Dr Michael Burgum

Swyddog Ymchwil

Biomedical Sciences

+44 (0) 1792 205678 ext 1597

m.j.burgum@abertawe.ac.uk

Siaradwr Cymraeg Sylfaenol

403
Pedwerydd Llawr - DNA/Genetics
Y Sefydliad Gwyddor Bywyd 1
Campws Singleton

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Trosolwg

Enillodd Mike ei PhD mewn Tocsicoleg Enetig o Brifysgol Abertawe yn 2019; roedd ei draethawd ymchwil yn canolbwyntio ar y perygl sy’n gysylltiedig â mewnanadlu nanoddeunyddiau mewn modelau 2D ac in vitro uwch yr ysgyfaint.

Ers ennill ei PhD, mae Mike bellach yn uwch-aelod ôl-ddoethurol o Grŵp Tocsicoleg In Vitro Prifysgol Abertawe. Ar hyn o bryd, mae Mike yn rhan o brosiectau Horizon 2020 RiskGONE a NanoInformaTIX fel Swyddog Ymchwil, sy'n cynnwys amrywiaeth o bartneriaid a chydweithredwyr Ewropeaidd. Mae ei brif rôl yn canolbwyntio ar ganfod risgiau i iechyd dynol a rheoli nanoddeunyddau wedi'u dyfeisio mewn genotocsicoleg gyda'r nod o ddatblygu protocolau genotocsicoleg yn benodol ar gyfer nanddeunyddiau.

Prif ddiddordebau ymchwil Mike yw tocsicoleg reoleiddiol, mwtagenedd nanoddeunyddiau a nodweddu nanoddeunyddiau.

Meysydd Arbenigedd

Nodweddu nanoddeunyddiau
Mwtagenedd nanoddeunyddiau
Profion Tocsicoleg Enetig
Microsgopeg Electron

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Evans, S., Clift, M., Singh, N., Wills, J., Hondow, N., Wilkinson, T., Burgum, M., Brown, A., Jenkins, G., & Doak, S. (2019). In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials. Particle and Fibre Toxicology, 16(1)
https://doi.org/10.1186/s12989-019-0291-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48861
Burgum, M., Clift, M., Evans, S., Hondow, N., Miller, M., Bustamante-Lopez, S., Williams, A., Tarat, A., Jenkins, G., & Doak, S. (2021). In Vitro Primary‐Indirect Genotoxicity in Bronchial Epithelial Cells Promoted by Industrially Relevant Few‐Layer Graphene. Small, 17(15), 2002551
https://doi.org/10.1002/smll.202002551, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54412
Burgum, M., Clift, M., Evans, S., Hondow, N., Tarat, A., Jenkins, G., & Doak, S. (2021). Few-layer graphene induces both primary and secondary genotoxicity in epithelial barrier models in vitro. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00769-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56078
Llewellyn, S., Parak, W., Hühn, J., Burgum, M., Evans, S., Chapman, K., Jenkins, G., Doak, S., & Clift, M. (2022). Deducing the cellular mechanisms associated with the potential genotoxic impact of gold and silver engineered nanoparticles upon different lung epithelial cell lines in vitro. Nanotoxicology, 16(1), 52-72.
https://doi.org/10.1080/17435390.2022.2030823, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59210
Evans, S., Lawrence, R., Ilett, M., Burgum, M., Meldrum, K., Hondow, N., Jenkins, G., Clift, M., & Doak, S. (2022). Industrial-relevant TiO2 types do not promote cytotoxicity in the A549 or TK6 cell lines regardless of cell specific interaction. Toxicology in Vitro, 83, 105415
https://doi.org/10.1016/j.tiv.2022.105415, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60312
Brown, S., Evans, S., Burgum, M., Meldrum, K., Herridge, J., Akinbola, B., Harris, L., Jenkins, R., Doak, S., Clift, M., & Wilkinson, T. (2024). An In Vitro Model to Assess Early Immune Markers Following Co-Exposure of Epithelial Cells to Carbon Black (Nano)Particles in the Presence of S. aureus: A Role for Stressed Cells in Toxicological Testing. Biomedicines, 12(1), 128
https://doi.org/10.3390/biomedicines12010128, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65427
Burgum, M., Ulrich, C., Partosa, N., Evans, S., Gomes, C., Seiffert, S., Landsiedel, R., Honarvar, N., & Doak, S. (2024). Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices. Mutagenesis, 39(3), 205-217.
https://doi.org/10.1093/mutage/geae010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65963
http://dx.doi.org/10.1093/mutage/geae010
Jeliazkova, N., Longhin, E., Yamani, N., Rundén-Pran, E., Moschini, E., Serchi, T., Vrček, I., Burgum, M., Doak, S., Cimpan, M., Rios-Mondragon, I., Cimpan, E., Battistelli, C., Bossa, C., Tsekovska, R., Drobne, D., Novak, S., Repar, N., Ammar, A...., & Dusinska, M. (2024). A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials. Nature Protocols, 19(9), 2642-2684.
https://doi.org/10.1038/s41596-024-00993-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66932
Meldrum, K., Evans, S., Burgum, M., Doak, S., & Clift, M. (2024). Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro. Particle and Fibre Toxicology, 21(1)
https://doi.org/10.1186/s12989-024-00584-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66993

