Dr Gill Conway

Uwch Swyddog Ymchwil - CutCancer

Biomedical Sciences

+44 (0) 1792 295230

gillian.conway@abertawe.ac.uk

403
Pedwerydd Llawr - DNA/Genetics
Y Sefydliad Gwyddor Bywyd 1
Campws Singleton

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0002-5991-0960

Google Scholar

Trosolwg

Mae Dr. Conway yn swyddog Ymchwil a rheolwr labordy yn y grŵp Tocsicoleg In Vitro yn Ysgol Feddygaeth Prifysgol Abertawe. Cwblhaodd ei BSc mewn Gwyddoniaeth Fio-foleciwlaidd a PhD ym maes bioleg foleciwlaidd a therapiwteg canser ym Mhrifysgol Dechnolegol Dulyn, Iwerddon. Mae hi hefyd wedi gweithio o'r blaen yn y Sefydliad Cenedlaethol ar gyfer ymchwil a hyfforddi Biobrosesu (NIBRT) yn Iwerddon cyn dod i Brifysgol Abertawe.

Meysydd Arbenigedd

Bioleg canser
Modelau celloedd in vitro
Nutraceuticals
Signalau celloedd
Tocsicoleg Genetig
Niwed i DNA

Uchafbwyntiau Gyrfa

Ymchwil

Mae Dr. Conway yn rhan o'r Grŵp Tocsicoleg In Vitro dan arweiniad yr Athro Shareen Doak. Mae ei hymchwil o fewn y grŵp yn canolbwyntio ar ddatblygu modelau rhagfynegol in vitro a bioassays i gefnogi asesiad peryglon nanomaterial peirianyddol. Nod y datblygiadau hyn yw lleihau'r ddibyniaeth ar arbrofi ar anifeiliaid.

Mae gan Gillian ddiddordeb arbennig hefyd mewn ymchwilio i ddulliau therapiwtig newydd ar gyfer trin canser. Mae gwelliannau wrth ganfod a thrin canser wedi arwain at gyfraddau goroesi cyfartalog uwch sydd bellach chwe gwaith yn hirach na'r rhai a adroddwyd ddeugain mlynedd yn ôl. Fodd bynnag, mae nifer o ganserau'n parhau i wrthsefyll y rhan fwyaf o driniaethau, gan arwain at gyfradd uchel o ailymddangosiad tiwmor. Mae ymchwil Gillian yn canolbwyntio ar ymchwilio i gyfansoddion bioactif sy'n deillio yn naturiol fel dulliau therapiwtig newydd ar gyfer trin canser yr ymennydd.

