherichia coli (cyfredol)

Conditions for biofilm formation in extrapathogenic E. coli (ExPEC) (cyfredol)

Staphylococcus epidermidis, Host Immune Factors and Medical Device Infections. (dyfarnwyd 2023)

PM-004 Fundamentals of Microbiology & Disease

PM-130 Fundamental Research Skills

PM-132 Eukaryotic Cell Biology

PM-132C Bioleg Celloedd Ewcaryotig

PM-249 Human Immunology

PM-249C Imiwnoleg Ddynol

PM-250 Infectious Diseases

PM-250C Clefydau heintus

PM-344 Capstone Project

PM-344C Prosiect Capfaen

PM-347 Human Immunopathology

PMRM04 Dissertation (Research)

The effect of electrospun nanofibre diameter and conditioning film on controlling active biofilm formation in wound dressings 2020

Identifying host and bacterial biomarkers to predict sepsis 2019

Host pathogen interactions important in the movement of Campylobacter from the broiler chicken gut to edible tissues (CampAttack) 2018

Expression and activity determination of novel cloned antibiofilm peptides 2015

Darlithydd mewn Microbioleg a Chlefydau Heintus, Ysgol Feddygaeth Prifysgol Abertawe

Uwch-ddarlithydd mewn Microbioleg a Chlefydau Heintus, Ysgol Feddygaeth Prifysgol Abertawe

Athro Cysylltiol mewn Microbioleg a Chlefydau Heintu, Ysgol Feddygaeth Prifysgol Abertawe

Dirprwy Gyfarwyddwr Ymchwil Ôl-raddedig, Ysgol Feddygaeth Prifysgol Abertawe

Cyfarwyddwr Ymchwil Ôl-raddedig, Ysgol Feddygaeth Prifysgol Abertawe

Dirprwy Gyfarwyddwr Ymchwil Ôl-raddedig, Ysgol Feddygaeth Prifysgol Abertawe

Aelod panel REF 2021, Ysgol Feddygaeth Prifysgol Abertawe