Holl Ymchwil

Erthyglau Cylchgronau

Jeliazkova, N., Longhin, E., Yamani, N., Rundén-Pran, E., Moschini, E., Serchi, T., Vrček, I., Burgum, M., Doak, S., Cimpan, M., Rios-Mondragon, I., Cimpan, E., Battistelli, C., Bossa, C., Tsekovska, R., Drobne, D., Novak, S., Repar, N., Ammar, A...., & Dusinska, M. (2024). A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials. Nature Protocols, 19(9), 2642-2684.
https://doi.org/10.1038/s41596-024-00993-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66932
Meldrum, K., Evans, S., Burgum, M., Doak, S., & Clift, M. (2024). Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro. Particle and Fibre Toxicology, 21(1)
https://doi.org/10.1186/s12989-024-00584-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66993
Burgum, M., Ulrich, C., Partosa, N., Evans, S., Gomes, C., Seiffert, S., Landsiedel, R., Honarvar, N., & Doak, S. (2024). Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices. Mutagenesis, 39(3), 205-217.
https://doi.org/10.1093/mutage/geae010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65963
http://dx.doi.org/10.1093/mutage/geae010
Brown, S., Evans, S., Burgum, M., Meldrum, K., Herridge, J., Akinbola, B., Harris, L., Jenkins, R., Doak, S., Clift, M., & Wilkinson, T. (2024). An In Vitro Model to Assess Early Immune Markers Following Co-Exposure of Epithelial Cells to Carbon Black (Nano)Particles in the Presence of S. aureus: A Role for Stressed Cells in Toxicological Testing. Biomedicines, 12(1), 128
https://doi.org/10.3390/biomedicines12010128, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65427
Evans, S., Lawrence, R., Ilett, M., Burgum, M., Meldrum, K., Hondow, N., Jenkins, G., Clift, M., & Doak, S. (2022). Industrial-relevant TiO2 types do not promote cytotoxicity in the A549 or TK6 cell lines regardless of cell specific interaction. Toxicology in Vitro, 83, 105415
https://doi.org/10.1016/j.tiv.2022.105415, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60312
Llewellyn, S., Parak, W., Hühn, J., Burgum, M., Evans, S., Chapman, K., Jenkins, G., Doak, S., & Clift, M. (2022). Deducing the cellular mechanisms associated with the potential genotoxic impact of gold and silver engineered nanoparticles upon different lung epithelial cell lines in vitro. Nanotoxicology, 16(1), 52-72.
https://doi.org/10.1080/17435390.2022.2030823, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59210
Burgum, M., Clift, M., Evans, S., Hondow, N., Miller, M., Bustamante-Lopez, S., Williams, A., Tarat, A., Jenkins, G., & Doak, S. (2021). In Vitro Primary‐Indirect Genotoxicity in Bronchial Epithelial Cells Promoted by Industrially Relevant Few‐Layer Graphene. Small, 17(15), 2002551
https://doi.org/10.1002/smll.202002551, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54412
Burgum, M., Clift, M., Evans, S., Hondow, N., Tarat, A., Jenkins, G., & Doak, S. (2021). Few-layer graphene induces both primary and secondary genotoxicity in epithelial barrier models in vitro. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00769-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56078
Evans, S., Clift, M., Singh, N., Wills, J., Hondow, N., Wilkinson, T., Burgum, M., Brown, A., Jenkins, G., & Doak, S. (2019). In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials. Particle and Fibre Toxicology, 16(1)
https://doi.org/10.1186/s12989-019-0291-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48861

Modiwlau a Addysgir

PM-351 Nanotoxicology

Nanomaterials are comprised of very small particles that provide many of the products we use increased strength, chemical reactivity or conductivity. They can also be the by-product of e.g. industrial processes or they can occur naturally, as with soot from forest fires or volcanic ash. The particles range in size from approximately 1 to 100 nanometres; that is 1 / 1,000,000,000th of a metre. Due to their small size they can readily enter our bodies through a number of exposure routes, of which inhalation, ingestion or absorption through the skin, as well as injection into the circulation are dominant. These particles have unique properties compared to their larger counterparts and we are only beginning to understand what their health effects may be. The purpose of this module is to give an introduction into the field of nanoscience, nanotechnology and the potential risks posed by this new Industrial Age to humans.
PM-M28 Nano(geno)toxicology

The field of nanotechnology is ever increasing in size, and the number of nano-sized (1-100nm) particles being produced on a daily basis is at the tonnage level. Although nanotechnology-based applications are considered to be advantageous for a plethora of human activities, the potential risks posed by human exposure to nanoparticles is a constantly developing field of research. The purpose of this module therefore is to introduce to the student to particle toxicology and how it can impact upon human health. Further to this, the students will undertake a specific practical component to complement that of the theoretical content of the module. To this extent, the students will undertake a week-long, 'mini-project', covering the major areas of nanoparticle toxicology. From this approach, it is intended that the student will experience the key practical approaches taken in the field.

Dr Michael Burgum

Rhif ffôn

Cyfeiriad ebost

Welsh language proficiency

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