Prif Wobrau Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473
https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
He, Z., Charleton, C., Devine, R., Kelada, M., Walsh, J., Conway, G., Gunes, S., Mondala, J., Tian, F., Tiwari, B., Kinsella, G., Malone, R., O'Shea, D., Devereux, M., Wang, W., Cullen, P., Stephens, J., & Curtin, J. (2021). Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma. European Journal of Medicinal Chemistry, 224, 113736
https://doi.org/10.1016/j.ejmech.2021.113736, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65435
Metcalfe, R., Kemp, R., Heffernan, S., Churm, R., Chen, Y., Ruffino, J., Conway, G., Tornillo, G., & Orange, S. (2021). Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities. European Journal of Applied Physiology, 121
https://doi.org/10.1007/s00421-021-04680-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56708
Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
Llewellyn, S., Niemeijer, M., Nymark, P., Moné, M., Water, B., Conway, G., Jenkins, G., & Doak, S. (2021). In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, 17(15), 2006055
https://doi.org/10.1002/smll.202006055, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56073
Heffernan, S. & Conway, G. (2021). Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis. Pain Management - Practices, Novel Therapies and Bioactives IntechOpen
https://doi.org/10.5772/intechopen.95919, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65436
Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.
https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
Llewellyn, S., Conway, G., Shah, U., Evans, S., Jenkins, G., Clift, M., & Doak, S. (2020). Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. Journal of Visualized Experiments(160)
https://doi.org/10.3791/61141, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54416
Conway, G., Heffernan, S., Horner, K., De Vito, G., & Conway, G. (2019). The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review. Nutrients, 11(3), 696
https://doi.org/10.3390/nu11030696, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51435
Conway, G., He, Z., Hutanu, A., Cribaro, G., Manaloto, E., Casey, A., Traynor, D., Milosavljevic, V., Howe, O., Barcia, C., Murray, J., Cullen, P., & Curtin, J. (2019). Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells. Scientific Reports, 9(1)
https://doi.org/10.1038/s41598-019-49013-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55404
He, Z., Liu, K., Manaloto, E., Casey, A., Cribaro, G., Byrne, H., Tian, F., Barcia, C., Conway, G., Cullen, P., & Curtin, J. (2018). Cold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death. Scientific Reports, 8(1)
https://doi.org/10.1038/s41598-018-23262-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51508
Conway, G., Casey, A., Milosavljevic, V., Liu, Y., Howe, O., Cullen, P., & Curtin, J. (2016). Non-thermal atmospheric plasma induces ROS-independent cell death in U373MG glioma cells and augments the cytotoxicity of temozolomide. British Journal of Cancer, 114(4), 435-443.
https://doi.org/10.1038/bjc.2016.12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55405
Conway, G., Zizyte, D., Mondala, J., He, Z., Lynam, L., Lecourt, M., Barcia, C., Howe, O., & Curtin, J. (2021). Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells. Pharmaceuticals, 14(2), 91
https://doi.org/10.3390/ph14020091, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65440
Ummat, V., Sivagnanam, S., Rai, D., O’Donnell, C., Conway, G., Heffernan, S., Fitzpatrick, S., Lyons, H., Curtin, J., & Tiwari, B. (2024). Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization. Scientific Reports, 14(1)
https://doi.org/10.1038/s41598-024-55225-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65672
Suh, M., Park, J., Ko, G., Kim, J., Hwang, D., Rees, L., Conway, G., Doak, S., Kang, H., Lee, N., Hyeon, T., Lee, Y., & Lee, D. (2024). Optimization of micelle-encapsulated extremely small sized iron oxide nanoparticles as a T1 contrast imaging agent: biodistribution and safety profile. Journal of Nanobiotechnology, 22(1)
https://doi.org/10.1186/s12951-024-02699-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67147
John, K., Page, J., Heffernan, S., Conway, G., Bezodis, N., Kilduff, L., Clark, B., Périard, J., & Waldron, M. (2024). The effect of a 4-week, remotely administered, post-exercise passive leg heating intervention on determinants of endurance performance. European Journal of Applied Physiology, 0
https://doi.org/10.1007/s00421-024-05558-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67172
Heffernan, S., Conway, G., McCarthy, C., Eustace, S., Waldron, M., Vito, G., & Delahunt, E. (2024). Inflammatory markers in early knee joint osteoarthritis differ from well-matched controls and are associated with consistent, rather than intermittent knee pain. The Knee, 51, 189-198.
https://doi.org/10.1016/j.knee.2024.09.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67729

Holl Ymchwil

Erthyglau Cylchgronau

Heffernan, S., Conway, G., McCarthy, C., Eustace, S., Waldron, M., Vito, G., & Delahunt, E. (2024). Inflammatory markers in early knee joint osteoarthritis differ from well-matched controls and are associated with consistent, rather than intermittent knee pain. The Knee, 51, 189-198.
https://doi.org/10.1016/j.knee.2024.09.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67729
John, K., Page, J., Heffernan, S., Conway, G., Bezodis, N., Kilduff, L., Clark, B., Périard, J., & Waldron, M. (2024). The effect of a 4-week, remotely administered, post-exercise passive leg heating intervention on determinants of endurance performance. European Journal of Applied Physiology, 0
https://doi.org/10.1007/s00421-024-05558-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67172
Suh, M., Park, J., Ko, G., Kim, J., Hwang, D., Rees, L., Conway, G., Doak, S., Kang, H., Lee, N., Hyeon, T., Lee, Y., & Lee, D. (2024). Optimization of micelle-encapsulated extremely small sized iron oxide nanoparticles as a T1 contrast imaging agent: biodistribution and safety profile. Journal of Nanobiotechnology, 22(1)
https://doi.org/10.1186/s12951-024-02699-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67147
Ummat, V., Sivagnanam, S., Rai, D., O’Donnell, C., Conway, G., Heffernan, S., Fitzpatrick, S., Lyons, H., Curtin, J., & Tiwari, B. (2024). Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization. Scientific Reports, 14(1)
https://doi.org/10.1038/s41598-024-55225-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65672
Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473
https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
He, Z., Charleton, C., Devine, R., Kelada, M., Walsh, J., Conway, G., Gunes, S., Mondala, J., Tian, F., Tiwari, B., Kinsella, G., Malone, R., O'Shea, D., Devereux, M., Wang, W., Cullen, P., Stephens, J., & Curtin, J. (2021). Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma. European Journal of Medicinal Chemistry, 224, 113736
https://doi.org/10.1016/j.ejmech.2021.113736, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65435
Metcalfe, R., Kemp, R., Heffernan, S., Churm, R., Chen, Y., Ruffino, J., Conway, G., Tornillo, G., & Orange, S. (2021). Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities. European Journal of Applied Physiology, 121
https://doi.org/10.1007/s00421-021-04680-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56708
Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
Llewellyn, S., Niemeijer, M., Nymark, P., Moné, M., Water, B., Conway, G., Jenkins, G., & Doak, S. (2021). In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, 17(15), 2006055
https://doi.org/10.1002/smll.202006055, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56073
Conway, G., Zizyte, D., Mondala, J., He, Z., Lynam, L., Lecourt, M., Barcia, C., Howe, O., & Curtin, J. (2021). Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells. Pharmaceuticals, 14(2), 91
https://doi.org/10.3390/ph14020091, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65440
Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.
https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
Llewellyn, S., Conway, G., Shah, U., Evans, S., Jenkins, G., Clift, M., & Doak, S. (2020). Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. Journal of Visualized Experiments(160)
https://doi.org/10.3791/61141, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54416
Conway, G., Heffernan, S., Horner, K., De Vito, G., & Conway, G. (2019). The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review. Nutrients, 11(3), 696
https://doi.org/10.3390/nu11030696, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51435
Conway, G., He, Z., Hutanu, A., Cribaro, G., Manaloto, E., Casey, A., Traynor, D., Milosavljevic, V., Howe, O., Barcia, C., Murray, J., Cullen, P., & Curtin, J. (2019). Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells. Scientific Reports, 9(1)
https://doi.org/10.1038/s41598-019-49013-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55404
He, Z., Liu, K., Manaloto, E., Casey, A., Cribaro, G., Byrne, H., Tian, F., Barcia, C., Conway, G., Cullen, P., & Curtin, J. (2018). Cold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death. Scientific Reports, 8(1)
https://doi.org/10.1038/s41598-018-23262-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51508
Conway, G., Casey, A., Milosavljevic, V., Liu, Y., Howe, O., Cullen, P., & Curtin, J. (2016). Non-thermal atmospheric plasma induces ROS-independent cell death in U373MG glioma cells and augments the cytotoxicity of temozolomide. British Journal of Cancer, 114(4), 435-443.
https://doi.org/10.1038/bjc.2016.12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55405

Penodau Llyfrau

Heffernan, S. & Conway, G. (2021). Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis. Pain Management - Practices, Novel Therapies and Bioactives IntechOpen
https://doi.org/10.5772/intechopen.95919, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65436

Modiwlau a Addysgir

PM-M28 Nano(geno)toxicology

The field of nanotechnology is ever increasing in size, and the number of nano-sized (1-100nm) particles being produced on a daily basis is at the tonnage level. Although nanotechnology-based applications are considered to be advantageous for a plethora of human activities, the potential risks posed by human exposure to nanoparticles is a constantly developing field of research. The purpose of this module therefore is to introduce to the student to particle toxicology and how it can impact upon human health. Further to this, the students will undertake a specific practical component to complement that of the theoretical content of the module. To this extent, the students will undertake a week-long, 'mini-project', covering the major areas of nanoparticle toxicology. From this approach, it is intended that the student will experience the key practical approaches taken in the field.
PMLM22 Laboratory Measurement Techniques for Medical Sciences

This module will enable students to understand the basic and advanced concepts of laboratory and measurement techniques used in medical sciences, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.

Dr Gill Conway

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